A Photoactivatable Platinum(IV) Complex Targeting Genomic DNA and Histone Deacetylases

We report toxic effects of a photoactivatable platinum(IV) complex conjugated with suberoyl‐bis‐hydroxamic acid in tumor cells. The conjugate exerts, after photoactivation, two functions: activity as both a platinum(II) anticancer drug and histone deacetylase (HDAC) inhibitor in cancer cells. This a...

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Veröffentlicht in:	Angewandte Chemie International Edition 2015-11, Vol.54 (48), p.14478-14482
Hauptverfasser:	Kasparkova, Jana, Kostrhunova, Hana, Novakova, Olga, Křikavová, Radka, Vančo, Ján, Trávníček, Zdeněk, Brabec, Viktor
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antitumor agents Cancer Chemotherapy Cytotoxicity Deoxyribonucleic acid DNA DNA - chemistry Genes Genome Histone deacetylase histone deacetylase inhibitors Histone Deacetylases - metabolism Histones Hydroxamic acid Photoactivation Photochemistry Platinum Platinum - chemistry platinum prodrugs Selectivity Toxicity Tumor cells Tumors
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