siRNAs targeting PB2 and NP genes potentially inhibit replication of Highly Pathogenic H5N1 Avian Influenza Virus

Highly Pathogenic Avian Influenza (HPAI) H5N1 virus is a threat to animal and public health worldwide. Till date, the H5N1 virus has claimed 402 human lives, with a mortality rate of 58% and has caused the death or culling of millions of poultry since 2003. In this study, we have designed three siRN...

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Veröffentlicht in:	Journal of biosciences 2015-06, Vol.40 (2), p.233-240
Hauptverfasser:	Behera, Padmanava, Nagarajan, Shanmugasundaram, Murugkar, Harshad V, Kalaiyarasu, Semmannan, Prakash, Anil, Gothalwal, Ragini, Dubey, Shiv Chandra, Kulkarni, Diwakar D, Tosh, Chakradhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Avian flu Avian influenza virus Biomedical and Life Sciences Biomedicine Cell Biology Cell Line Chickens - virology Dogs Genetics Humans Influenza A Virus, H5N1 Subtype - genetics Influenza in Birds - drug therapy Influenza in Birds - virology Influenza, Human - drug therapy Influenza, Human - virology Life Sciences Madin Darby Canine Kidney Cells Microbial Sensitivity Tests Microbiology Pathogenesis Plant Sciences Public health Ribonucleic acid RNA RNA Replicase - genetics RNA, Small Interfering - genetics RNA, Small Interfering - therapeutic use RNA-Binding Proteins - genetics Viral Core Proteins - genetics Viral Proteins - genetics Virus Replication - genetics Zoology
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