Impaired physical function following pediatric LT

The purpose of this article is to investigate the spectrum of physical function of pediatric liver transplantation (LT) recipients 12‐24 months after LT. Review data were collected through the functional outcomes group, an ancillary study of the Studies of Pediatric Liver Transplantation registry. P...

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Veröffentlicht in:Liver transplantation 2016-04, Vol.22 (4), p.495-504
Hauptverfasser: Feldman, Amy G., Neighbors, Katie, Mukherjee, Shubhra, Rak, Melanie, Varni, James W., Alonso, Estella M.
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container_end_page 504
container_issue 4
container_start_page 495
container_title Liver transplantation
container_volume 22
creator Feldman, Amy G.
Neighbors, Katie
Mukherjee, Shubhra
Rak, Melanie
Varni, James W.
Alonso, Estella M.
description The purpose of this article is to investigate the spectrum of physical function of pediatric liver transplantation (LT) recipients 12‐24 months after LT. Review data were collected through the functional outcomes group, an ancillary study of the Studies of Pediatric Liver Transplantation registry. Patients were eligible if they had survived LT by 12‐24 months. Children ≥ 8 years and parents completed the Pediatric Quality of Life Inventory™ 4.0 generic core scales, which includes 8 questions assessing physical function. Scores were compared to a matched healthy child population (n = 1658) and between survivors with optimal versus nonoptimal health. A total of 263 patients were included. Median age at transplant and survey was 4.8 years (interquartile range [IQR], 1.3‐11.4 years) and 5.9 years (IQR, 2.6‐13.1 years), respectively. The mean physical functioning score on child and parent reports were 81.2 ± 17.3 and 77.1 ± 23.7, respectively. Compared to a matched healthy population, transplant survivors and their parents reported lower physical function scores (P 
doi_str_mv 10.1002/lt.24406
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Review data were collected through the functional outcomes group, an ancillary study of the Studies of Pediatric Liver Transplantation registry. Patients were eligible if they had survived LT by 12‐24 months. Children ≥ 8 years and parents completed the Pediatric Quality of Life Inventory™ 4.0 generic core scales, which includes 8 questions assessing physical function. Scores were compared to a matched healthy child population (n = 1658) and between survivors with optimal versus nonoptimal health. A total of 263 patients were included. Median age at transplant and survey was 4.8 years (interquartile range [IQR], 1.3‐11.4 years) and 5.9 years (IQR, 2.6‐13.1 years), respectively. The mean physical functioning score on child and parent reports were 81.2 ± 17.3 and 77.1 ± 23.7, respectively. Compared to a matched healthy population, transplant survivors and their parents reported lower physical function scores (P &lt; 0.001); 32.9% of patients and 35.0% of parents reported a physical function score &lt;75, which is &gt; 1 standard deviation below the mean of a healthy population. Physical functioning scores were significantly higher in survivors with optimal health than those with nonoptimal health (P &lt; 0.01). There was a significant relationship between emotional functioning and physical functioning scores for LT recipients (r = 0.69; P &lt; 0.001). In multivariate analysis, primary disease, height z score &lt; –1.64 at longterm follow‐up (LTF) visit,  &gt; 4 days of hospitalization since LTF visit, and not being listed as status 1 were predictors of poor physical function. In conclusion, pediatric LT recipients 1‐2 years after LT and their parents report lower physical function than a healthy population. Findings suggest practitioners need to routinely assess physical function, and the development of rehabilitation programs may be important. Liver Transplantation 22 495‐504 2016 AASLD</description><identifier>ISSN: 1527-6465</identifier><identifier>EISSN: 1527-6473</identifier><identifier>DOI: 10.1002/lt.24406</identifier><identifier>PMID: 26850789</identifier><identifier>CODEN: LITRFO</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Child ; Child, Preschool ; Female ; Follow-Up Studies ; Health Status ; Hospitalization ; Humans ; Infant ; Liver cirrhosis ; Liver Diseases - surgery ; Liver Transplantation - adverse effects ; Liver Transplantation - mortality ; Male ; Multivariate Analysis ; Pediatrics ; Population ; Quality of Life ; Registries - statistics &amp; numerical data ; Surveys and Questionnaires ; Survivors - psychology ; Transplants &amp; implants ; Treatment Outcome</subject><ispartof>Liver transplantation, 2016-04, Vol.22 (4), p.495-504</ispartof><rights>2016 American Association for the Study of Liver Diseases</rights><rights>2016 American Association for the Study of Liver Diseases.