Interleukin-27-Producing CD4+ T Cells Regulate Protective Immunity during Malaria Parasite Infection

Interleukin-27 (IL-27) is a heterodimeric regulatory cytokine of the IL-12 family, which is produced by macrophages, dendritic cells, and B cells upon stimulation through innate immune receptors. Here, we described regulatory CD4+ T cells that produce IL-27 in response to T cell receptor stimulation...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2016-03, Vol.44 (3), p.672-682
Hauptverfasser:	Kimura, Daisuke, Miyakoda, Mana, Kimura, Kazumi, Honma, Kiri, Hara, Hiromitsu, Yoshida, Hiroki, Yui, Katsuyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens CD4-Positive T-Lymphocytes - parasitology CD4-Positive T-Lymphocytes - physiology Cell Proliferation - genetics Cells, Cultured Cytokines Cytokines - metabolism Dendritic cells Experiments Immunity, Innate Infections Infectious diseases Interleukin-27 - genetics Interleukin-27 - metabolism Lymphocytes Malaria - immunology Mice Mice, Inbred C57BL Mice, Knockout Parasites Plasmodium berghei - immunology Receptors, Antigen, T-Cell - metabolism Receptors, Cytokine - genetics Receptors, Cytokine - metabolism Regulation T cell receptors T-Lymphocytes, Regulatory - parasitology T-Lymphocytes, Regulatory - physiology
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