Protection of Luteolin-7-O-Glucoside Against Doxorubicin-Induced Injury Through PTEN/Akt and ERK Pathway in H9c2 Cells

Luteolin-7- O -glucoside (LUTG) was isolated from the plants of Dracocephalum tanguticum Maxim. Previous research has showed that LUTG pretreatment had a significant protective effect against doxorubicin (DOX)-induced cardiotoxicity by reducing intracellular calcium overload and leakage of creatine...

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Veröffentlicht in:	Cardiovascular toxicology 2016-04, Vol.16 (2), p.101-110
Hauptverfasser:	Yao, Hong, Shang, Zhimei, Wang, Penghong, Li, Shuixian, Zhang, Qianyun, Tian, Huiqin, Ren, Dongmei, Han, Xiuzhen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - toxicity Apoptosis Biomedical and Life Sciences Biomedicine Cardiology Cardiomyocytes Cardiotonic Agents - pharmacology Cardiotoxicity Cell Survival - drug effects Cell Survival - physiology Chromatography Creatine kinase Dehydrogenases Dose-Response Relationship, Drug Doxorubicin - toxicity Dracocephalum Ethylenediaminetetraacetic acid Flavones - pharmacology Glucosides - pharmacology Heart Investigations Kinases MAP Kinase Signaling System - drug effects MAP Kinase Signaling System - physiology Metabolism Morphology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Pharmaceutical sciences Pharmacology/Toxicology Proto-Oncogene Proteins c-akt - biosynthesis PTEN Phosphohydrolase - biosynthesis Rats Signal transduction
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