Monitoring Combretastatin A4-induced tumor hypoxia and hemodynamic changes using endogenous MR contrast and DCE-MRI

Purpose To benchmark MOBILE (Mapping of Oxygen By Imaging Lipid relaxation Enhancement), a recent noninvasive MR method of mapping changes in tumor hypoxia, electron paramagnetic resonance (EPR) oximetry, and dynamic contrast‐enhanced MRI (DCE‐MRI) as biomarkers of changes in tumor hemodynamics indu...

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Veröffentlicht in:	Magnetic resonance in medicine 2016-02, Vol.75 (2), p.866-872
Hauptverfasser:	Colliez, Florence, Fruytier, Anne-Catherine, Magat, Julie, Neveu, Marie-Aline, Cani, Patrice D., Gallez, Bernard, Jordan, Bénédicte F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Biomarkers, Tumor - metabolism Breast cancer CA4 Contrast Media DCE-MRI Electron paramagnetic resonance Electron spin resonance Electron Spin Resonance Spectroscopy - methods Female Hemodynamics Hemodynamics - drug effects Hypoxia Lipids Magnetic resonance imaging Magnetic Resonance Imaging - methods Mammary Neoplasms, Experimental - metabolism Mapping Mice Mice, Nude MOBILE Neurotrophin 2 Oximetry Oximetry - methods Oxygen - metabolism Oxygenation Stilbenes - pharmacology tumor Tumors
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