Unsaturated compounds induce up-regulation of CD86 on dendritic cells in the in vitro sensitization assay LCSA

Unsaturated compounds are known to cause false-positive reactions in the local lymph node assay (LLNA) but not in the guinea pig maximization test. We have tested a panel of substances (succinic acid, undecylenic acid, 1-octyn-3-ol, fumaric acid, maleic acid, linoleic acid, oleic acid, alpha-linolen...

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Veröffentlicht in:	Archives of toxicology 2016-04, Vol.90 (4), p.927-936
Hauptverfasser:	Frohwein, Thomas Armin, Sonnenburg, Anna, Zuberbier, Torsten, Stahlmann, Ralf, Schreiner, Maximilian
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B7-2 Antigen - metabolism Bioassays Biomedical and Life Sciences Biomedicine Cellular biology Coculture Techniques - methods Dendritic Cells - drug effects Dendritic Cells - immunology Environmental Health False Positive Reactions Fatty Acids, Unsaturated - immunology Fatty Acids, Unsaturated - toxicity Guinea Pigs Humans Immunotoxicology Keratinocytes - cytology Keratinocytes - drug effects Keratinocytes - immunology Local Lymph Node Assay Occupational Medicine/Industrial Medicine Pharmacology/Toxicology Skin Tests - methods Succinic Acid - immunology Succinic Acid - toxicity Toxicology Up-Regulation - drug effects
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