Diagnostic performance of the “MESACUP anti-Skin profile TEST”
Background The “MESACUP anti-Skin profile TEST” is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays. Objectives The aim of this studywas...
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| Veröffentlicht in: | EJD. European journal of dermatology 2016, Vol.26 (1), p.56-63 |
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| container_title | EJD. European journal of dermatology |
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| creator | Horváth, Orsolya N. Varga, Rita Kaneda, Makoto Schmidt, Enno Ruzicka, Thomas Sárdy, Miklós |
| description | Background
The “MESACUP anti-Skin profile TEST” is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays.
Objectives
The aim of this studywas to evaluate the diagnostic accuracy of this kit for the diagnosis of pemphigus foliaceus, pemphigus vulgaris, bullous pemphigoid and epidermolysis bullosa acquisita.
Materials & Methods
Dual-centre retrospective study in which 138 patients with autoimmune blistering diseases were compared to 40 controls
Results
Using the MESACUP anti-Skin profile TEST, both sensitivities and specificities for desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen autoantibodies were similar to those obtained using previous, specific ELISA systems and 88% of the results were concordant without any significant difference.
Conclusion
The MESACUP anti-Skin profile TEST had a similar performance to previously produced ELISA systems. The novel kit can be used for rapid diagnosis of most common autoimmune blistering diseases and is especially suitable for identifying overlapping disorders. |
| doi_str_mv | 10.1684/ejd.2015.2692 |
| format | Article |
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The “MESACUP anti-Skin profile TEST” is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays.
Objectives
The aim of this studywas to evaluate the diagnostic accuracy of this kit for the diagnosis of pemphigus foliaceus, pemphigus vulgaris, bullous pemphigoid and epidermolysis bullosa acquisita.
Materials & Methods
Dual-centre retrospective study in which 138 patients with autoimmune blistering diseases were compared to 40 controls
Results
Using the MESACUP anti-Skin profile TEST, both sensitivities and specificities for desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen autoantibodies were similar to those obtained using previous, specific ELISA systems and 88% of the results were concordant without any significant difference.
Conclusion
The MESACUP anti-Skin profile TEST had a similar performance to previously produced ELISA systems. The novel kit can be used for rapid diagnosis of most common autoimmune blistering diseases and is especially suitable for identifying overlapping disorders.</description><identifier>ISSN: 1167-1122</identifier><identifier>EISSN: 1952-4013</identifier><identifier>DOI: 10.1684/ejd.2015.2692</identifier><identifier>PMID: 26771500</identifier><language>eng</language><publisher>Paris: John Libbey Eurotext</publisher><subject>Autoantibodies - blood ; Autoantigens - immunology ; Collagen Type VII - immunology ; Collagen Type XVII ; Dermatology ; Desmoglein 1 - immunology ; Desmoglein 3 - immunology ; Dystonin - immunology ; Enzyme-Linked Immunosorbent Assay - methods ; Humans ; Immunoglobulin G - blood ; Investigative Report ; Medicine ; Medicine & Public Health ; Non-Fibrillar Collagens - immunology ; Retrospective Studies ; Sensitivity and Specificity ; Skin - immunology ; Skin Diseases, Vesiculobullous - diagnosis ; Skin Diseases, Vesiculobullous - immunology</subject><ispartof>EJD. European journal of dermatology, 2016, Vol.26 (1), p.56-63</ispartof><rights>John Libbey Eurotext 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-9ee8a030aef571dcdfcccd680c0cd1d7ad977aed9e4a8f6eeaf9fdca677b77a33</citedby><cites>FETCH-LOGICAL-c371t-9ee8a030aef571dcdfcccd680c0cd1d7ad977aed9e4a8f6eeaf9fdca677b77a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1684/ejd.2015.2692$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1684/ejd.2015.2692$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26771500$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horváth, Orsolya N.</creatorcontrib><creatorcontrib>Varga, Rita</creatorcontrib><creatorcontrib>Kaneda, Makoto</creatorcontrib><creatorcontrib>Schmidt, Enno</creatorcontrib><creatorcontrib>Ruzicka, Thomas</creatorcontrib><creatorcontrib>Sárdy, Miklós</creatorcontrib><title>Diagnostic performance of the “MESACUP anti-Skin profile TEST”</title><title>EJD. European journal of dermatology</title><addtitle>Eur J Dermatol</addtitle><addtitle>Eur J Dermatol</addtitle><description>Background
The “MESACUP anti-Skin profile TEST” is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays.
Objectives
The aim of this studywas to evaluate the diagnostic accuracy of this kit for the diagnosis of pemphigus foliaceus, pemphigus vulgaris, bullous pemphigoid and epidermolysis bullosa acquisita.
Materials & Methods
Dual-centre retrospective study in which 138 patients with autoimmune blistering diseases were compared to 40 controls
Results
Using the MESACUP anti-Skin profile TEST, both sensitivities and specificities for desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen autoantibodies were similar to those obtained using previous, specific ELISA systems and 88% of the results were concordant without any significant difference.
