Access and latency to first antipsychotic treatment in Italian patients with schizophrenia and other schizophrenic spectrum disorders across different epochs
Background The duration of untreated illness (DUI) is a measure to express the latency to first psychopharmacological treatment: it differs among psychiatric disorders, being influenced by several illness‐intrinsic and environmental factors. The present study aimed to assess differences in DUI and r...
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| Veröffentlicht in: | Human psychopharmacology 2016-03, Vol.31 (2), p.113-120 |
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| creator | Palazzo, Maria Carlotta Arici, Chiara Dell'Osso, Bernardo Cremaschi, Laura Grancini, Benedetta Camuri, Giulia Benatti, Beatrice Oldani, Lucio Dobrea, Cristina Cattaneo, Alma Altamura, Alfredo Carlo |
| description | Background
The duration of untreated illness (DUI) is a measure to express the latency to first psychopharmacological treatment: it differs among psychiatric disorders, being influenced by several illness‐intrinsic and environmental factors. The present study aimed to assess differences in DUI and related variables in patients with schizophrenia (SKZ) versus other schizophrenic spectrum disorders (SSDs) across different epochs.
Methods
101 SKZ or SSD patients were assessed with respect to DUI and related variables through clinical interview and questionnaire.
Results
Patients with SKZ showed earlier ages of onset, first diagnosis and first antipsychotic treatment compared with patients with other SSDs (F = 11.02, p |
| doi_str_mv | 10.1002/hup.2518 |
| format | Article |
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The duration of untreated illness (DUI) is a measure to express the latency to first psychopharmacological treatment: it differs among psychiatric disorders, being influenced by several illness‐intrinsic and environmental factors. The present study aimed to assess differences in DUI and related variables in patients with schizophrenia (SKZ) versus other schizophrenic spectrum disorders (SSDs) across different epochs.
Methods
101 SKZ or SSD patients were assessed with respect to DUI and related variables through clinical interview and questionnaire.
Results
Patients with SKZ showed earlier ages of onset, first diagnosis and first antipsychotic treatment compared with patients with other SSDs (F = 11.02, p < 0.001; F = 12.68, p < 0.001; F = 13.74, p < 0.001, respectively) who showed an earlier access to benzodiazepines than SKZ patients (F = 6.547; p < 0.05). Dividing the total sample by the epoch of onset (before 1978; between 1978–2000; after 2000) showed a significantly later age of onset in patients with onset within the two most recent epochs (F = 7.46; p < 0.001) and a reduced DUI across epochs (from 144 to 41 to 20 months, on average; F = 11.78, p < 0.001).
Conclusion
Schizophrenic patients showed earlier onset and longer DUI compared with patients with other SSDs. Data on the total sample showed a later age of onset and a reduced DUI across epochs. Copyright © 2016 John Wiley & Sons, Ltd.]]></description><identifier>ISSN: 0885-6222</identifier><identifier>EISSN: 1099-1077</identifier><identifier>DOI: 10.1002/hup.2518</identifier><identifier>PMID: 26948428</identifier><identifier>CODEN: HUPSEC</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; Age of Onset ; duration of untreated illness (DUI) ; epochs of onset ; Female ; Humans ; Italy - epidemiology ; Male ; Middle Aged ; Psychotic Disorders - drug therapy ; Psychotic Disorders - epidemiology ; schizophrenia (SKZ) ; Schizophrenia - drug therapy ; Schizophrenia - epidemiology ; schizophrenic spectrum disorders (SSDs) ; Time Factors ; Time-to-Treatment - trends</subject><ispartof>Human psychopharmacology, 2016-03, Vol.31 (2), p.113-120</ispartof><rights>Copyright © 2016 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4208-862484b521c4f56396529b88e96a5e02e8be2116ecd8101833a379bf8c7386d73</citedby><cites>FETCH-LOGICAL-c4208-862484b521c4f56396529b88e96a5e02e8be2116ecd8101833a379bf8c7386d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhup.2518$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhup.2518$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26948428$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Palazzo, Maria Carlotta</creatorcontrib><creatorcontrib>Arici, Chiara</creatorcontrib><creatorcontrib>Dell'Osso, Bernardo</creatorcontrib><creatorcontrib>Cremaschi, Laura</creatorcontrib><creatorcontrib>Grancini, Benedetta</creatorcontrib><creatorcontrib>Camuri, Giulia</creatorcontrib><creatorcontrib>Benatti, Beatrice</creatorcontrib><creatorcontrib>Oldani, Lucio</creatorcontrib><creatorcontrib>Dobrea, Cristina</creatorcontrib><creatorcontrib>Cattaneo, Alma</creatorcontrib><creatorcontrib>Altamura, Alfredo Carlo</creatorcontrib><title>Access and latency to first antipsychotic treatment in Italian patients with schizophrenia and other schizophrenic spectrum disorders across different epochs</title><title>Human psychopharmacology</title><addtitle>Hum. Psychopharmacol Clin Exp</addtitle><description><![CDATA[Background
The duration of untreated illness (DUI) is a measure to express the latency to first psychopharmacological treatment: it differs among psychiatric disorders, being influenced by several illness‐intrinsic and environmental factors. The present study aimed to assess differences in DUI and related variables in patients with schizophrenia (SKZ) versus other schizophrenic spectrum disorders (SSDs) across different epochs.
