The pharmacokinetics and pharmacodynamics of two HI-6 salts in swine and efficacy in the treatment of GF and soman poisoning

Anesthetized pigs were injected i.m. with 500 mg HI-6 dichloride (HI-6 2Cl) (1-[[[4-(aminocarbonyl)-pyridinio]methoxy]methyl]-2[(hydroxyimino)methyl]pyridinium dichloride; CAS 34433-31-3)) or the molar equivalent of HI-6 dimethanesulphonate (HI-6 DMS) 633 mg. Plasma HI-6 concentrations were measured...

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Veröffentlicht in:	Toxicology (Amsterdam) 2005-03, Vol.208 (3), p.399-409
Hauptverfasser:	Lundy, Paul M., Hill, Ira, Lecavalier, Pierre, Hamilton, Murray G., Vair, Cory, Davidson, Corey, Weatherby, Kendal L., Berger, Bradley J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atropine - pharmacology Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases Chemical Warfare Agents - poisoning Dose-Response Relationship, Drug Gas, fumes Guinea Pigs Male Medical sciences Neuroprotective Agents - pharmacokinetics Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Organophosphate nerve agents Organophosphate Poisoning Organophosphorus Compounds Oximes Oximes (HI-6) Pharmacodynamics Pharmacokinetics Protective ratio Pyridinium Compounds - pharmacokinetics Pyridinium Compounds - pharmacology Pyridinium Compounds - therapeutic use Soman - poisoning Swine Time Factors Toxicology
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