Neoglycoenzyme-Gated Mesoporous Silica Nanoparticles: Toward the Design of Nanodevices for Pulsatile Programmed Sequential Delivery

We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous silica nanoparticles. The dual-release mechanism was based on the distinct st...

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Veröffentlicht in:	ACS applied materials & interfaces 2016-03, Vol.8 (12), p.7657-7665
Hauptverfasser:	Díez, Paula, Sánchez, Alfredo, Torre, Cristina de la, Gamella, María, Martínez-Ruíz, Paloma, Aznar, Elena, Martínez-Máñez, Ramón, Pingarrón, José M, Villalonga, Reynaldo
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Sprache:	eng
Schlagworte:	Drug Delivery Systems - methods HeLa Cells Humans Nanoparticles - chemistry Porosity Silicon Dioxide
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creator	Díez, Paula Sánchez, Alfredo Torre, Cristina de la Gamella, María Martínez-Ruíz, Paloma Aznar, Elena Martínez-Máñez, Ramón Pingarrón, José M Villalonga, Reynaldo
description	We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous silica nanoparticles. The dual-release mechanism was based on the distinct stability of the cyclic boronic acid esters formed with lactose residues and the long naturally occurring glycosylation chains in the modified neoglycoenzyme. Cargo delivery in succession was achieved using glucose and ethyl butyrate as triggers.
doi_str_mv	10.1021/acsami.5b12645
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subjects	Drug Delivery Systems - methods HeLa Cells Humans Nanoparticles - chemistry Porosity Silicon Dioxide
title	Neoglycoenzyme-Gated Mesoporous Silica Nanoparticles: Toward the Design of Nanodevices for Pulsatile Programmed Sequential Delivery
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