Insulin‐like growth factor 2 mRNA‐binding protein 1 (IGF2BP1) is an important protumorigenic factor in hepatocellular carcinoma

Hepatocarcinogenesis is a stepwise process. It involves several genetic and epigenetic alterations, e.g., loss of tumor suppressor gene expression (TP53, PTEN, RB) as well as activation of oncogenes (c‐MYC, MET, BRAF, RAS). However, the role of RNA‐binding proteins (RBPs), which regulate tumor suppr...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2014-05, Vol.59 (5), p.1900-1911
Hauptverfasser:	Gutschner, Tony, Hämmerle, Monika, Pazaitis, Nikolaos, Bley, Nadine, Fiskin, Evgenij, Uckelmann, Hannah, Heim, Andreas, Groβ, Matthias, Hofmann, Nina, Geffers, Robert, Skawran, Britta, Longerich, Thomas, Breuhahn, Kai, Schirmacher, Peter, Mühleck, Britta, Hüttelmaier, Stefan, Diederichs, Sven
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - pathology Cell Proliferation Gene expression Gene Expression Regulation, Neoplastic Hep G2 Cells Hepatology Humans Insulin-like growth factors Ki-67 Antigen - genetics Liver cancer Liver Neoplasms - etiology Liver Neoplasms - pathology Proteins Proto-Oncogene Proteins c-myc - genetics RNA-Binding Proteins - genetics RNA-Binding Proteins - physiology Rodents
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