MicroRNA‐26a suppresses angiogenesis in human hepatocellular carcinoma by targeting hepatocyte growth factor‐cMet pathway

MicroRNA (miR)‐26a can suppress tumor growth and metastasis of hepatocellular carcinoma (HCC). Since angiogenesis is important for tumor growth and metastasis, we investigated the possible roles of miR‐26a in tumor angiogenesis. Down‐regulation of miR‐26a was found to correlate with an increased ang...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2014-05, Vol.59 (5), p.1874-1885
Hauptverfasser:	Yang, Xin, Zhang, Xiao‐Fei, Lu, Xu, Jia, Hu‐Liang, Liang, Lei, Dong, Qiong‐Zhu, Ye, Qing‐Hai, Qin, Lun‐Xiu
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Movement Cell Proliferation Hepatocyte Growth Factor - genetics Hepatology Humans Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - genetics Liver Neoplasms - pathology Medical prognosis Mice Mice, Inbred BALB C MicroRNAs MicroRNAs - physiology Multivariate analysis Neovascularization, Pathologic - prevention & control Prognosis Proto-Oncogene Proteins c-met - genetics Proto-Oncogene Proteins c-met - metabolism Signal Transduction Vascular Endothelial Growth Factor A - analysis Vascular Endothelial Growth Factor A - antagonists & inhibitors
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