Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid

Retronecine-based pyrrolizidine alkaloids, such as riddelliine, retrorsine, and monocrotaline, are toxic to domestic livestock and carcinogenic to laboratory rodents. Previous in vitro metabolism studies showed that (±)6,7-dihydro-7-hydroxy-1-(hydroxymethyl)-5 H-pyrrolizine (DHP) and pyrrolizidine a...

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Veröffentlicht in:	Toxicology letters 2005-03, Vol.155 (3), p.411-420
Hauptverfasser:	Wang, Yu-Ping, Yan, Jian, Fu, Peter P., Chou, Ming W.
Format:	Artikel
Sprache:	eng
Schlagworte:	32P-postlabeling Animals Aryl Hydrocarbon Hydroxylases - antagonists & inhibitors Biological and medical sciences Biotransformation Carcinogenesis, carcinogens and anticarcinogens Chemical agents Chromatography, High Pressure Liquid Cytochrome P-450 CYP3A Dehydroretronecine DNA adducts DNA Adducts - analysis DNA Adducts - biosynthesis DNA Adducts - chemistry Female Human liver microsomal metabolism Humans Medical sciences Microsomes, Liver - enzymology Microsomes, Liver - metabolism Monocrotaline Monocrotaline - analogs & derivatives Monocrotaline - chemistry Monocrotaline - metabolism Monocrotaline N-oxide Oxidation-Reduction Oxidoreductases, N-Demethylating - antagonists & inhibitors Pyrrolizidine alkaloid Pyrrolizidine Alkaloids - analysis Pyrrolizidine Alkaloids - metabolism Pyrrolizidine Alkaloids - pharmacology Rats Rats, Inbred F344 Retrorsine Retrorsine N-oxide Riddelliine Riddelliine N-oxide Toxicology Tumors
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