Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Japanese Hypertrophic Cardiomyopathy Patients
Background:In addition to the presence of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR), the extent of LGE is considered clinically important in hypertrophic cardiomyopathy (HCM). We evaluated the extent of LGE on CMR in a large series of Japanese HCM patients.Methods ...
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| Veröffentlicht in: | Circulation Journal 2016/03/25, Vol.80(4), pp.950-957 |
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| creator | Hen, Yasuki Iguchi, Nobuo Utanohara, Yuko Takada, Kaori Machida, Haruhiko Takara, Ayako Teraoka, Kunihiko Sumiyoshi, Tetsuya Takamisawa, Itaru Takayama, Morimasa Yoshikawa, Tsutomu |
| description | Background:In addition to the presence of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR), the extent of LGE is considered clinically important in hypertrophic cardiomyopathy (HCM). We evaluated the extent of LGE on CMR in a large series of Japanese HCM patients.Methods and Results:CMR was performed in 317 HCM patients (147 male). The extent of LGE was scored as the sum of LGE-positive segments in a left ventricle (LV) 17-segment model. LGE was present in 246 patients (77.6%). LGE was detected in 3.5±3.1 segments on average. When the patients were divided according to maximum wall thickness (mild, |
| doi_str_mv | 10.1253/circj.CJ-15-1100 |
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We evaluated the extent of LGE on CMR in a large series of Japanese HCM patients.Methods and Results:CMR was performed in 317 HCM patients (147 male). The extent of LGE was scored as the sum of LGE-positive segments in a left ventricle (LV) 17-segment model. LGE was present in 246 patients (77.6%). LGE was detected in 3.5±3.1 segments on average. When the patients were divided according to maximum wall thickness (mild, <20 mm; moderate, 20–29 mm; severe, ≥30 mm), median LGE score increased as wall thickness increased (mild, 2 vs. moderate, 4 vs. severe, 5; P=0.000). When the patients were divided according to ejection fraction (EF) (reduced, <50%; low-normal, 50–65%; normal, >65%), median LGE score increased as EF decreased (reduced, 7 vs. low-normal, 4 vs. normal, 2; P=0.000). On multivariate analysis, reduced EF (OR, 0.947, P=0.015), pressure gradient <30 mmHg (OR, 0.359, P=0.000) and increased maximum wall thickness (OR, 1.236, P=0.000) were independent factors associated with extensive LGE.Conclusions:Progression of LGE was related to increased wall thickness, decreased contractility, and reduced intraventricular pressure gradient. (Circ J 2016; 80: 950–957)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.CJ-15-1100</identifier><identifier>PMID: 26902449</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Asian Continental Ancestry Group ; Cardiac magnetic resonance ; Cardiomyopathy, Hypertrophic - diagnostic imaging ; Contrast Media - administration & dosage ; Ejection fraction ; Female ; Gadolinium - administration & dosage ; Humans ; Hypertrophic cardiomyopathy ; Japan ; Late gadolinium enhancement ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; Retrospective Studies</subject><ispartof>Circulation Journal, 2016/03/25, Vol.80(4), pp.950-957</ispartof><rights>2016 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c622t-dcb69bbedb4ce68ffd4fb7ef16a9fc55653aefd4a5438db2c74aca87f9a446073</citedby><cites>FETCH-LOGICAL-c622t-dcb69bbedb4ce68ffd4fb7ef16a9fc55653aefd4a5438db2c74aca87f9a446073</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26902449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hen, Yasuki</creatorcontrib><creatorcontrib>Iguchi, Nobuo</creatorcontrib><creatorcontrib>Utanohara, Yuko</creatorcontrib><creatorcontrib>Takada, Kaori</creatorcontrib><creatorcontrib>Machida, Haruhiko</creatorcontrib><creatorcontrib>Takara, Ayako</creatorcontrib><creatorcontrib>Teraoka, Kunihiko</creatorcontrib><creatorcontrib>Sumiyoshi, Tetsuya</creatorcontrib><creatorcontrib>Takamisawa, Itaru</creatorcontrib><creatorcontrib>Takayama, Morimasa</creatorcontrib><creatorcontrib>Yoshikawa, Tsutomu</creatorcontrib><title>Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Japanese