Glucagon‐like peptide 2 counteracts the mucosal damage and the neuropathy induced by chronic treatment with cisplatin in the mouse gastric fundus

Background Glucagon‐like peptide‐2 (GLP‐2) is a pleiotropic hormone synthesized and secreted by the enteroendocrine ‘L’ cells able to exert intestine‐trophic and anti‐inflammatory effects. The antineoplastic drug cisplatin causes gastrointestinal alterations with clinical symptoms (nausea and vomiti...

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Veröffentlicht in:	Neurogastroenterology and motility 2016-02, Vol.28 (2), p.206-216
Hauptverfasser:	Pini, A., Garella, R., Idrizaj, E., Calosi, L., Baccari, M. C., Vannucchi, M. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - toxicity antineoplastic drug Blotting, Western Cisplatin - toxicity Disease Models, Animal Female gastric epithelium Gastric Fundus - drug effects Glucagon-Like Peptide 2 - pharmacology Immunohistochemistry Intestinal Pseudo-Obstruction - chemically induced Mice Mice, Inbred C57BL myenteric plexus Myenteric Plexus - drug effects nitrergic neurons Peptides - pharmacology pleiotropic intestinal hormone Rodents
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