Reductive Metabolism of Cr(VI) by Cysteine Leads to the Formation of Binary and Ternary Cr−DNA Adducts in the Absence of Oxidative DNA Damage

Carcinogenic chromium(VI) compounds require reduction for the induction of genotoxicity. In this work, we examined a spectrum of DNA damage produced in Cr(VI)−cysteine reactions at neutral pH. Cr(VI) reduction followed single-component kinetics and led to a significant oxidation of 2‘,7‘-dichloroflu...

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