IFN-alpha beta secreted during infection is necessary but not sufficient for negative feedback regulation of IFN-alpha beta signaling by Mycobacterium tuberculosis

IFN-alphabeta functions in the transition from innate to adaptive immunity and may impinge on the interaction of Mycobacterium tuberculosis with its host. Infection by M. tuberculosis causes IFN-alphabeta secretion and down-regulation of IFN-alphabeta signaling in human APC and the human monocytic c...

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Veröffentlicht in:	The Journal of immunology (1950) 2005-01, Vol.174 (2), p.1003-1012
Hauptverfasser:	Prabhakar, Savita, Qiao, Yaming, Canova, Antony, Tse, Doris B, Pine, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Membrane - immunology Cell Membrane - metabolism Cell Membrane - microbiology Culture Media, Conditioned - pharmacology Cytoplasm - immunology Cytoplasm - metabolism Cytoplasm - microbiology Down-Regulation - immunology Feedback Humans Interferon-alpha - antagonists & inhibitors Interferon-alpha - metabolism Interferon-alpha - physiology Interferon-beta - metabolism Interferon-beta - physiology Intracellular Signaling Peptides and Proteins Janus Kinase 1 Lipopolysaccharides - pharmacology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases - metabolism Protein-Tyrosine Kinases - antagonists & inhibitors Protein-Tyrosine Kinases - metabolism Receptor, Interferon alpha-beta Receptors, Interferon - metabolism Signal Transduction - immunology TYK2 Kinase Tyrosine - antagonists & inhibitors Tyrosine - metabolism
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