Conclusion
The MESACUP anti-Skin profile TEST had a similar performance to previously produced ELISA systems. The novel kit can be used for rapid diagnosis of most common autoimmune blistering diseases and is especially suitable for identifying overlapping disorders.</description><subject>Autoantibodies - blood</subject><subject>Autoantigens - immunology</subject><subject>Collagen Type VII - immunology</subject><subject>Collagen Type XVII</subject><subject>Dermatology</subject><subject>Desmoglein 1 - immunology</subject><subject>Desmoglein 3 - immunology</subject><subject>Dystonin - immunology</subject><subject>Enzyme-Linked Immunosorbent Assay - methods</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Investigative Report</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Non-Fibrillar Collagens - immunology</subject><subject>Retrospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Skin - immunology</subject><subject>Skin Diseases, Vesiculobullous - diagnosis</subject><subject>Skin Diseases, Vesiculobullous - immunology</subject><issn>1167-1122</issn><issn>1952-4013</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kLtOAzEQRS0EIiFQ0qItaXaxvQ-vyxDCQwoCKUltOfY4bNhHsHcLunwI_Fy-BEcJdFQz0hzdmTkIXRIckSxPbmClI4pJGtGM0yPUJzylYYJJfOx7krGQEEp76My5FcYU8zg_RT2aMUZSjPvo9q6Qy7pxbaGCNVjT2ErWCoLGBO0bBNvN1_N4OhzNXwNZt0U4fS_qYG0bU5QQzMbT2XbzfY5OjCwdXBzqAM3vx7PRYzh5eXgaDSehihlpQw6QSxxjCSZlRCttlFI6y7HCShPNpOaMSdAcEpmbDEAabrSS_tSFH8TxAF3vc_3-jw5cK6rCKShLWUPTOUEYYwnHnBOPhntU2cY5C0asbVFJ-ykIFjttwmsTO21ip83zV4foblGB_qN_PXkg2gPOj-olWLFqOlv7d_9J_AG-AXm9</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Horváth, Orsolya N.</creator><creator>Varga, Rita</creator><creator>Kaneda, Makoto</creator><creator>Schmidt, Enno</creator><creator>Ruzicka, Thomas</creator><creator>Sárdy, Miklós</creator><general>John Libbey Eurotext</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Diagnostic performance of the “MESACUP anti-Skin profile TEST”</title><author>Horváth, Orsolya N. ; Varga, Rita ; Kaneda, Makoto ; Schmidt, Enno ; Ruzicka, Thomas ; Sárdy, Miklós</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-9ee8a030aef571dcdfcccd680c0cd1d7ad977aed9e4a8f6eeaf9fdca677b77a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Autoantibodies - blood</topic><topic>Autoantigens - immunology</topic><topic>Collagen Type VII - immunology</topic><topic>Collagen Type XVII</topic><topic>Dermatology</topic><topic>Desmoglein 1 - immunology</topic><topic>Desmoglein 3 - immunology</topic><topic>Dystonin - immunology</topic><topic>Enzyme-Linked Immunosorbent Assay - methods</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Investigative Report</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Non-Fibrillar Collagens - immunology</topic><topic>Retrospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Skin - immunology</topic><topic>Skin Diseases, Vesiculobullous - diagnosis</topic><topic>Skin Diseases, Vesiculobullous - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Horváth, Orsolya N.</creatorcontrib><creatorcontrib>Varga, Rita</creatorcontrib><creatorcontrib>Kaneda, Makoto</creatorcontrib><creatorcontrib>Schmidt, Enno</creatorcontrib><creatorcontrib>Ruzicka, Thomas</creatorcontrib><creatorcontrib>Sárdy, Miklós</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>EJD. European journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Horváth, Orsolya N.</au><au>Varga, Rita</au><au>Kaneda, Makoto</au><au>Schmidt, Enno</au><au>Ruzicka, Thomas</au><au>Sárdy, Miklós</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic performance of the “MESACUP anti-Skin profile TEST”</atitle><jtitle>EJD. European journal of dermatology</jtitle><stitle>Eur J Dermatol</stitle><addtitle>Eur J Dermatol</addtitle><date>2016</date><risdate>2016</risdate><volume>26</volume><issue>1</issue><spage>56</spage><epage>63</epage><pages>56-63</pages><issn>1167-1122</issn><eissn>1952-4013</eissn><abstract>Background
The “MESACUP anti-Skin profile TEST” is a new, commercially available ELISA kit to detect circulating IgG autoantibodies against desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen, both simultaneously and more rapidly than previous assays.
Objectives
The aim of this studywas to evaluate the diagnostic accuracy of this kit for the diagnosis of pemphigus foliaceus, pemphigus vulgaris, bullous pemphigoid and epidermolysis bullosa acquisita.
Materials & Methods
Dual-centre retrospective study in which 138 patients with autoimmune blistering diseases were compared to 40 controls
Results
Using the MESACUP anti-Skin profile TEST, both sensitivities and specificities for desmoglein 1, desmoglein 3, BP180, BP230, and type VII collagen autoantibodies were similar to those obtained using previous, specific ELISA systems and 88% of the results were concordant without any significant difference.
Conclusion
The MESACUP anti-Skin profile TEST had a similar performance to previously produced ELISA systems. The novel kit can be used for rapid diagnosis of most common autoimmune blistering diseases and is especially suitable for identifying overlapping disorders.</abstract><cop>Paris</cop><pub>John Libbey Eurotext</pub><pmid>26771500</pmid><doi>10.1684/ejd.2015.2692</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Autoantibodies - blood Autoantigens - immunology Collagen Type VII - immunology Collagen Type XVII Dermatology Desmoglein 1 - immunology Desmoglein 3 - immunology Dystonin - immunology Enzyme-Linked Immunosorbent Assay - methods Humans Immunoglobulin G - blood Investigative Report Medicine Medicine & Public Health Non-Fibrillar Collagens - immunology Retrospective Studies Sensitivity and Specificity Skin - immunology Skin Diseases, Vesiculobullous - diagnosis Skin Diseases, Vesiculobullous - immunology |
| title | Diagnostic performance of the “MESACUP anti-Skin profile TEST” |
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