Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases
The aim of this study was to prospectively measure liver stiffness with real‐time tissue elastography in patients with nonalcoholic fatty liver diseases (NAFLD) and to compare the result with the clinical assessment of fibrosis using histological stage. One hundred and eighty‐one prospectively enrol...
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| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 2012-10, Vol.56 (4), p.1271-1278 |
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| creator | Ochi, Hironori Hirooka, Masashi Koizumi, Yohei Miyake, Teruki Tokumoto, Yoshio Soga, Yoshiko Tada, Fujimasa Abe, Masanori Hiasa, Yoichi Onji, Morikazu |
| description | The aim of this study was to prospectively measure liver stiffness with real‐time tissue elastography in patients with nonalcoholic fatty liver diseases (NAFLD) and to compare the result with the clinical assessment of fibrosis using histological stage. One hundred and eighty‐one prospectively enrolled patients underwent real‐time tissue elastography, with the first 106 being analyzed as the training set and the remaining 75 being evaluated as the validation set. Hepatic and splenic elastic ratios were calculated and compared with stage of histological fibrosis. Portal hypertension (PH) was assessed. Real‐time tissue elastography cut‐off values by stage in the training set were 2.47 for F1, 2.67 for F2, 3.02 for F3, and 3.36 for F4. Using these cut‐off values, the diagnostic accuracy of hepatic fibrosis in the validation set was 82.6%‐96.0% in all stages. Only portal fibrosis correlated with the hepatic elastic ratio by multivariate analysis. The area under the receiver operating characteristic curve of elastic ratio better correlated than serum fibrosis markers in both early and advanced fibrosis stages. Patients with PH, defined by splenic elasticity, had early fibrosis. Patients with severe PH were found only in the group with cirrhosis. Conclusion: Real‐time tissue elastography is useful in evaluating hepatic fibrosis and PH in patients with NAFLD. (HEPATOLOGY 2012) |
| doi_str_mv | 10.1002/hep.25756 |
| format | Article |
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One hundred and eighty‐one prospectively enrolled patients underwent real‐time tissue elastography, with the first 106 being analyzed as the training set and the remaining 75 being evaluated as the validation set. Hepatic and splenic elastic ratios were calculated and compared with stage of histological fibrosis. Portal hypertension (PH) was assessed. Real‐time tissue elastography cut‐off values by stage in the training set were 2.47 for F1, 2.67 for F2, 3.02 for F3, and 3.36 for F4. Using these cut‐off values, the diagnostic accuracy of hepatic fibrosis in the validation set was 82.6%‐96.0% in all stages. Only portal fibrosis correlated with the hepatic elastic ratio by multivariate analysis. The area under the receiver operating characteristic curve of elastic ratio better correlated than serum fibrosis markers in both early and advanced fibrosis stages. Patients with PH, defined by splenic elasticity, had early fibrosis. Patients with severe PH were found only in the group with cirrhosis. Conclusion: Real‐time tissue elastography is useful in evaluating hepatic fibrosis and PH in patients with NAFLD. (HEPATOLOGY 2012)</description><identifier>ISSN: 0270-9139</identifier><identifier>EISSN: 1527-3350</identifier><identifier>DOI: 10.1002/hep.25756</identifier><identifier>PMID: 22488593</identifier><identifier>CODEN: HPTLD9</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Analysis of Variance ; Biological and medical sciences ; Biopsy, Needle ; Cohort Studies ; Confidence Intervals ; Elasticity Imaging Techniques - methods ; Evaluation Studies as Topic ; Fatty Liver - complications ; Fatty Liver - diagnostic imaging ; Fatty Liver - pathology ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hypertension ; Hypertension, Portal - complications ; Hypertension, Portal - diagnostic imaging ; Hypertension, Portal - pathology ; Immunohistochemistry ; Liver cirrhosis ; Liver Cirrhosis - complications ; Liver Cirrhosis - diagnostic imaging ; Liver Cirrhosis - pathology ; Liver diseases ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Non-alcoholic Fatty Liver Disease ; Odds Ratio ; Other diseases. Semiology ; Predictive Value of Tests ; Prospective Studies ; Reproducibility of Results ; Sensitivity and Specificity ; Severity of Illness Index</subject><ispartof>Hepatology (Baltimore, Md.), 2012-10, Vol.56 (4), p.1271-1278</ispartof><rights>Copyright © 2012 American Association for the Study of Liver Diseases</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 American Association for the Study of Liver Diseases.