Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions

Pruritus is a seriously disabling symptom accompanying many cholestatic liver disorders. Recent experimental evidence implicated the lysophospholipase, autotaxin (ATX), and its product, lysophosphatidic acid (LPA), as potential mediators of cholestatic pruritus. In this study, we highlight that incr...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2012-10, Vol.56 (4), p.1391-1400
Hauptverfasser:	Kremer, Andreas E., van Dijk, Remco, Leckie, Pamela, Schaap, Frank G., Kuiper, Edith M.M., Mettang, Thomas, Reiners, Katrin S., Raap, Ulrike, van Buuren, Henk R., van Erpecum, Karel J., Davies, Nathan A., Rust, Christian, Engert, Andreas, Jalan, Rajiv, Oude Elferink, Ronald P.J., Beuers, Ulrich
Format:	Artikel
Sprache:	eng
Schlagworte:	Allylamine - analogs & derivatives Allylamine - therapeutic use Analysis of Variance Antipruritics - therapeutic use Bile Biological and medical sciences Biomarkers - blood Blotting, Western Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - complications Case-Control Studies Cholestasis - blood Cholestasis - complications Cohort Studies Colesevelam Hydrochloride Electrophoresis, Polyacrylamide Gel Female Fibroblast Growth Factors - blood Gallbladder diseases Gastroenterology. Liver. Pancreas. Abdomen Hep G2 Cells - metabolism Hepatology Humans Liver Neoplasms - blood Liver Neoplasms - complications Liver. Biliary tract. Portal circulation. Exocrine pancreas Lysophospholipase - blood Male Medical sciences Multivariate Analysis Other diseases. Semiology Phosphoric Diester Hydrolases - blood Phosphoric Diester Hydrolases - metabolism Polymerase Chain Reaction Pruritus - blood Pruritus - drug therapy Pruritus - etiology Rifampin - therapeutic use ROC Curve Treatment Outcome
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