Methoxychlor Induces Proliferation of the Mouse Ovarian Surface Epithelium

While the pesticide methoxychlor (MXC) has a variety of adverse effects on the female reproductive system, the effects of MXC on the ovarian surface epithelium (OSE) are unknown. Thus, this study tested the hypothesis that MXC alters the growth of the OSE. Mouse OSE cells were isolated by enzymatic...

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Veröffentlicht in:	Toxicological sciences 2005-02, Vol.83 (2), p.355-362
Hauptverfasser:	Symonds, Daniel A., Tomic, Dragana, Miller, Kimberly P., Flaws, Jodi A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals apoptosis Apoptosis - drug effects bcl-2-Associated X Protein Cell Count Cell Culture Techniques - methods cell cycle Cell Proliferation - drug effects Cells, Cultured Cyclin D2 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - genetics Cyclin-Dependent Kinases - metabolism Cyclins - genetics Cyclins - metabolism Epithelium - drug effects Epithelium - metabolism Epithelium - pathology Estradiol - analogs & derivatives Estradiol - pharmacology Estrogen Antagonists - pharmacology estrogen receptor Estrogen Receptor alpha - drug effects Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Female Insecticides - toxicity methoxychlor Methoxychlor - toxicity Mice Mice, Inbred Strains ovarian surface epithelium Ovary - drug effects Ovary - metabolism Ovary - pathology Phenols - toxicity proliferation Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism
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