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3836-70210494fd8283f843ca5aa8fae14c63d2d30b0a6b0b1dd7861796ec98b173a53</citedby><cites>FETCH-LOGICAL-c3836-70210494fd8283f843ca5aa8fae14c63d2d30b0a6b0b1dd7861796ec98b173a53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flt.24406$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flt.24406$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26850789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feldman, Amy G.</creatorcontrib><creatorcontrib>Neighbors, Katie</creatorcontrib><creatorcontrib>Mukherjee, Shubhra</creatorcontrib><creatorcontrib>Rak, Melanie</creatorcontrib><creatorcontrib>Varni, James W.</creatorcontrib><creatorcontrib>Alonso, Estella M.</creatorcontrib><title>Impaired physical function following pediatric LT</title><title>Liver transplantation</title><addtitle>Liver Transpl</addtitle><description>The purpose of this article is to investigate the spectrum of physical function of pediatric liver transplantation (LT) recipients 12‐24 months after LT. Review data were collected through the functional outcomes group, an ancillary study of the Studies of Pediatric Liver Transplantation registry. Patients were eligible if they had survived LT by 12‐24 months. Children ≥ 8 years and parents completed the Pediatric Quality of Life Inventory™ 4.0 generic core scales, which includes 8 questions assessing physical function. Scores were compared to a matched healthy child population (n = 1658) and between survivors with optimal versus nonoptimal health. A total of 263 patients were included. Median age at transplant and survey was 4.8 years (interquartile range [IQR], 1.3‐11.4 years) and 5.9 years (IQR, 2.6‐13.1 years), respectively. The mean physical functioning score on child and parent reports were 81.2 ± 17.3 and 77.1 ± 23.7, respectively. Compared to a matched healthy population, transplant survivors and their parents reported lower physical function scores (P &lt; 0.001); 32.9% of patients and 35.0% of parents reported a physical function score &lt;75, which is &gt; 1 standard deviation below the mean of a healthy population. Physical functioning scores were significantly higher in survivors with optimal health than those with nonoptimal health (P &lt; 0.01). There was a significant relationship between emotional functioning and physical functioning scores for LT recipients (r = 0.69; P &lt; 0.001). In multivariate analysis, primary disease, height z score &lt; –1.64 at longterm follow‐up (LTF) visit,  &gt; 4 days of hospitalization since LTF visit, and not being listed as status 1 were predictors of poor physical function. In conclusion, pediatric LT recipients 1‐2 years after LT and their parents report lower physical function than a healthy population. Findings suggest practitioners need to routinely assess physical function, and the development of rehabilitation programs may be important. Liver Transplantation 22 495‐504 2016 AASLD</description><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Health Status</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Infant</subject><subject>Liver cirrhosis</subject><subject>Liver Diseases - surgery</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver Transplantation - mortality</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Pediatrics</subject><subject>Population</subject><subject>Quality of Life</subject><subject>Registries - statistics &amp; numerical data</subject><subject>Surveys and Questionnaires</subject><subject>Survivors - psychology</subject><subject>Transplants &amp; implants</subject><subject>Treatment Outcome</subject><issn>1527-6465</issn><issn>1527-6473</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kF1LwzAUQIMobk7BXyAFX3zpvEnaJH2U4ceg4Mt8Dmmaakb6YdIy9u_t3Jwg-HTvw-Fw70HoGsMcA5B7189JkgA7QVOcEh6zhNPT487SCboIYQ2AcZrBOZoQJlLgIpsivKw7Zb0po-5jG6xWLqqGRve2baKqda7d2OY96kxpVe-tjvLVJTqrlAvm6jBn6O3pcbV4ifPX5-XiIY81FZTFHAiGJEuqUhBBK5FQrVKlRKUMTjSjJSkpFKBYAQUuSy4Y5hkzOhMF5lSldIbu9t7Ot5-DCb2sbdDGOdWYdggSc853P2R4RG__oOt28M143Y5iGFIC2a9Q-zYEbyrZeVsrv5UY5C6jdL38zjiiNwfhUNSmPII_3UYg3gMb68z2X5HMV3vhF_NFeKk</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Feldman, Amy G.</creator><creator>Neighbors, Katie</creator><creator>Mukherjee, Shubhra</creator><creator>Rak, Melanie</creator><creator>Varni, James W.