Long-term hormonal follow-up after human Puumala hantavirus infection
Summary Objective Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome (HFRS) caused by Puumala hantavirus (PUUV). Pituitary haemorrhage and hypopituitarism may complicate recovery from acute NE. Design Forty‐seven of our recent cohort of 58 NE patients volunteered to be re‐examin...
Gespeichert in:
| Veröffentlicht in: | Clinical endocrinology (Oxford) 2016-01, Vol.84 (1), p.85-91 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 91 |
|---|---|
| container_issue | 1 |
| container_start_page | 85 |
| container_title | Clinical endocrinology (Oxford) |
| container_volume | 84 |
| creator | Partanen, Terhi Koivikko, Minna Leisti, Päivi Salmela, Pasi Pääkkö, Eija Karttunen, Ari Sintonen, Harri Risteli, Leila Hautala, Nina Vapalahti, Olli Vaheri, Antti Kauma, Heikki Hautala, Timo |
| description | Summary
Objective
Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome (HFRS) caused by Puumala hantavirus (PUUV). Pituitary haemorrhage and hypopituitarism may complicate recovery from acute NE.
Design
Forty‐seven of our recent cohort of 58 NE patients volunteered to be re‐examined in order to estimate the burden of hormonal deficiency 4 to 8 years after the acute illness. Two patients had suffered from pituitary haemorrhage, but many others exhibited pituitary oedema during their acute infection. In this study, we searched for symptoms of hormonal deficiency, performed hormonal laboratory screening, and most patients underwent pituitary MRI examination.
Results
The pituitary size had diminished in all patients in whom MRI was performed (P |
| doi_str_mv | 10.1111/cen.12863 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1776657332</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3922597311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5603-7e75695179fbbed130b2edf9bb707ac35c10f8bd24d0c798b5e3bed7909fb4953</originalsourceid><addsrcrecordid>eNqN0btOwzAUBmALgaBcBl4ARWKBIfTYru1kRKVcSwEJBJvlJA5NSeJiJ1zeHpe2DEhIeDmDv_MP50doF8MR9q-b6voIk4jTFdTBlLOQEM5WUQcoQAic9zbQpnMTAGARiHW0QTgBAph20GBo6uew0bYKxsZWplZlkJuyNO9hOw1U7n-CcVupOrht_ShVMFZ1o94K27qgqHOdNoWpt9FarkqndxZzCz2cDu775-Hw5uyifzwMU8aBhkILxmOGRZwnic4whYToLI-TRIBQKWUphjxKMtLLIBVxlDBNvRMx-IVezOgWOpjnTq15bbVrZFW4VJelqrVpncRCcM4EpeQflEMUcRHFnu7_ohPTWn-JmWICExL1qFeHc5Va45zVuZzaolL2U2KQsxqkr0F-1-Dt3iKxTSqd_cjl3T3ozsF7UerPv5NkfzBaRobzjcI1-uNnQ9kXyQUVTD6OziS-vrs8uX7qyyv6BbYjnzw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1757122843</pqid></control><display><type>article</type><title>Long-term hormonal follow-up after human Puumala hantavirus infection</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Partanen, Terhi ; Koivikko, Minna ; Leisti, Päivi ; Salmela, Pasi ; Pääkkö, Eija ; Karttunen, Ari ; Sintonen, Harri ; Risteli, Leila ; Hautala, Nina ; Vapalahti, Olli ; Vaheri, Antti ; Kauma, Heikki ; Hautala, Timo</creator><creatorcontrib>Partanen, Terhi ; Koivikko, Minna ; Leisti, Päivi ; Salmela, Pasi ; Pääkkö, Eija ; Karttunen, Ari ; Sintonen, Harri ; Risteli, Leila ; Hautala, Nina ; Vapalahti, Olli ; Vaheri, Antti ; Kauma, Heikki ; Hautala, Timo</creatorcontrib><description>Summary
Objective
Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome (HFRS) caused by Puumala hantavirus (PUUV). Pituitary haemorrhage and hypopituitarism may complicate recovery from acute NE.
Design
Forty‐seven of our recent cohort of 58 NE patients volunteered to be re‐examined in order to estimate the burden of hormonal deficiency 4 to 8 years after the acute illness. Two patients had suffered from pituitary haemorrhage, but many others exhibited pituitary oedema during their acute infection. In this study, we searched for symptoms of hormonal deficiency, performed hormonal laboratory screening, and most patients underwent pituitary MRI examination.