Methods
101 SKZ or SSD patients were assessed with respect to DUI and related variables through clinical interview and questionnaire.
Results
Patients with SKZ showed earlier ages of onset, first diagnosis and first antipsychotic treatment compared with patients with other SSDs (F = 11.02, p < 0.001; F = 12.68, p < 0.001; F = 13.74, p < 0.001, respectively) who showed an earlier access to benzodiazepines than SKZ patients (F = 6.547; p < 0.05). Dividing the total sample by the epoch of onset (before 1978; between 1978–2000; after 2000) showed a significantly later age of onset in patients with onset within the two most recent epochs (F = 7.46; p < 0.001) and a reduced DUI across epochs (from 144 to 41 to 20 months, on average; F = 11.78, p < 0.001).
Conclusion
Schizophrenic patients showed earlier onset and longer DUI compared with patients with other SSDs. Data on the total sample showed a later age of onset and a reduced DUI across epochs. Copyright © 2016 John Wiley & Sons, Ltd.]]></description><subject>Adult</subject><subject>Age of Onset</subject><subject>duration of untreated illness (DUI)</subject><subject>epochs of onset</subject><subject>Female</subject><subject>Humans</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Psychotic Disorders - drug therapy</subject><subject>Psychotic Disorders - epidemiology</subject><subject>schizophrenia (SKZ)</subject><subject>Schizophrenia - drug therapy</subject><subject>Schizophrenia - epidemiology</subject><subject>schizophrenic spectrum disorders (SSDs)</subject><subject>Time Factors</subject><subject>Time-to-Treatment - trends</subject><issn>0885-6222</issn><issn>1099-1077</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdtqFTEUhoModrcKPoEEvPFmak6Tw2UptS0tKmLpZchk1jCps2fGJEPdvkvf1ex2W6ggeBX48_GtrPwIvaHkkBLCPvTLfMhqqp-hFSXGVJQo9RytiNZ1JRlje2g_pRtCyh0xL9Eek0ZowfQK3R15DylhN7Z4cBlGv8F5wl2IKZcwhzltfD_l4HGO4PIaxozDiM-zG4Ib8exyKFHCtyH3OPk-_JrmPsIY3L1zyj3EJ7nHaQaf47LGbUhTbCGW8T5O5RVt6DqI2xEwT75Pr9CLzg0JXu_OA3T18eTb8Vl1-fn0_PjosvKCEV1pyco6Tc2oF10tuZE1M43WYKSrgTDQDTBKJfhWU0I1544r03TaK65lq_gBev_gneP0Y4GU7TokD8PgRpiWZKlSUgpBlPgflAqhWc0L-u4v9GZa4lgW2VJEGf1EeP8FETo7x7B2cWMpsdt2bWnXbtst6NudcGnW0D6Cf-osQPUA3IYBNv8U2bOrLzvhjg8pw89H3sXvViquanv96dQaysnXi-sLK_hvzXS_Sg</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Palazzo, Maria Carlotta</creator><creator>Arici, Chiara</creator><creator>Dell'Osso, Bernardo</creator><creator>Cremaschi, Laura</creator><creator>Grancini, Benedetta</creator><creator>Camuri, Giulia</creator><creator>Benatti, Beatrice</creator><creator>Oldani, Lucio</creator><creator>Dobrea, Cristina</creator><creator>Cattaneo, Alma</creator><creator>Altamura, Alfredo Carlo</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>Access and latency to first antipsychotic treatment in Italian patients with schizophrenia and other schizophrenic spectrum disorders across different epochs</title><author>Palazzo, Maria Carlotta ; Arici, Chiara ; Dell'Osso, Bernardo ; Cremaschi, Laura ; Grancini, Benedetta ; Camuri, Giulia ; Benatti, Beatrice ; Oldani, Lucio ; Dobrea, Cristina ; Cattaneo, Alma ; Altamura, Alfredo Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4208-862484b521c4f56396529b88e96a5e02e8be2116ecd8101833a379bf8c7386d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>duration of untreated illness (DUI)</topic><topic>epochs of onset</topic><topic>Female</topic><topic>Humans</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Psychotic Disorders - drug therapy</topic><topic>Psychotic Disorders - epidemiology</topic><topic>schizophrenia (SKZ)</topic><topic>Schizophrenia - drug therapy</topic><topic>Schizophrenia - epidemiology</topic><topic>schizophrenic spectrum disorders (SSDs)</topic><topic>Time