Macrophage plasticity and polarization in liver homeostasis and pathology
Resident and recruited macrophages are key players in the homeostatic function of the liver and in its response to tissue damage. In response to environmental signals, macrophages undergo polarized activation to M1 or M2 or M2‐like activation states. These are extremes of a spectrum in a universe of...
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| Veröffentlicht in: | Hepatology (Baltimore, Md.) Md.), 2014-05, Vol.59 (5), p.2034-2042 |
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| container_title | Hepatology (Baltimore, Md.) |
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| creator | Sica, Antonio Invernizzi, Pietro Mantovani, Alberto |
| description | Resident and recruited macrophages are key players in the homeostatic function of the liver and in its response to tissue damage. In response to environmental signals, macrophages undergo polarized activation to M1 or M2 or M2‐like activation states. These are extremes of a spectrum in a universe of activation states. Progress has been made in understanding the molecular mechanisms underlying the polarized activation of mononuclear phagocytes. Resident and recruited macrophages are a key component of diverse homeostatic and pathological responses of hepatic tissue. Polarized macrophages interact with hepatic progenitor cells, integrate metabolic adaptation, mediate responses to infectious agents, orchestrate fibrosis in a yin‐yang interaction with hepatic stellate cells, and are a key component of tumor‐promoting inflammation. Conclusion: A better understanding of macrophage diversity and plasticity in liver homeostasis and pathology may pave the way to innovative diagnostic and therapeutic approaches. (Hepatology 2014;59:2034–2042) |
| doi_str_mv | 10.1002/hep.26754 |
| format | Article |
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In response to environmental signals, macrophages undergo polarized activation to M1 or M2 or M2‐like activation states. These are extremes of a spectrum in a universe of activation states. Progress has been made in understanding the molecular mechanisms underlying the polarized activation of mononuclear phagocytes. Resident and recruited macrophages are a key component of diverse homeostatic and pathological responses of hepatic tissue. Polarized macrophages interact with hepatic progenitor cells, integrate metabolic adaptation, mediate responses to infectious agents, orchestrate fibrosis in a yin‐yang interaction with hepatic stellate cells, and are a key component of tumor‐promoting inflammation. Conclusion: A better understanding of macrophage diversity and plasticity in liver homeostasis and pathology may pave the way to innovative diagnostic and therapeutic approaches. 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In response to environmental signals, macrophages undergo polarized activation to M1 or M2 or M2‐like activation states. These are extremes of a spectrum in a universe of activation states. Progress has been made in understanding the molecular mechanisms underlying the polarized activation of mononuclear phagocytes. Resident and recruited macrophages are a key component of diverse homeostatic and pathological responses of hepatic tissue. Polarized macrophages interact with hepatic progenitor cells, integrate metabolic adaptation, mediate responses to infectious agents, orchestrate fibrosis in a yin‐yang interaction with hepatic stellate cells, and are a key component of tumor‐promoting inflammation. Conclusion: A better understanding of macrophage diversity and plasticity in liver homeostasis and pathology may pave the way to innovative diagnostic and therapeutic approaches. (Hepatology 2014;59:2034–2042)</description><subject>Animals</subject><subject>Cell Polarity</subject><subject>Hepatology</subject><subject>Homeostasis</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - pathology</subject><subject>Liver - physiology</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver Neoplasms - etiology</subject><subject>Macrophage Activation</subject><subject>Macrophages - physiology</subject><subject>Pathology</subject><subject>Yin-Yang</subject><issn>0270-9139</issn><issn>1527-3350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0U1Lw0AQBuBFFFurB_-ABLx4STv7lc0epVRbqOhBz2GTbJotSTZmEyX-etMPPXjxNAPzMDDzInSNYYoByCzX9ZQEgrMTNMacCJ9SDqdoDESALzGVI3Th3BYAJCPhORoRhgcHbIxWTyppbJ2rjfbqQrnWJKbtPVWlXm0L1Zgv1RpbeabyCvOhGy-3pbauVc64g1Jtbgu76S_RWaYKp6-OdYLeHhav86W_fn5cze_XfsI4ZT5PZQoBA5xlSaiAhgELMYmFDFKmRRIrzTLOZZpKGmac0SxWkOJYiQQSAXFIJ-jusLdu7HunXRuVxiW6KFSlbeciLEQQcGCM_k85liTABMhAb__Qre2aajhkp0JO6UAHdXNUXVzqNKobU6qmj37-OYDZAXyaQve_cwzRLqhoCCraBxUtFy_7hn4DObaEGQ</recordid><startdate>201405</startdate><enddate>201405</enddate><creator>Sica, Antonio</creator><creator>Invernizzi, Pietro</creator><creator>Mantovani, Alberto</creator><general>Wolters Kluwer Health, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201405</creationdate><title>Macrophage plasticity and polarization in liver homeostasis and pathology</title><author>Sica, Antonio ; Invernizzi, Pietro ; Mantovani, Alberto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4534-5d9d06401ffc8a03864812b796d4e7cbae4f559dd938f543fba0d1ba7c0c70b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Cell Polarity</topic><topic>Hepatology</topic><topic>Homeostasis</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - pathology</topic><topic>Liver - physiology</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver Neoplasms - etiology</topic><topic>Macrophage Activation</topic><topic>Macrophages - physiology</topic><topic>Pathology</topic><topic>Yin-Yang</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sica, Antonio</creatorcontrib><creatorcontrib>Invernizzi, Pietro</creatorcontrib><creatorcontrib>Mantovani, Alberto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Hepatology (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sica, Antonio</au><au>Invernizzi, Pietro</au><au>Mantovani, Alberto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Macrophage plasticity and polarization in liver homeostasis and pathology</atitle><jtitle>Hepatology (Baltimore, Md.)</jtitle><addtitle>Hepatology</addtitle><date>2014-05</date><risdate>2014</risdate><volume>59</volume><issue>5</issue><spage>2034</spage><epage>2042</epage><pages>2034-2042</pages><issn>0270-9139</issn><eissn>1527-3350</eissn><coden>HPTLD9</coden><abstract>Resident and recruited macrophages are key players in the homeostatic function of the liver and in its response to tissue damage. 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| ispartof | Hepatology (Baltimore, Md.), 2014-05, Vol.59 (5), p.2034-2042 |
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| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Cell Polarity Hepatology Homeostasis Humans Liver Liver - pathology Liver - physiology Liver Cirrhosis - etiology Liver Neoplasms - etiology Macrophage Activation Macrophages - physiology Pathology Yin-Yang |
| title | Macrophage plasticity and polarization in liver homeostasis and pathology |
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