Plasma cells in primary melanoma. Prognostic significance and possible role of IgA

Melanoma is not only one of the most immunogenic cancers but also one of the most effective cancers at subverting host immunity. The role of T lymphocytes in tumor immunity has been extensively studied in melanoma, whereas less is known about the importance of B lymphocytes. The effects of plasma ce...

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Veröffentlicht in:Modern pathology 2016-04, Vol.29 (4), p.347-358
Hauptverfasser: Bosisio, Francesca M, Wilmott, James S, Volders, Nathalie, Mercier, Marjorie, Wouters, Jasper, Stas, Marguerite, Blokx, Willeke AM, Massi, Daniela, Thompson, John F, Scolyer, Richard A, van Baren, Nicolas, van den Oord, Joost J
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container_issue 4
container_start_page 347
container_title Modern pathology
container_volume 29
creator Bosisio, Francesca M
Wilmott, James S
Volders, Nathalie
Mercier, Marjorie
Wouters, Jasper
Stas, Marguerite
Blokx, Willeke AM
Massi, Daniela
Thompson, John F
Scolyer, Richard A
van Baren, Nicolas
van den Oord, Joost J
description Melanoma is not only one of the most immunogenic cancers but also one of the most effective cancers at subverting host immunity. The role of T lymphocytes in tumor immunity has been extensively studied in melanoma, whereas less is known about the importance of B lymphocytes. The effects of plasma cells (PCs), in particular, are still obscure. The aim of this study was to characterize pathological features and clinical outcome of primary cutaneous melanomas associated with PCs. Moreover, we investigated the origins of the melanoma-associated PCs. Finally, we studied the outcome of patients with primary melanomas with PCs. We reviewed 710 melanomas to correlate the presence of PCs with histological prognostic markers. Immunohistochemistry for CD138 and heavy and light chains was performed in primary melanomas (PM) and in loco-regional lymph nodes (LN), both metastatic and not metastatic. In three PM and nine LN with frozen material, VDJ-rearrangement was analyzed by Gene Scan Analysis. Survival analysis was performed on a group of 85 primary melanomas >2 mm in thickness. Forty-one cases (3.7%) showed clusters/sheets of PCs. PC-rich melanomas occurred at an older age and were thicker, more often ulcerated and more mitotically active ( P
doi_str_mv 10.1038/modpathol.2016.28
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subjects 13/51
14/63
38/90
38/91
692/53/2422
82/51
Adolescent
Adult
Aged
Aged, 80 and over
Cancer
Child
Female
Humans
Immunoglobulin A
Immunohistochemistry
Kaplan-Meier Estimate
Laboratory Medicine
Lymphatic system
Lymphocytes
Lymphocytes, Tumor-Infiltrating - immunology
Male
Medical prognosis
Medical research
Medicine
Medicine & Public Health
Melanoma
Melanoma - immunology
Melanoma - mortality
Melanoma - pathology
Metastasis
Middle Aged
Oncology
original-article
Pathology
Plasma
Plasma Cells - immunology
Prognosis
Reverse Transcriptase Polymerase Chain Reaction
Skin Neoplasms - immunology
Skin Neoplasms - mortality
Skin Neoplasms - pathology
Survival analysis
Young Adult
title Plasma cells in primary melanoma. Prognostic significance and possible role of IgA
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