Transforming growth factor- beta adaptor, beta 2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer

Transforming growth factor beta (TGF- beta ) is an important regulator of cell growth, and loss of TGF- beta signaling is a hallmark of carcinogenesis. The Smad3/4 adaptor protein beta 2-spectrin ( beta 2SP) is emerging as a potent regulator of tumorigenesis through its ability to modulate the tumor...

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Veröffentlicht in:Hepatology (Baltimore, Md.) Md.), 2011-05, Vol.53 (5), p.1676-1684
Hauptverfasser: Baek, Hye Jung, Pishvaian, Michael J, Tang, Yi, Kim, Tae Hyun, Yang, Shaoxian, Zouhairi, Majed El, Mendelson, Jon, Shetty, Kirti, Kallakury, Bhaskar, Berry, Deborah L, Shin, Kyung Hwan, Mishra, Bibhuti, Reddy, EPremkumar, Kim, Sang Soo, Mishra, Lopa
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Sprache:eng
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