Results
The pituitary size had diminished in all patients in whom MRI was performed (P < 0·001). One patient with acute phase haemorrhage had made a complete recovery while the other continued to require hormonal substitution. In addition, hormonal laboratory abnormalities were observed in nine other patients; these being attributable to several reasons, for example independent peripheral hormonal diseases, side effects of medication or other secondary causes such as obesity. None of them had signs of late‐onset pituitary insufficiency caused by their previous NE. Health‐related quality of life (mean and median 15D score) of patients was comparable to that of age‐standardized general population.
Conclusions
None of our patients had developed obvious late‐onset hypopituitarism despite of the fact that pituitary gland can be affected during acute NE. We recommend requesting a history of hantavirus infection whenever the possibility of pituitary dysfunction is suspected at least in patients originating from regions with high NE infection rate.</description><identifier>ISSN: 0300-0664</identifier><identifier>EISSN: 1365-2265</identifier><identifier>DOI: 10.1111/cen.12863</identifier><identifier>PMID: 26202013</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Female ; Follow-Up Studies ; Hantavirus ; Hemorrhage - complications ; Hemorrhage - diagnosis ; Hemorrhagic Fever with Renal Syndrome - complications ; Hemorrhagic Fever with Renal Syndrome - virology ; Host-Pathogen Interactions ; Humans ; Hypopituitarism - blood ; Hypopituitarism - complications ; Hypopituitarism - diagnosis ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multivariate Analysis ; Pituitary Gland - blood supply ; Pituitary Gland - metabolism ; Pituitary Gland - pathology ; Pituitary Hormones - blood ; Pituitary Hormones - deficiency ; Puumala virus - physiology ; Quality of Life ; Time Factors</subject><ispartof>Clinical endocrinology (Oxford), 2016-01, Vol.84 (1), p.85-91</ispartof><rights>2015 John Wiley & Sons Ltd</rights><rights>2015 John Wiley & Sons Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5603-7e75695179fbbed130b2edf9bb707ac35c10f8bd24d0c798b5e3bed7909fb4953</citedby><cites>FETCH-LOGICAL-c5603-7e75695179fbbed130b2edf9bb707ac35c10f8bd24d0c798b5e3bed7909fb4953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fcen.12863$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fcen.12863$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26202013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Partanen, Terhi</creatorcontrib><creatorcontrib>Koivikko, Minna</creatorcontrib><creatorcontrib>Leisti, Päivi</creatorcontrib><creatorcontrib>Salmela, Pasi</creatorcontrib><creatorcontrib>Pääkkö, Eija</creatorcontrib><creatorcontrib>Karttunen, Ari</creatorcontrib><creatorcontrib>Sintonen, Harri</creatorcontrib><creatorcontrib>Risteli, Leila</creatorcontrib><creatorcontrib>Hautala, Nina</creatorcontrib><creatorcontrib>Vapalahti, Olli</creatorcontrib><creatorcontrib>Vaheri, Antti</creatorcontrib><creatorcontrib>Kauma, Heikki</creatorcontrib><creatorcontrib>Hautala, Timo</creatorcontrib><title>Long-term hormonal follow-up after human Puumala hantavirus infection</title><title>Clinical endocrinology (Oxford)</title><addtitle>Clin Endocrinol</addtitle><description>Summary
Objective
Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome (HFRS) caused by Puumala hantavirus (PUUV). Pituitary haemorrhage and hypopituitarism may complicate recovery from acute NE.
Design
Forty‐seven of our recent cohort of 58 NE patients volunteered to be re‐examined in order to estimate the burden of hormonal deficiency 4 to 8 years after the acute illness. Two patients had suffered from pituitary haemorrhage, but many others exhibited pituitary oedema during their acute infection. In this study, we searched for symptoms of hormonal deficiency, performed hormonal laboratory screening, and most patients underwent pituitary MRI examination.
Results
The pituitary size had diminished in all patients in whom MRI was performed (P < 0·001). One patient with acute phase haemorrhage had made a complete recovery while the other continued to require hormonal substitution. In addition, hormonal laboratory abnormalities were observed in nine other patients; these being attributable to several reasons, for example independent peripheral hormonal diseases, side effects of medication or other secondary causes such as obesity. None of them had signs of late‐onset pituitary insufficiency caused by their previous NE. Health‐related quality of life (mean and median 15D score) of patients was comparable to that of age‐standardized general population.
