Design of Polyepitope DNA Vaccine against Breast Carcinoma Cells and Analysis of Its Expression in Dendritic Cells

Polyepitope DNA vaccine inducing T-cell-mediated immune response against cancer-specific antigens is a promising tool for selective elimination of tumor cells. Breast cancer-specific polyepitope DNA vaccine was designed using TEpredict and PolyCTLDesigner software on the basis of immunogenic peptide...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-02, Vol.160 (4), p.486-490
Hauptverfasser:	Nazarkina, Zh. K., Khar’kova, M. V., Antonets, D. V., Morozkin, E. S., Bazhan, S. I., Karpenko, L. I., Vlasov, V. V., Ilyichev, A. A., Laktionov, P. P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - immunology Breast Neoplasms - prevention & control Cancer Cancer vaccines Cancer Vaccines - immunology Cell Biology Cell Line, Tumor Dendritic cells Dendritic Cells - immunology DNA Genetic aspects HEK293 Cells Humans Immunotherapy - methods Interleukin-10 - biosynthesis Interleukin-6 - biosynthesis Internal Medicine Laboratory Medicine Mammaglobin A - immunology Pathology Peptides Polymerase Chain Reaction Receptor, ErbB-2 - immunology Receptors, Antigen, T-Cell - immunology T cells T-Lymphocytes, Cytotoxic - immunology Tumor antigens Vaccines, DNA - immunology
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