</creator><creator>Alonso, Estella M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201604</creationdate><title>Impaired physical function following pediatric LT</title><author>Feldman, Amy G. ; Neighbors, Katie ; Mukherjee, Shubhra ; Rak, Melanie ; Varni, James W. ; Alonso, Estella M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3836-70210494fd8283f843ca5aa8fae14c63d2d30b0a6b0b1dd7861796ec98b173a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Health Status</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Infant</topic><topic>Liver cirrhosis</topic><topic>Liver Diseases - surgery</topic><topic>Liver Transplantation - adverse effects</topic><topic>Liver Transplantation - mortality</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Pediatrics</topic><topic>Population</topic><topic>Quality of Life</topic><topic>Registries - statistics &amp; numerical data</topic><topic>Surveys and Questionnaires</topic><topic>Survivors - psychology</topic><topic>Transplants &amp; implants</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Feldman, Amy G.</creatorcontrib><creatorcontrib>Neighbors, Katie</creatorcontrib><creatorcontrib>Mukherjee, Shubhra</creatorcontrib><creatorcontrib>Rak, Melanie</creatorcontrib><creatorcontrib>Varni, James W.</creatorcontrib><creatorcontrib>Alonso, Estella M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Liver transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feldman, Amy G.</au><au>Neighbors, Katie</au><au>Mukherjee, Shubhra</au><au>Rak, Melanie</au><au>Varni, James W.</au><au>Alonso, Estella M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired physical function following pediatric LT</atitle><jtitle>Liver transplantation</jtitle><addtitle>Liver Transpl</addtitle><date>2016-04</date><risdate>2016</risdate><volume>22</volume><issue>4</issue><spage>495</spage><epage>504</epage><pages>495-504</pages><issn>1527-6465</issn><eissn>1527-6473</eissn><coden>LITRFO</coden><abstract>The purpose of this article is to investigate the spectrum of physical function of pediatric liver transplantation (LT) recipients 12‐24 months after LT. Review data were collected through the functional outcomes group, an ancillary study of the Studies of Pediatric Liver Transplantation registry. Patients were eligible if they had survived LT by 12‐24 months. Children ≥ 8 years and parents completed the Pediatric Quality of Life Inventory™ 4.0 generic core scales, which includes 8 questions assessing physical function. Scores were compared to a matched healthy child population (n = 1658) and between survivors with optimal versus nonoptimal health. A total of 263 patients were included. Median age at transplant and survey was 4.8 years (interquartile range [IQR], 1.3‐11.4 years) and 5.9 years (IQR, 2.6‐13.1 years), respectively. The mean physical functioning score on child and parent reports were 81.2 ± 17.3 and 77.1 ± 23.7, respectively. Compared to a matched healthy population, transplant survivors and their parents reported lower physical function scores (P &lt; 0.001); 32.9% of patients and 35.0% of parents reported a physical function score &lt;75, which is &gt; 1 standard deviation below the mean of a healthy population. Physical functioning scores were significantly higher in survivors with optimal health than those with nonoptimal health (P &lt; 0.01). There was a significant relationship between emotional functioning and physical functioning scores for LT recipients (r = 0.69; P &lt; 0.001). In multivariate analysis, primary disease, height z score &lt; –1.64 at longterm follow‐up (LTF) visit,  &gt; 4 days of hospitalization since LTF visit, and not being listed as status 1 were predictors of poor physical function. In conclusion, pediatric LT recipients 1‐2 years after LT and their parents report lower physical function than a healthy population. Findings suggest practitioners need to routinely assess physical function, and the development of rehabilitation programs may be important. Liver Transplantation 22 495‐504 2016 AASLD</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>26850789</pmid><doi>10.1002/lt.24406</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Adolescent
Child
Child, Preschool
Female
Follow-Up Studies
Health Status
Hospitalization
Humans
Infant
Liver cirrhosis
Liver Diseases - surgery
Liver Transplantation - adverse effects
Liver Transplantation - mortality
Male
Multivariate Analysis
Pediatrics
Population
Quality of Life
Registries - statistics & numerical data
Surveys and Questionnaires
Survivors - psychology
Transplants & implants
Treatment Outcome
title Impaired physical function following pediatric LT
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