Factors</topic><topic>Time-to-Treatment - trends</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Palazzo, Maria Carlotta</creatorcontrib><creatorcontrib>Arici, Chiara</creatorcontrib><creatorcontrib>Dell'Osso, Bernardo</creatorcontrib><creatorcontrib>Cremaschi, Laura</creatorcontrib><creatorcontrib>Grancini, Benedetta</creatorcontrib><creatorcontrib>Camuri, Giulia</creatorcontrib><creatorcontrib>Benatti, Beatrice</creatorcontrib><creatorcontrib>Oldani, Lucio</creatorcontrib><creatorcontrib>Dobrea, Cristina</creatorcontrib><creatorcontrib>Cattaneo, Alma</creatorcontrib><creatorcontrib>Altamura, Alfredo Carlo</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Human psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Palazzo, Maria Carlotta</au><au>Arici, Chiara</au><au>Dell'Osso, Bernardo</au><au>Cremaschi, Laura</au><au>Grancini, Benedetta</au><au>Camuri, Giulia</au><au>Benatti, Beatrice</au><au>Oldani, Lucio</au><au>Dobrea, Cristina</au><au>Cattaneo, Alma</au><au>Altamura, Alfredo Carlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Access and latency to first antipsychotic treatment in Italian patients with schizophrenia and other schizophrenic spectrum disorders across different epochs</atitle><jtitle>Human psychopharmacology</jtitle><addtitle>Hum. Psychopharmacol Clin Exp</addtitle><date>2016-03</date><risdate>2016</risdate><volume>31</volume><issue>2</issue><spage>113</spage><epage>120</epage><pages>113-120</pages><issn>0885-6222</issn><eissn>1099-1077</eissn><coden>HUPSEC</coden><abstract><![CDATA[Background
The duration of untreated illness (DUI) is a measure to express the latency to first psychopharmacological treatment: it differs among psychiatric disorders, being influenced by several illness‐intrinsic and environmental factors. The present study aimed to assess differences in DUI and related variables in patients with schizophrenia (SKZ) versus other schizophrenic spectrum disorders (SSDs) across different epochs.
Methods
101 SKZ or SSD patients were assessed with respect to DUI and related variables through clinical interview and questionnaire.
Results
Patients with SKZ showed earlier ages of onset, first diagnosis and first antipsychotic treatment compared with patients with other SSDs (F = 11.02, p < 0.001; F = 12.68, p < 0.001; F = 13.74, p < 0.001, respectively) who showed an earlier access to benzodiazepines than SKZ patients (F = 6.547; p < 0.05). Dividing the total sample by the epoch of onset (before 1978; between 1978–2000; after 2000) showed a significantly later age of onset in patients with onset within the two most recent epochs (F = 7.46; p < 0.001) and a reduced DUI across epochs (from 144 to 41 to 20 months, on average; F = 11.78, p < 0.001).
Conclusion
Schizophrenic patients showed earlier onset and longer DUI compared with patients with other SSDs. Data on the total sample showed a later age of onset and a reduced DUI across epochs. Copyright © 2016 John Wiley & Sons, Ltd.]]></abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>26948428</pmid><doi>10.1002/hup.2518</doi><tpages>8</tpages></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Age of Onset duration of untreated illness (DUI) epochs of onset Female Humans Italy - epidemiology Male Middle Aged Psychotic Disorders - drug therapy Psychotic Disorders - epidemiology schizophrenia (SKZ) Schizophrenia - drug therapy Schizophrenia - epidemiology schizophrenic spectrum disorders (SSDs) Time Factors Time-to-Treatment - trends |
| title | Access and latency to first antipsychotic treatment in Italian patients with schizophrenia and other schizophrenic spectrum disorders across different epochs |
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