Diethylene glycol monobutyl ether (DGBE): two- and thirteen-week oral toxicity studies in Fischer 344 rats

Standard toxicologic endpoints, supplemented by additional examinations, were studied for groups of 10 Fischer 344 rats/sex given drinking water formulated to supply 0, 50, 250, or 1000 mg diethylene glycol monobutyl ether (DGBE)/kg/day for 13 weeks. These dose levels were based upon initial investi...

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Veröffentlicht in:	Food and chemical toxicology 2005-03, Vol.43 (3), p.467-481
Hauptverfasser:	Johnson, K.A., Baker, P.C., Kan, H.L., Maurissen, J.P., Spencer, P.J., Marty, M.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism DGBE Diethylene glycol monobutyl ether Dose-Response Relationship, Drug Erythrocytes - drug effects Ethylene Glycols - toxicity Female Hematologic Tests Kidney - drug effects Kidney - pathology Liver - drug effects Liver - pathology Male Medical sciences No-Observed-Adverse-Effect Level Organ Size - drug effects Rats Rats, Inbred F344 Sex Factors Subchronic toxicity Toxicity Tests Toxicology Weight Gain - drug effects
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