The nitric oxide donor sodium nitroprusside attenuates recognition memory deficits and social withdrawal produced by the NMDA receptor antagonist ketamine and induces anxiolytic-like behaviour in rats

Rationale Experimental evidence indicates that the non-competitive N -methyl- d -aspartate (NMDA) receptor antagonist ketamine impairs cognition and can mimic certain aspects of positive and negative symptoms of schizophrenia in rodents. Nitric oxide (NO) is considered as an intracellular messenger...

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Veröffentlicht in:	Psychopharmacology 2016-03, Vol.233 (6), p.1045-1054
Hauptverfasser:	Trevlopoulou, Aikaterini, Touzlatzi, Ntilara, Pitsikas, Nikolaos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal behavior Animals Anti-Anxiety Agents - pharmacology Anxiety - chemically induced Behavior, Animal - drug effects Biomedical and Life Sciences Biomedicine Dosage and administration Excitatory Amino Acid Antagonists Health aspects Ketamine Male Memory disorders Memory Disorders - chemically induced Memory Disorders - drug therapy Motor Activity - drug effects N-methyl-D-aspartate N-Methylaspartate - pharmacology Neurosciences Nitric oxide Nitric Oxide Donors - pharmacology Nitric Oxide Donors - therapeutic use Nitroprusside - pharmacology Nitroprusside - therapeutic use Original Investigation Pharmacology/Toxicology Prevention Psychiatry Psychopharmacology Psychotropic drugs Rats Rats, Wistar Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Recognition (Psychology) - drug effects Rodents Schizophrenia Social Behavior
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