The divergent impact of COMT Val158Met on executive function in children with and without attention‐deficit/hyperactivity disorder
Children with attention‐deficit/hyperactivity disorder (ADHD) usually display deficits in executive function (EF), which are primarily mediated by prefrontal cortex (PFC). The functional polymorphism of catechol‐O‐methyltransferase (COMT), Val158Met (rs4680), leads to observed polymorphic difference...
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| creator | Jin, J. Liu, L. Gao, Q. Chan, R. C. K. Li, H. Chen, Y. Wang, Y. Qian, Q. |
| description | Children with attention‐deficit/hyperactivity disorder (ADHD) usually display deficits in executive function (EF), which are primarily mediated by prefrontal cortex (PFC). The functional polymorphism of catechol‐O‐methyltransferase (COMT), Val158Met (rs4680), leads to observed polymorphic differences in the degradation of dopamine within PFC. This study aimed to explore the effect of rs4680 on EF using case–control design. In addition, considering the dynamic development of EF, we also attempted to investigate whether this genetic influence changes during development or not. A total of 597 ADHD children and 154 unaffected controls were recruited. The EF was evaluated using Rey–Osterrieth complex figure test (RCFT), trail making test (TMT) and Stroop color and word test for working memory, shifting and inhibition. Association between genotype and EF was analyzed using analysis of covariance (ancova). The results showed significant interaction effect of genotype and ADHD diagnosis on RCFT performance (P |
| doi_str_mv | 10.1111/gbb.12270 |
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We found that association existed between rs4680 genotypes and executive function which was divergent in attention‐deficit/hyperactivity disorder children and controls but no ‘when’ effect.</description><identifier>ISSN: 1601-1848</identifier><identifier>EISSN: 1601-183X</identifier><identifier>DOI: 10.1111/gbb.12270</identifier><identifier>PMID: 26560848</identifier><identifier>CODEN: GBBEAO</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>ADHD ; Adolescent ; Attention Deficit Disorder with Hyperactivity - genetics ; Catechol O-Methyltransferase - metabolism ; Child ; COMT ; development ; executive function ; Executive Function - physiology ; Female ; Genotype ; Humans ; Male ; Memory, Short-Term - physiology ; Neuropsychological Tests ; Polymorphism, Genetic - genetics ; Prefrontal Cortex - metabolism ; Val158Met</subject><ispartof>Genes, brain and behavior, 2016-02, Vol.15 (2), p.271-279</ispartof><rights>2015 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society</rights><rights>2015 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society.</rights><rights>2016 John Wiley & Sons Ltd and International Behavioural and Neural Genetics Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4560-5d4627dfde81fabc8ec42ddf6563719bf4a8aa808aa5b0626d586834c687c1e53</citedby><cites>FETCH-LOGICAL-c4560-5d4627dfde81fabc8ec42ddf6563719bf4a8aa808aa5b0626d586834c687c1e53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fgbb.12270$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fgbb.12270$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,11542,27903,27904,45553,45554,46030,46454</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fgbb.12270$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26560848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jin, J.</creatorcontrib><creatorcontrib>Liu, L.</creatorcontrib><creatorcontrib>Gao, Q.</creatorcontrib><creatorcontrib>Chan, R. C. K.</creatorcontrib><creatorcontrib>Li, H.</creatorcontrib><creatorcontrib>Chen, Y.</creatorcontrib><creatorcontrib>Wang, Y.</creatorcontrib><creatorcontrib>Qian, Q.