Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history
Background: Recent studies have revealed a possible role for the human papillomavirus (HPV) in the pathogenesis of breast cancer. In this study, patients having both a history of invasive cervical cancer and breast cancer as second primary cancer were selected for enrolment in a study of breast carc...
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| Veröffentlicht in: | Journal of clinical virology 2004-12, Vol.31 (4), p.292-297 |
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| creator | Widschwendter, Andreas Brunhuber, Thomas Wiedemair, Annemarie Mueller-Holzner, Elisabeth Marth, Christian |
| description | Background: Recent studies have revealed a possible role for the human papillomavirus (HPV) in the pathogenesis of breast cancer. In this study, patients having both a history of invasive cervical cancer and breast cancer as second primary cancer were selected for enrolment in a study of breast carcinomas for the presence of HPV.
Methods: Paraffin-embedded tissue from cervical cancer, pelvic lymph nodes, breast cancer and axillary lymph nodes of eleven patients were examined for the presence of HPV DNA using a polymerase chain reaction – enzyme immuno assay. DNA extraction was performed with the “QIAamp Tissue Kit” according to the manufacturer’s instructions. Additionally, serum samples taken between diagnosis of cervical and breast cancer, were analyzed for the presence of HPV DNA to examine a possible haematogenous spread of oncogenic HPV DNA.
Results: All cervical carcinomas were HPV-positive. HPV DNA was detected in seven out of eleven cases in breast cancer and/or axillary lymph node tissue. Six patients had the same HPV type (HPV-16) in cervical cancer and in the corresponding breast cancer/lymph node tissue. In one case, the same HPV DNA type (HPV 16) was detected in cervical cancer, breast cancer and serum sample.
Conclusion: These results suggest that HPV DNA might be transported from the original site of infection to the breast tissue by the bloodstream, and that it is possibly involved in the carcinogenesis of breast neoplasia in some patients. |
| doi_str_mv | 10.1016/j.jcv.2004.06.009 |
| format | Article |
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Methods: Paraffin-embedded tissue from cervical cancer, pelvic lymph nodes, breast cancer and axillary lymph nodes of eleven patients were examined for the presence of HPV DNA using a polymerase chain reaction – enzyme immuno assay. DNA extraction was performed with the “QIAamp Tissue Kit” according to the manufacturer’s instructions. Additionally, serum samples taken between diagnosis of cervical and breast cancer, were analyzed for the presence of HPV DNA to examine a possible haematogenous spread of oncogenic HPV DNA.
Results: All cervical carcinomas were HPV-positive. HPV DNA was detected in seven out of eleven cases in breast cancer and/or axillary lymph node tissue. Six patients had the same HPV type (HPV-16) in cervical cancer and in the corresponding breast cancer/lymph node tissue. In one case, the same HPV DNA type (HPV 16) was detected in cervical cancer, breast cancer and serum sample.
Conclusion: These results suggest that HPV DNA might be transported from the original site of infection to the breast tissue by the bloodstream, and that it is possibly involved in the carcinogenesis of breast neoplasia in some patients.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2004.06.009</identifier><identifier>PMID: 15494272</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Breast cancer ; Breast Neoplasms - complications ; Breast Neoplasms - pathology ; Breast Neoplasms - virology ; Cervical cancer ; Cervical Intraepithelial Neoplasia - complications ; Cervical Intraepithelial Neoplasia - pathology ; Cervical Intraepithelial Neoplasia - virology ; DNA, Viral - analysis ; Female ; Fundamental and applied biological sciences. Psychology ; HPV 16 ; Human papillomavirus ; Human viral diseases ; Humans ; Immunoglobulin G - blood ; Infectious diseases ; Lymph Nodes - virology ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Papillomavirus Infections - complications ; Papillomavirus Infections - virology ; PCR ; Tumors ; Uterine Cervical Neoplasms - complications ; Uterine Cervical Neoplasms - pathology ; Viral diseases ; Virology</subject><ispartof>Journal of clinical virology, 2004-12, Vol.31 (4), p.292-297</ispartof><rights>2004 Elsevier B.V.</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c410t-43774086442340d8e6924ee49b1936a80435e4ba795f9e50f42a66afa80c6ece3</citedby><cites>FETCH-LOGICAL-c410t-43774086442340d8e6924ee49b1936a80435e4ba795f9e50f42a66afa80c6ece3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1386653204001763$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16221558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15494272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Widschwendter, Andreas</creatorcontrib><creatorcontrib>Brunhuber, Thomas</creatorcontrib><creatorcontrib>Wiedemair, Annemarie</creatorcontrib><creatorcontrib>Mueller-Holzner, Elisabeth</creatorcontrib><creatorcontrib>Marth, Christian</creatorcontrib><title>Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history</title><title>Journal of clinical virology</title><addtitle>J Clin Virol</addtitle><description>Background: Recent studies have revealed a possible role for the human papillomavirus (HPV) in the pathogenesis of breast cancer. In this study, patients having both a history of invasive cervical cancer and breast cancer as second primary cancer were selected for enrolment in a study of breast carcinomas for the presence of HPV.