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5556-787626bfc26555730b97065bd2f0d0aa9c61cfa31c733451bafe18a10107cde93</citedby><cites>FETCH-LOGICAL-c5556-787626bfc26555730b97065bd2f0d0aa9c61cfa31c733451bafe18a10107cde93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhep.25756$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhep.25756$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26701151$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22488593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ochi, Hironori</creatorcontrib><creatorcontrib>Hirooka, Masashi</creatorcontrib><creatorcontrib>Koizumi, Yohei</creatorcontrib><creatorcontrib>Miyake, Teruki</creatorcontrib><creatorcontrib>Tokumoto, Yoshio</creatorcontrib><creatorcontrib>Soga, Yoshiko</creatorcontrib><creatorcontrib>Tada, Fujimasa</creatorcontrib><creatorcontrib>Abe, Masanori</creatorcontrib><creatorcontrib>Hiasa, Yoichi</creatorcontrib><creatorcontrib>Onji, Morikazu</creatorcontrib><title>Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases</title><title>Hepatology (Baltimore, Md.)</title><addtitle>Hepatology</addtitle><description>The aim of this study was to prospectively measure liver stiffness with real‐time tissue elastography in patients with nonalcoholic fatty liver diseases (NAFLD) and to compare the result with the clinical assessment of fibrosis using histological stage. One hundred and eighty‐one prospectively enrolled patients underwent real‐time tissue elastography, with the first 106 being analyzed as the training set and the remaining 75 being evaluated as the validation set. Hepatic and splenic elastic ratios were calculated and compared with stage of histological fibrosis. Portal hypertension (PH) was assessed. Real‐time tissue elastography cut‐off values by stage in the training set were 2.47 for F1, 2.67 for F2, 3.02 for F3, and 3.36 for F4. Using these cut‐off values, the diagnostic accuracy of hepatic fibrosis in the validation set was 82.6%‐96.0% in all stages. Only portal fibrosis correlated with the hepatic elastic ratio by multivariate analysis. The area under the receiver operating characteristic curve of elastic ratio better correlated than serum fibrosis markers in both early and advanced fibrosis stages. Patients with PH, defined by splenic elasticity, had early fibrosis. Patients with severe PH were found only in the group with cirrhosis. Conclusion: Real‐time tissue elastography is useful in evaluating hepatic fibrosis and PH in patients with NAFLD. (HEPATOLOGY 2012)</description><subject>Adult</subject><subject>Aged</subject><subject>Analysis of Variance</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Needle</subject><subject>Cohort Studies</subject><subject>Confidence Intervals</subject><subject>Elasticity Imaging Techniques - methods</subject><subject>Evaluation Studies as Topic</subject><subject>Fatty Liver - complications</subject><subject>Fatty Liver - diagnostic imaging</subject><subject>Fatty Liver - pathology</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension, Portal - complications</subject><subject>Hypertension, Portal - diagnostic imaging</subject><subject>Hypertension, Portal - pathology</subject><subject>Immunohistochemistry</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Cirrhosis - diagnostic imaging</subject><subject>Liver Cirrhosis - pathology</subject><subject>Liver diseases</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Non-alcoholic Fatty Liver Disease</subject><subject>Odds Ratio</subject><subject>Other diseases. Semiology</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Reproducibility of Results</subject><subject>Sensitivity and Specificity</subject><subject>Severity of Illness Index</subject><issn>0270-9139</issn><issn>1527-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1v1DAQBuAIgehSOPAHkCWEBIe0_ljbybFUpUWqlg8VcbQmzoR18cbBTgo58N_xstsiISFOtqVn3pFniuIpo0eMUn68xuGISy3VvWLBJNelEJLeLxaUa1rWTNQHxaOUriml9ZJXD4sDzpdVJWuxKH5-RPDl6DZIRpfShAQ9pDF8iTCsZ9KFSPAG_ASjCz0JHcm98t2SzjUxJJcI9C0ZQhzBk_U8YByxT1vretKHHrwN6-C3BTCOM_HuBiNpXUJImB4XDzrwCZ_sz8Pi05uzq9OL8vLd-dvTk8vSSilVqSutuGo6y1V-a0GbWlMlm5Z3tKUAtVXMdiCY1UIsJWugQ1YBo4xq22ItDouXu9whhm8TptFsXLLoPfQYpmSY1krJumb6_5TWQuapsyrT53_R6zDF_OVtoFIVV1SKrF7tlM3zShE7M0S3gTjnKLNdn8kjNb_Xl-2zfeLUbLC9k7f7yuDFHkCy4LsIvXXpj1OaMiZZdsc79915nP_d0Vycvb9tXe4qXBrxx10FxK9GaaGl-bw6N1qtVop_eG2uxC9408Dg</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Ochi, Hironori</creator><creator>Hirooka, Masashi</creator><creator>Koizumi, Yohei</creator><creator>Miyake, Teruki</creator><creator>Tokumoto, Yoshio</creator><creator>Soga, Yoshiko</creator><creator>Tada, Fujimasa</creator><creator>Abe, Masanori</creator><creator>Hiasa, Yoichi</creator><creator>Onji, Morikazu</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>Wolters Kluwer Health, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201210</creationdate><title>Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases</title><author>Ochi, Hironori ; Hirooka, Masashi ; Koizumi, Yohei ; Miyake, Teruki ; Tokumoto, Yoshio ; Soga, Yoshiko ; Tada, Fujimasa ; Abe, Masanori ; Hiasa, Yoichi ; Onji, Morikazu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5556-787626bfc26555730b97065bd2f0d0aa9c61cfa31c733451bafe18a10107cde93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Analysis of Variance</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Needle</topic><topic>Cohort Studies</topic><topic>Confidence Intervals</topic><topic>Elasticity Imaging Techniques - methods</topic><topic>Evaluation Studies as Topic</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - diagnostic imaging</topic><topic>Fatty Liver - pathology</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Hypertension, Portal - complications</topic><topic>Hypertension, Portal - diagnostic imaging</topic><topic>Hypertension, Portal - pathology</topic><topic>Immunohistochemistry</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Cirrhosis - diagnostic imaging</topic><topic>Liver Cirrhosis - pathology</topic><topic>Liver diseases</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Non-alcoholic Fatty Liver Disease</topic><topic>Odds Ratio</topic><topic>Other diseases. Semiology</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Reproducibility of Results</topic><topic>Sensitivity and Specificity</topic><topic>Severity of Illness Index</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ochi, Hironori</creatorcontrib><creatorcontrib>Hirooka, Masashi</creatorcontrib><creatorcontrib>Koizumi, Yohei</creatorcontrib><creatorcontrib>Miyake, Teruki</creatorcontrib><creatorcontrib>Tokumoto, Yoshio</creatorcontrib><creatorcontrib>Soga, Yoshiko</creatorcontrib><creatorcontrib>Tada, Fujimasa</creatorcontrib><creatorcontrib>Abe, Masanori</creatorcontrib><creatorcontrib>Hiasa, Yoichi</creatorcontrib><creatorcontrib>Onji, Morikazu</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ochi, Hironori</au><au>Hirooka, Masashi</au><au>Koizumi, Yohei</au><au>Miyake, Teruki</au><au>Tokumoto, Yoshio</au><au>Soga, Yoshiko</au><au>Tada, Fujimasa</au><au>Abe, Masanori</au><au>Hiasa, Yoichi</au><au>Onji, Morikazu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases</atitle><jtitle>Hepatology (Baltimore, Md.)</jtitle><addtitle>Hepatology</addtitle><date>2012-10</date><risdate>2012</risdate><volume>56</volume><issue>4</issue><spage>1271</spage><epage>1278</epage><pages>1271-1278</pages><issn>0270-9139</issn><eissn>1527-3350</eissn><coden>HPTLD9</coden><abstract>The aim of this study was to prospectively measure liver stiffness with real‐time tissue elastography in patients with nonalcoholic fatty liver diseases (NAFLD) and to compare the result with the clinical assessment of fibrosis using histological stage. One hundred and eighty‐one prospectively enrolled patients underwent real‐time tissue elastography, with the first 106 being analyzed as the training set and the remaining 75 being evaluated as the validation set. Hepatic and splenic elastic ratios were calculated and compared with stage of histological fibrosis. Portal hypertension (PH) was assessed. Real‐time tissue elastography cut‐off values by stage in the training set were 2.47 for F1, 2.67 for F2, 3.02 for F3, and 3.36 for F4. Using these cut‐off values, the diagnostic accuracy of hepatic fibrosis in the validation set was 82.6%‐96.0% in all stages. Only portal fibrosis correlated with the hepatic elastic ratio by multivariate analysis. The area under the receiver operating characteristic curve of elastic ratio better correlated than serum fibrosis markers in both early and advanced fibrosis stages. Patients with PH, defined by splenic elasticity, had early fibrosis. Patients with severe PH were found only in the group with cirrhosis. Conclusion: Real‐time tissue elastography is useful in evaluating hepatic fibrosis and PH in patients with NAFLD. (HEPATOLOGY 2012)</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>22488593</pmid><doi>10.1002/hep.25756</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Analysis of Variance Biological and medical sciences Biopsy, Needle Cohort Studies Confidence Intervals Elasticity Imaging Techniques - methods Evaluation Studies as Topic Fatty Liver - complications Fatty Liver - diagnostic imaging Fatty Liver - pathology Female Gastroenterology. Liver. Pancreas. Abdomen Humans Hypertension Hypertension, Portal - complications Hypertension, Portal - diagnostic imaging Hypertension, Portal - pathology Immunohistochemistry Liver cirrhosis Liver Cirrhosis - complications Liver Cirrhosis - diagnostic imaging Liver Cirrhosis - pathology Liver diseases Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Multivariate Analysis Non-alcoholic Fatty Liver Disease Odds Ratio Other diseases. Semiology Predictive Value of Tests Prospective Studies Reproducibility of Results Sensitivity and Specificity Severity of Illness Index |
| title | Real-time tissue elastography for evaluation of hepatic fibrosis and portal hypertension in nonalcoholic fatty liver diseases |
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