</creatorcontrib><title>The divergent impact of COMT Val158Met on executive function in children with and without attention‐deficit/hyperactivity disorder</title><title>Genes, brain and behavior</title><addtitle>Genes Brain Behav</addtitle><description>Children with attention‐deficit/hyperactivity disorder (ADHD) usually display deficits in executive function (EF), which are primarily mediated by prefrontal cortex (PFC). The functional polymorphism of catechol‐O‐methyltransferase (COMT), Val158Met (rs4680), leads to observed polymorphic differences in the degradation of dopamine within PFC. This study aimed to explore the effect of rs4680 on EF using case–control design. In addition, considering the dynamic development of EF, we also attempted to investigate whether this genetic influence changes during development or not. A total of 597 ADHD children and 154 unaffected controls were recruited. The EF was evaluated using Rey–Osterrieth complex figure test (RCFT), trail making test (TMT) and Stroop color and word test for working memory, shifting and inhibition. Association between genotype and EF was analyzed using analysis of covariance (ancova). The results showed significant interaction effect of genotype and ADHD diagnosis on RCFT performance (P < 0.001). However, the associated genotypes between ADHD and controls were divergent. In ADHD, the Met carriers performed better than the Val homozygotes on detail immediate [(10.38 ± 6.90) vs. (9.33 ± 6.92), P = 0.007] and detail delay [(9.96 ± 6.86) vs. (8.86 ± 6.89), P = 0.004], while Val homozygotes showed better performance compared with Met carrier controls [for detail immediate (14.55 ± 6.18) vs. (11.10 ± 6.45), P<0.001; for detail delay (14.31 ± 5.96) vs. (11.31 ± 6.96), P = 0.001]. We did not find significant interaction between genetic variant and development. COMT Val158Met (rs4680) may have divergent effect on working memory in ADHD children compared with healthy controls.
We found that association existed between rs4680 genotypes and executive function which was divergent in attention‐deficit/hyperactivity disorder children and controls but no ‘when’ effect.</description><subject>ADHD</subject><subject>Adolescent</subject><subject>Attention Deficit Disorder with Hyperactivity - genetics</subject><subject>Catechol O-Methyltransferase - metabolism</subject><subject>Child</subject><subject>COMT</subject><subject>development</subject><subject>executive function</subject><subject>Executive Function - physiology</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Memory, Short-Term - physiology</subject><subject>Neuropsychological Tests</subject><subject>Polymorphism, Genetic - genetics</subject><subject>Prefrontal Cortex - metabolism</subject><subject>Val158Met</subject><issn>1601-1848</issn><issn>1601-183X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9KJDEQxoPsoq568AUksBf3ME7S3UnHozP4DxQvo3hr0knFifR0j0lanZuHfYB9Rp_E0nE9CII5VIqPH19V8RGyzdkexze8qes9nmUlWyHrXDI-4Cq__vHRF2qN_IrxljFe5oqvkrVMCslQXyd_J1Og1t9DuIE2UT-ba5No5-j44nxCr3TDhToHVFoKj2D6hCh1fWuSR8m31Ex9YwO09MGnKdWtfWu6PlGdEloi9vz0z4LzxqfhdDGHgBP8vU8LnBu7YCFskp9ONxG23v8Ncnl0OBmfDM4ujk_HB2cDU-C-A2ELmZXWWVDc6dooMEVmrcNj8pLv167QSmvFsIiayUxaoaTKCyNVaTiIfIPsLn3nobvrIaZq5qOBptEtdH2seFlKKUTBvoPKLC9ysS8R_f0Jve360OIhrxRHTgiF1J8lZUIXYwBXzYOf6bCoOKteU6wwxeotRWR33h37egb2g_wfGwLDJfDgG1h87VQdj0ZLyxflZafn</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Jin, J.</creator><creator>Liu, L.</creator><creator>Gao, Q.</creator><creator>Chan, R. C. K.</creator><creator>Li, H.</creator><creator>Chen, Y.</creator><creator>Wang, Y.</creator><creator>Qian, Q.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley & Sons, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201602</creationdate><title>The divergent impact of COMT Val158Met on executive function in children with and without attention‐deficit/hyperactivity disorder</title><author>Jin, J. ; Liu, L. ; Gao, Q. ; Chan, R. C. K. ; Li, H. ; Chen, Y. ; Wang, Y. ; Qian, Q.