Methods: Paraffin-embedded tissue from cervical cancer, pelvic lymph nodes, breast cancer and axillary lymph nodes of eleven patients were examined for the presence of HPV DNA using a polymerase chain reaction – enzyme immuno assay. DNA extraction was performed with the “QIAamp Tissue Kit” according to the manufacturer’s instructions. Additionally, serum samples taken between diagnosis of cervical and breast cancer, were analyzed for the presence of HPV DNA to examine a possible haematogenous spread of oncogenic HPV DNA.
Results: All cervical carcinomas were HPV-positive. HPV DNA was detected in seven out of eleven cases in breast cancer and/or axillary lymph node tissue. Six patients had the same HPV type (HPV-16) in cervical cancer and in the corresponding breast cancer/lymph node tissue. In one case, the same HPV DNA type (HPV 16) was detected in cervical cancer, breast cancer and serum sample.
Conclusion: These results suggest that HPV DNA might be transported from the original site of infection to the breast tissue by the bloodstream, and that it is possibly involved in the carcinogenesis of breast neoplasia in some patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - complications</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - virology</subject><subject>Cervical cancer</subject><subject>Cervical Intraepithelial Neoplasia - complications</subject><subject>Cervical Intraepithelial Neoplasia - pathology</subject><subject>Cervical Intraepithelial Neoplasia - virology</subject><subject>DNA, Viral - analysis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HPV 16</subject><subject>Human papillomavirus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Infectious diseases</subject><subject>Lymph Nodes - virology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - virology</subject><subject>PCR</subject><subject>Tumors</subject><subject>Uterine Cervical Neoplasms - complications</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Viral diseases</subject><subject>Virology</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtrHDEMgE1JaR7tD-gl-JLeZiq_Z-gp5FkI7aU9G69Xw3qZV23Phvz7etkNueUkIX0S4hMhXxnUDJj-vq23fldzAFmDrgHaD-SMNUZUqtXmpOSi0ZVWgp-S85S2AEwJaT6RU6ZkK7nhZ8TeYkafwzTSqaObZXAjnd0c-n4a3C7EJdHbX9c0jHQV0aVMvRs9xj08uxxwzIk-h7yhpbgL3vWvwCakPMWXz-Rj5_qEX47xgvy9v_tz81g9_X74eXP9VHnJIFdSGCOh0VJyIWHdoG65RJTtirVCuwakUChXzrSqa1FBJ7nT2nWl4zV6FBfk22HvHKd_C6Zsh5A89r0bcVqSZcYY4EoVkB1AH6eUInZ2jmFw8cUysHurdmuLVbu3akHbYrXMXB6XL6sB128TR40FuDoCLhUHXSwOQnrjNOdMqaZwPw4cFhW7gNEmXxx6XIdYvmDXU3jnjP97LJSz</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Widschwendter, Andreas</creator><creator>Brunhuber, Thomas</creator><creator>Wiedemair, Annemarie</creator><creator>Mueller-Holzner, Elisabeth</creator><creator>Marth, Christian</creator><general>Elsevier B.V</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope></search><sort><creationdate>20041201</creationdate><title>Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history</title><author>Widschwendter, Andreas ; Brunhuber, Thomas ; Wiedemair, Annemarie ; Mueller-Holzner, Elisabeth ; Marth, Christian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c410t-43774086442340d8e6924ee49b1936a80435e4ba795f9e50f42a66afa80c6ece3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - complications</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - virology</topic><topic>Cervical cancer</topic><topic>Cervical Intraepithelial Neoplasia - complications</topic><topic>Cervical Intraepithelial Neoplasia - pathology</topic><topic>Cervical Intraepithelial Neoplasia - virology</topic><topic>DNA, Viral - analysis</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HPV 16</topic><topic>Human papillomavirus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Infectious diseases</topic><topic>Lymph