The Deubiquitinating Enzyme USP1 Regulates the Fanconi Anemia Pathway

Protein ubiquitination and deubiquitination are dynamic processes implicated in the regulation of numerous cellular pathways. Monoubiquitination of the Fanconi anemia (FA) protein FANCD2 appears to be critical in the repair of DNA damage because many of the proteins that are mutated in FA are requir...

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Veröffentlicht in:	Molecular cell 2005-02, Vol.17 (3), p.331-339
Hauptverfasser:	Nijman, Sebastian M.B., Huang, Tony T., Dirac, Annette M.G., Brummelkamp, Thijn R., Kerkhoven, Ron M., D'Andrea, Alan D., Bernards, René
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Animals Arabidopsis Proteins Base Sequence Cell Cycle Cell Line Chromatin - metabolism Chromosome Aberrations DNA Repair Endopeptidases - genetics Endopeptidases - metabolism Fanconi Anemia - enzymology Fanconi Anemia - etiology Fanconi Anemia - genetics Fanconi Anemia Complementation Group D2 Protein Gene Library Humans Mice Mitomycin - toxicity Mutation Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Proteasome Endopeptidase Complex - metabolism RNA Interference RNA, Small Interfering - genetics Ubiquitin - metabolism Ubiquitin-Specific Proteases
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