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4560-5d4627dfde81fabc8ec42ddf6563719bf4a8aa808aa5b0626d586834c687c1e53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>ADHD</topic><topic>Adolescent</topic><topic>Attention Deficit Disorder with Hyperactivity - genetics</topic><topic>Catechol O-Methyltransferase - metabolism</topic><topic>Child</topic><topic>COMT</topic><topic>development</topic><topic>executive function</topic><topic>Executive Function - physiology</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Memory, Short-Term - physiology</topic><topic>Neuropsychological Tests</topic><topic>Polymorphism, Genetic - genetics</topic><topic>Prefrontal Cortex - metabolism</topic><topic>Val158Met</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jin, J.</creatorcontrib><creatorcontrib>Liu, L.</creatorcontrib><creatorcontrib>Gao, Q.</creatorcontrib><creatorcontrib>Chan, R. C. K.</creatorcontrib><creatorcontrib>Li, H.</creatorcontrib><creatorcontrib>Chen, Y.</creatorcontrib><creatorcontrib>Wang, Y.</creatorcontrib><creatorcontrib>Qian, Q.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Genes, brain and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Jin, J.</au><au>Liu, L.</au><au>Gao, Q.</au><au>Chan, R. C. K.</au><au>Li, H.</au><au>Chen, Y.</au><au>Wang, Y.</au><au>Qian, Q.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The divergent impact of COMT Val158Met on executive function in children with and without attention‐deficit/hyperactivity disorder</atitle><jtitle>Genes, brain and behavior</jtitle><addtitle>Genes Brain Behav</addtitle><date>2016-02</date><risdate>2016</risdate><volume>15</volume><issue>2</issue><spage>271</spage><epage>279</epage><pages>271-279</pages><issn>1601-1848</issn><eissn>1601-183X</eissn><coden>GBBEAO</coden><abstract>Children with attention‐deficit/hyperactivity disorder (ADHD) usually display deficits in executive function (EF), which are primarily mediated by prefrontal cortex (PFC). The functional polymorphism of catechol‐O‐methyltransferase (COMT), Val158Met (rs4680), leads to observed polymorphic differences in the degradation of dopamine within PFC. This study aimed to explore the effect of rs4680 on EF using case–control design. In addition, considering the dynamic development of EF, we also attempted to investigate whether this genetic influence changes during development or not. A total of 597 ADHD children and 154 unaffected controls were recruited. The EF was evaluated using Rey–Osterrieth complex figure test (RCFT), trail making test (TMT) and Stroop color and word test for working memory, shifting and inhibition. Association between genotype and EF was analyzed using analysis of covariance (ancova). The results showed significant interaction effect of genotype and ADHD diagnosis on RCFT performance (P < 0.001). However, the associated genotypes between ADHD and controls were divergent. In ADHD, the Met carriers performed better than the Val homozygotes on detail immediate [(10.38 ± 6.90) vs. (9.33 ± 6.92), P = 0.007] and detail delay [(9.96 ± 6.86) vs. (8.86 ± 6.89), P = 0.004], while Val homozygotes showed better performance compared with Met carrier controls [for detail immediate (14.55 ± 6.18) vs. (11.10 ± 6.45), P<0.001; for detail delay (14.31 ± 5.96) vs. (11.31 ± 6.96), P = 0.001]. We did not find significant interaction between genetic variant and development. COMT Val158Met (rs4680) may have divergent effect on working memory in ADHD children compared with healthy controls.
We found that association existed between rs4680 genotypes and executive function which was divergent in attention‐deficit/hyperactivity disorder children and controls but no ‘when’ effect.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>26560848</pmid><doi>10.1111/gbb.12270</doi><tpages>9</tpages></addata></record> |
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| subjects | ADHD Adolescent Attention Deficit Disorder with Hyperactivity - genetics Catechol O-Methyltransferase - metabolism Child COMT development executive function Executive Function - physiology Female Genotype Humans Male Memory, Short-Term - physiology Neuropsychological Tests Polymorphism, Genetic - genetics Prefrontal Cortex - metabolism Val158Met |
| title | The divergent impact of COMT Val158Met on executive function in children with and without attention‐deficit/hyperactivity disorder |
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