Conclusions
None of our patients had developed obvious late‐onset hypopituitarism despite of the fact that pituitary gland can be affected during acute NE. We recommend requesting a history of hantavirus infection whenever the possibility of pituitary dysfunction is suspected at least in patients originating from regions with high NE infection rate.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hantavirus</subject><subject>Hemorrhage - complications</subject><subject>Hemorrhage - diagnosis</subject><subject>Hemorrhagic Fever with Renal Syndrome - complications</subject><subject>Hemorrhagic Fever with Renal Syndrome - virology</subject><subject>Host-Pathogen Interactions</subject><subject>Humans</subject><subject>Hypopituitarism - blood</subject><subject>Hypopituitarism - complications</subject><subject>Hypopituitarism - diagnosis</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Pituitary Gland - blood supply</subject><subject>Pituitary Gland - metabolism</subject><subject>Pituitary Gland - pathology</subject><subject>Pituitary Hormones - blood</subject><subject>Pituitary Hormones - deficiency</subject><subject>Puumala virus - physiology</subject><subject>Quality of Life</subject><subject>Time Factors</subject><issn>0300-0664</issn><issn>1365-2265</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0btOwzAUBmALgaBcBl4ARWKBIfTYru1kRKVcSwEJBJvlJA5NSeJiJ1zeHpe2DEhIeDmDv_MP50doF8MR9q-b6voIk4jTFdTBlLOQEM5WUQcoQAic9zbQpnMTAGARiHW0QTgBAph20GBo6uew0bYKxsZWplZlkJuyNO9hOw1U7n-CcVupOrht_ShVMFZ1o94K27qgqHOdNoWpt9FarkqndxZzCz2cDu775-Hw5uyifzwMU8aBhkILxmOGRZwnic4whYToLI-TRIBQKWUphjxKMtLLIBVxlDBNvRMx-IVezOgWOpjnTq15bbVrZFW4VJelqrVpncRCcM4EpeQflEMUcRHFnu7_ohPTWn-JmWICExL1qFeHc5Va45zVuZzaolL2U2KQsxqkr0F-1-Dt3iKxTSqd_cjl3T3ozsF7UerPv5NkfzBaRobzjcI1-uNnQ9kXyQUVTD6OziS-vrs8uX7qyyv6BbYjnzw</recordid><startdate>201601</startdate><enddate>201601</enddate><creator>Partanen, Terhi</creator><creator>Koivikko, Minna</creator><creator>Leisti, Päivi</creator><creator>Salmela, Pasi</creator><creator>Pääkkö, Eija</creator><creator>Karttunen, Ari</creator><creator>Sintonen, Harri</creator><creator>Risteli, Leila</creator><creator>Hautala, Nina</creator><creator>Vapalahti, Olli</creator><creator>Vaheri, Antti</creator><creator>Kauma, Heikki</creator><creator>Hautala, Timo</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>201601</creationdate><title>Long-term hormonal follow-up after human Puumala hantavirus infection</title><author>Partanen, Terhi ; Koivikko, Minna ; Leisti, Päivi ; Salmela, Pasi ; Pääkkö, Eija ; Karttunen, Ari ; Sintonen, Harri ; Risteli, Leila ; Hautala, Nina ; Vapalahti, Olli ; Vaheri, Antti ; Kauma, Heikki ; Hautala, Timo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5603-7e75695179fbbed130b2edf9bb707ac35c10f8bd24d0c798b5e3bed7909fb4953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hantavirus</topic><topic>Hemorrhage - complications</topic><topic>Hemorrhage - diagnosis</topic><topic>Hemorrhagic Fever with Renal Syndrome - complications</topic><topic>Hemorrhagic Fever with Renal Syndrome - virology</topic><topic>Host-Pathogen Interactions</topic><topic>Humans</topic><topic>Hypopituitarism - blood</topic><topic>Hypopituitarism - complications</topic><topic>Hypopituitarism - diagnosis</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Pituitary Gland - blood supply</topic><topic>Pituitary Gland - metabolism</topic><topic>Pituitary Gland - pathology</topic><topic>Pituitary Hormones - blood</topic><topic>Pituitary Hormones - deficiency</topic><topic>Puumala virus - physiology</topic><topic>Quality of Life</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Partanen, Terhi</creatorcontrib><creatorcontrib>Koivikko, Minna</creatorcontrib><creatorcontrib>Leisti, Päivi</creatorcontrib><creatorcontrib>Salmela, Pasi</creatorcontrib><creatorcontrib>Pääkkö, Eija</creatorcontrib><creatorcontrib>Karttunen, Ari</creatorcontrib><creatorcontrib>Sintonen, Harri</creatorcontrib><creatorcontrib>Risteli, Leila</creatorcontrib><creatorcontrib>Hautala, Nina</creatorcontrib><creatorcontrib>Vapalahti, Olli</creatorcontrib><creatorcontrib>Vaheri, Antti</creatorcontrib><creatorcontrib>Kauma, Heikki</creatorcontrib><creatorcontrib>Hautala, Timo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical