Oligonucleotide-Based Mimetics of Hepatocyte Growth Factor

Oligonucleotide‐based hepatocyte growth factor (HGF) mimetics are described. A DNA aptamer to Met, a cognate receptor for HGF, was shown to induce Met activation when used in dimer form. The most potent aptamer dimer, ss‐0, which was composed solely of 100‐mer single‐stranded DNA, exhibited nanomola...

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Veröffentlicht in:	Angewandte Chemie International Edition 2016-01, Vol.55 (2), p.579-582
Hauptverfasser:	Ueki, Ryosuke, Ueki, Ayaka, Kanda, Naoto, Sando, Shinsuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Aptamers Base Sequence c-Met protein Cell Line Deoxyribonucleic acid Design factors Dimerization DNA DNA nanotechnology Growth factors Hepatocyte growth factor Hepatocyte Growth Factor - chemistry Humans Molecular Mimicry Nanostructure Oligonucleotides Oligonucleotides - chemistry Oligonucleotides - genetics Phosphorylation Proto-Oncogene Proteins c-met - genetics receptors Reproduction signal transduction Single-stranded DNA
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