Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular–Subventricular Zone
In many animal species, the production of new neurons (neurogenesis) occurs throughout life, in a specialized germinal region called the ventricular–subventricular zone (V-SVZ). In this region, neural stem cells undergo self-renewal and generate neural progenitor cells and new neurons. In the olfact...
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| Veröffentlicht in: | Neurochemical research 2016-02, Vol.41 (1-2), p.222-230 |
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| creator | Hirota, Yuki Sawada, Masato Huang, Shih-hui Ogino, Takashi Ohata, Shinya Kubo, Akiharu Sawamoto, Kazunobu |
| description | In many animal species, the production of new neurons (neurogenesis) occurs throughout life, in a specialized germinal region called the ventricular–subventricular zone (V-SVZ). In this region, neural stem cells undergo self-renewal and generate neural progenitor cells and new neurons. In the olfactory system, the new neurons migrate rostrally toward the olfactory bulb, where they differentiate into mature interneurons. V-SVZ-derived new neurons can also migrate toward sites of brain injury, where they contribute to neural regeneration. Recent studies indicate that two major branches of the Wnt signaling pathway, the Wnt/β-catenin and Wnt/planar cell polarity pathways, play essential roles in various facets of adult neurogenesis. Here, we review the Wnt signaling-mediated regulation of adult neurogenesis in the V-SVZ under physiological and pathological conditions. |
| doi_str_mv | 10.1007/s11064-015-1766-z |
| format | Article |
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In this region, neural stem cells undergo self-renewal and generate neural progenitor cells and new neurons. In the olfactory system, the new neurons migrate rostrally toward the olfactory bulb, where they differentiate into mature interneurons. V-SVZ-derived new neurons can also migrate toward sites of brain injury, where they contribute to neural regeneration. Recent studies indicate that two major branches of the Wnt signaling pathway, the Wnt/β-catenin and Wnt/planar cell polarity pathways, play essential roles in various facets of adult neurogenesis. 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| subjects | Animals beta Catenin - metabolism Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cell Differentiation Cell Movement Cell Polarity Cell Proliferation Cerebral Ventricles - metabolism Mice Neurochemistry Neurology Neurons - cytology Neurosciences Original Paper Signal Transduction Wnt Proteins - metabolism |
| title | Roles of Wnt Signaling in the Neurogenic Niche of the Adult Mouse Ventricular–Subventricular Zone |
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