Nodes - virology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - virology</topic><topic>PCR</topic><topic>Tumors</topic><topic>Uterine Cervical Neoplasms - complications</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Viral diseases</topic><topic>Virology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Widschwendter, Andreas</creatorcontrib><creatorcontrib>Brunhuber, Thomas</creatorcontrib><creatorcontrib>Wiedemair, Annemarie</creatorcontrib><creatorcontrib>Mueller-Holzner, Elisabeth</creatorcontrib><creatorcontrib>Marth, Christian</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Widschwendter, Andreas</au><au>Brunhuber, Thomas</au><au>Wiedemair, Annemarie</au><au>Mueller-Holzner, Elisabeth</au><au>Marth, Christian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history</atitle><jtitle>Journal of clinical virology</jtitle><addtitle>J Clin Virol</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>31</volume><issue>4</issue><spage>292</spage><epage>297</epage><pages>292-297</pages><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>Background: Recent studies have revealed a possible role for the human papillomavirus (HPV) in the pathogenesis of breast cancer. In this study, patients having both a history of invasive cervical cancer and breast cancer as second primary cancer were selected for enrolment in a study of breast carcinomas for the presence of HPV.
Methods: Paraffin-embedded tissue from cervical cancer, pelvic lymph nodes, breast cancer and axillary lymph nodes of eleven patients were examined for the presence of HPV DNA using a polymerase chain reaction – enzyme immuno assay. DNA extraction was performed with the “QIAamp Tissue Kit” according to the manufacturer’s instructions. Additionally, serum samples taken between diagnosis of cervical and breast cancer, were analyzed for the presence of HPV DNA to examine a possible haematogenous spread of oncogenic HPV DNA.
Results: All cervical carcinomas were HPV-positive. HPV DNA was detected in seven out of eleven cases in breast cancer and/or axillary lymph node tissue. Six patients had the same HPV type (HPV-16) in cervical cancer and in the corresponding breast cancer/lymph node tissue. In one case, the same HPV DNA type (HPV 16) was detected in cervical cancer, breast cancer and serum sample.
Conclusion: These results suggest that HPV DNA might be transported from the original site of infection to the breast tissue by the bloodstream, and that it is possibly involved in the carcinogenesis of breast neoplasia in some patients.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>15494272</pmid><doi>10.1016/j.jcv.2004.06.009</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of clinical virology, 2004-12, Vol.31 (4), p.292-297 |
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| subjects | Adult Aged Biological and medical sciences Breast cancer Breast Neoplasms - complications Breast Neoplasms - pathology Breast Neoplasms - virology Cervical cancer Cervical Intraepithelial Neoplasia - complications Cervical Intraepithelial Neoplasia - pathology Cervical Intraepithelial Neoplasia - virology DNA, Viral - analysis Female Fundamental and applied biological sciences. Psychology HPV 16 Human papillomavirus Human viral diseases Humans Immunoglobulin G - blood Infectious diseases Lymph Nodes - virology Medical sciences Microbiology Middle Aged Miscellaneous Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomavirus Infections - complications Papillomavirus Infections - virology PCR Tumors Uterine Cervical Neoplasms - complications Uterine Cervical Neoplasms - pathology Viral diseases Virology |
| title | Detection of human papillomavirus DNA in breast cancer of patients with cervical cancer history |
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