Functional characterization, localization, and inhibitor sensitivity of the TPR-FGFR1 fusion in 8p11 myeloproliferative syndrome

Myeloid and lymphoid neoplasms with fibroblast growth factor receptor 1 (FGFR1) abnormalities, also known as 8p11 myeloproliferative syndrome (EMS), represent rare and aggressive disorders, associated with chromosomal aberrations that lead to the fusion of FGFR1 to different partner genes. We report...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Genes chromosomes & cancer 2016-01, Vol.55 (1), p.60-68
Hauptverfasser:	Malli, Theodora, Buxhofer-Ausch, Veronika, Rammer, Melanie, Erdel, Martin, Kranewitter, Wolfgang, Rumpold, Holger, Marschon, Renate, Deutschbauer, Sabine, Simonitsch-Klupp, Ingrid, Valent, Peter, Muellner-Ammer, Kirsten, Sebesta, Christian, Birkner, Thomas, Webersinke, Gerald
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Chromosomes, Human, Pair 8 - genetics Cytoplasm - metabolism Humans Imidazoles - pharmacology Imidazoles - therapeutic use Male Middle Aged Mutagenesis, Insertional Myeloproliferative Disorders - drug therapy Myeloproliferative Disorders - genetics Nuclear Pore Complex Proteins - genetics Nuclear Pore Complex Proteins - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Phenylurea Compounds - pharmacology Phenylurea Compounds - therapeutic use Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Pyridazines - pharmacology Pyridazines - therapeutic use Pyrimidines - pharmacology Pyrimidines - therapeutic use Receptor, Fibroblast Growth Factor, Type 1 - genetics Receptor, Fibroblast Growth Factor, Type 1 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!