endocrinology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Partanen, Terhi</au><au>Koivikko, Minna</au><au>Leisti, Päivi</au><au>Salmela, Pasi</au><au>Pääkkö, Eija</au><au>Karttunen, Ari</au><au>Sintonen, Harri</au><au>Risteli, Leila</au><au>Hautala, Nina</au><au>Vapalahti, Olli</au><au>Vaheri, Antti</au><au>Kauma, Heikki</au><au>Hautala, Timo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term hormonal follow-up after human Puumala hantavirus infection</atitle><jtitle>Clinical endocrinology (Oxford)</jtitle><addtitle>Clin Endocrinol</addtitle><date>2016-01</date><risdate>2016</risdate><volume>84</volume><issue>1</issue><spage>85</spage><epage>91</epage><pages>85-91</pages><issn>0300-0664</issn><eissn>1365-2265</eissn><abstract>Summary
Objective
Nephropathia epidemica (NE) is a haemorrhagic fever with renal syndrome (HFRS) caused by Puumala hantavirus (PUUV). Pituitary haemorrhage and hypopituitarism may complicate recovery from acute NE.
Design
Forty‐seven of our recent cohort of 58 NE patients volunteered to be re‐examined in order to estimate the burden of hormonal deficiency 4 to 8 years after the acute illness. Two patients had suffered from pituitary haemorrhage, but many others exhibited pituitary oedema during their acute infection. In this study, we searched for symptoms of hormonal deficiency, performed hormonal laboratory screening, and most patients underwent pituitary MRI examination.
Results
The pituitary size had diminished in all patients in whom MRI was performed (P < 0·001). One patient with acute phase haemorrhage had made a complete recovery while the other continued to require hormonal substitution. In addition, hormonal laboratory abnormalities were observed in nine other patients; these being attributable to several reasons, for example independent peripheral hormonal diseases, side effects of medication or other secondary causes such as obesity. None of them had signs of late‐onset pituitary insufficiency caused by their previous NE. Health‐related quality of life (mean and median 15D score) of patients was comparable to that of age‐standardized general population.
Conclusions
None of our patients had developed obvious late‐onset hypopituitarism despite of the fact that pituitary gland can be affected during acute NE. We recommend requesting a history of hantavirus infection whenever the possibility of pituitary dysfunction is suspected at least in patients originating from regions with high NE infection rate.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26202013</pmid><doi>10.1111/cen.12863</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-0664 |
| ispartof | Clinical endocrinology (Oxford), 2016-01, Vol.84 (1), p.85-91 |
| issn | 0300-0664 1365-2265 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1776657332 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Aged Aged, 80 and over Female Follow-Up Studies Hantavirus Hemorrhage - complications Hemorrhage - diagnosis Hemorrhagic Fever with Renal Syndrome - complications Hemorrhagic Fever with Renal Syndrome - virology Host-Pathogen Interactions Humans Hypopituitarism - blood Hypopituitarism - complications Hypopituitarism - diagnosis Magnetic Resonance Imaging Male Middle Aged Multivariate Analysis Pituitary Gland - blood supply Pituitary Gland - metabolism Pituitary Gland - pathology Pituitary Hormones - blood Pituitary Hormones - deficiency Puumala virus - physiology Quality of Life Time Factors |
| title | Long-term hormonal follow-up after human Puumala hantavirus infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T12%3A32%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Long-term%20hormonal%20follow-up%20after%20human%20Puumala%20hantavirus%20infection&rft.jtitle=Clinical%20endocrinology%20(Oxford)&rft.au=Partanen,%20Terhi&rft.date=2016-01&rft.volume=84&rft.issue=1&rft.spage=85&rft.epage=91&rft.pages=85-91&rft.issn=0300-0664&rft.eissn=1365-2265&rft_id=info:doi/10.1111/cen.12863&rft_dat=%3Cproquest_cross%3E3922597311%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1757122843&rft_id=info:pmid/26202013&rfr_iscdi=true |