Hypertrophic Cardiomyopathy Patients</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background:In addition to the presence of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR), the extent of LGE is considered clinically important in hypertrophic cardiomyopathy (HCM). We evaluated the extent of LGE on CMR in a large series of Japanese HCM patients.Methods and Results:CMR was performed in 317 HCM patients (147 male). The extent of LGE was scored as the sum of LGE-positive segments in a left ventricle (LV) 17-segment model. LGE was present in 246 patients (77.6%). LGE was detected in 3.5±3.1 segments on average. When the patients were divided according to maximum wall thickness (mild, <20 mm; moderate, 20–29 mm; severe, ≥30 mm), median LGE score increased as wall thickness increased (mild, 2 vs. moderate, 4 vs. severe, 5; P=0.000). When the patients were divided according to ejection fraction (EF) (reduced, <50%; low-normal, 50–65%; normal, >65%), median LGE score increased as EF decreased (reduced, 7 vs. low-normal, 4 vs. normal, 2; P=0.000). On multivariate analysis, reduced EF (OR, 0.947, P=0.015), pressure gradient <30 mmHg (OR, 0.359, P=0.000) and increased maximum wall thickness (OR, 1.236, P=0.000) were independent factors associated with extensive LGE.Conclusions:Progression of LGE was related to increased wall thickness, decreased contractility, and reduced intraventricular pressure gradient. (Circ J 2016; 80: 950–957)</description><subject>Aged</subject><subject>Asian Continental Ancestry Group</subject><subject>Cardiac magnetic resonance</subject><subject>Cardiomyopathy, Hypertrophic - diagnostic imaging</subject><subject>Contrast Media - administration & dosage</subject><subject>Ejection fraction</subject><subject>Female</subject><subject>Gadolinium - administration & dosage</subject><subject>Humans</subject><subject>Hypertrophic cardiomyopathy</subject><subject>Japan</subject><subject>Late gadolinium enhancement</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtr3DAURk1oSdIk-66Klt04lWxZspfFTB7DlJbSrsW1fDWjwZZcSQMZ6I-v59Fkoyuk831cTpZ9ZPSeFVX5Rdugt_ftMmdVzhilF9k1K7nMeV3Qd8e7yJual1fZhxi3lBYNrZrL7KoQDS04b66zv4uXhC4Rb8gKEpJH6P1gnd2NZOE24DSOx29HWgi9BU2-wdphspr8xOjdgSDPI6ytWxPryBImcBiRPO0nDCn4aTOjx6wf936CtNmTH5Ds3Bpvs_cGhoh353mT_X5Y_Gqf8tX3x-f26yrXoihS3utONF2Hfcc1itqYnptOomECGqOrSlQl4PwIFS_rviu05KChlqYBzgWV5U32-dQ7Bf9nhzGp0UaNwzCv6ndRMSkllbWQdEbpCdXBxxjQqCnYEcJeMaoOztXRuWqXilXq4HyOfDq377oR-9fAf8kz8HACtjHBGl8BCLPGAc-NNVX8cLw1vwEbCApd-Q9w0JrN</recordid><startdate>2016</startdate><enddate>2016</enddate><creator>Hen, Yasuki</creator><creator>Iguchi, Nobuo</creator><creator>Utanohara, Yuko</creator><creator>Takada, Kaori</creator><creator>Machida, Haruhiko</creator><creator>Takara, Ayako</creator><creator>Teraoka, Kunihiko</creator><creator>Sumiyoshi, Tetsuya</creator><creator>Takamisawa, Itaru</creator><creator>Takayama, Morimasa</creator><creator>Yoshikawa, Tsutomu</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2016</creationdate><title>Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Japanese Hypertrophic Cardiomyopathy Patients</title><author>Hen, Yasuki ; Iguchi, Nobuo ; Utanohara, Yuko ; Takada, Kaori ; Machida, Haruhiko ; Takara, Ayako ; Teraoka, Kunihiko ; Sumiyoshi, Tetsuya ; Takamisawa, Itaru ; Takayama, Morimasa ; Yoshikawa, Tsutomu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c622t-dcb69bbedb4ce68ffd4fb7ef16a9fc55653aefd4a5438db2c74aca87f9a446073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged</topic><topic>Asian Continental Ancestry Group</topic><topic>Cardiac magnetic resonance</topic><topic>Cardiomyopathy, Hypertrophic - diagnostic imaging</topic><topic>Contrast Media - administration & dosage</topic><topic>Ejection fraction</topic><topic>Female</topic><topic>Gadolinium - administration & dosage</topic><topic>Humans</topic><topic>Hypertrophic cardiomyopathy</topic><topic>Japan</topic><topic>Late gadolinium enhancement</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hen, Yasuki</creatorcontrib><creatorcontrib>Iguchi, Nobuo</creatorcontrib><creatorcontrib>Utanohara, Yuko</creatorcontrib><creatorcontrib>Takada, Kaori</creatorcontrib><creatorcontrib>Machida, Haruhiko</creatorcontrib><creatorcontrib>Takara, Ayako</creatorcontrib><creatorcontrib>Teraoka, Kunihiko</creatorcontrib><creatorcontrib>Sumiyoshi, Tetsuya</creatorcontrib><creatorcontrib>Takamisawa, Itaru</creatorcontrib><creatorcontrib>Takayama, Morimasa</creatorcontrib><creatorcontrib>Yoshikawa, Tsutomu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hen, Yasuki</au><au>Iguchi, Nobuo</au><au>Utanohara, Yuko</au><au>Takada, Kaori</au><au>Machida, Haruhiko</au><au>Takara, Ayako</au><au>Teraoka, Kunihiko</au><au>Sumiyoshi, Tetsuya</au><au>Takamisawa, Itaru</au><au>Takayama, Morimasa</au><au>Yoshikawa, Tsutomu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Japanese Hypertrophic Cardiomyopathy Patients</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2016</date><risdate>2016</risdate><volume>80</volume><issue>4</issue><spage>950</spage><epage>957</epage><pages>950-957</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background:In addition to the presence of late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR), the extent of LGE is considered clinically important in hypertrophic cardiomyopathy (HCM). We evaluated the extent of LGE on CMR in a large series of Japanese HCM patients.Methods and Results:CMR was performed in 317 HCM patients (147 male). The extent of LGE was scored as the sum of LGE-positive segments in a left ventricle (LV) 17-segment model. LGE was present in 246 patients (77.6%). LGE was detected in 3.5±3.1 segments on average. When the patients were divided according to maximum wall thickness (mild, <20 mm; moderate, 20–29 mm; severe, ≥30 mm), median LGE score increased as wall thickness increased (mild, 2 vs. moderate, 4 vs. severe, 5; P=0.000). When the patients were divided according to ejection fraction (EF) (reduced, <50%; low-normal, 50–65%; normal, >65%), median LGE score increased as EF decreased (reduced, 7 vs. low-normal, 4 vs. normal, 2; P=0.000). On multivariate analysis, reduced EF (OR, 0.947, P=0.015), pressure gradient <30 mmHg (OR, 0.359, P=0.000) and increased maximum wall thickness (OR, 1.236, P=0.000) were independent factors associated with extensive LGE.Conclusions:Progression of LGE was related to increased wall thickness, decreased contractility, and reduced intraventricular pressure gradient. (Circ J 2016; 80: 950–957)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>26902449</pmid><doi>10.1253/circj.CJ-15-1100</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Asian Continental Ancestry Group Cardiac magnetic resonance Cardiomyopathy, Hypertrophic - diagnostic imaging Contrast Media - administration & dosage Ejection fraction Female Gadolinium - administration & dosage Humans Hypertrophic cardiomyopathy Japan Late gadolinium enhancement Magnetic Resonance Imaging - methods Male Middle Aged Retrospective Studies |
| title | Extent of Late Gadolinium Enhancement on Cardiac Magnetic Resonance Imaging in Japanese Hypertrophic Cardiomyopathy Patients |
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