Genetic Variants Influencing Joint Damage in Mexican Americans and European Americans With Rheumatoid Arthritis

ABSTRACT Joint destruction in rheumatoid arthritis (RA) is heritable, but knowledge on specific genetic determinants of joint damage in RA is limited. We have used the Immunochip array to examine whether genetic variants influence variation in joint damage in a cohort of Mexican Americans (MA) and E...

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Veröffentlicht in:	Genetic epidemiology 2015-12, Vol.39 (8), p.678-688
Hauptverfasser:	Arya, Rector, del Rincon, Inmaculada, Farook, Vidya S., Restrepo, Jose F, Winnier, Diedre A, Fourcaudot, Marcel J, Battafarano, Daniel F, de Almeida, Marcio, Kumar, Satish, Curran, Joanne E, Jenkinson, Christopher P., Blangero, John, Duggirala, Ravindranath, Escalante, Agustin
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis, Rheumatoid - ethnology Arthritis, Rheumatoid - genetics Arthritis, Rheumatoid - pathology CARD Signaling Adaptor Proteins - genetics European Americans Female genetic association Genetic Association Studies - methods Genetic Predisposition to Disease Genotype Humans joint damage Joints - pathology Male Mexican Americans Mexican Americans - genetics Middle Aged NF-kappaB-Inducing Kinase Phenotype Polymorphism, Single Nucleotide - genetics Protein Serine-Threonine Kinases - genetics rheumatoid arthritis susceptibility loci United States White People - genetics
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