Comparison of drug effects on the performance of two timing tasks in rats
Previous evidence suggests that different timing tasks are differentially sensitive to pharmacological manipulation, especially when different values for the temporal parameters are used. The present series of experiments compared the effects of physostigmine, caffeine, pentobarbital, morphine, and...
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| Veröffentlicht in: | Pharmacology, biochemistry and behavior biochemistry and behavior, 2000-10, Vol.67 (2), p.377-385 |
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| creator | Popke, E.Jon Mayorga, A.J Fogle, Charles M Paule, Merle G |
| description | Previous evidence suggests that different timing tasks are differentially sensitive to pharmacological manipulation, especially when different values for the temporal parameters are used. The present series of experiments compared the effects of physostigmine, caffeine, pentobarbital, morphine, and naloxone on the performance of a differential reinforcement of low rates with limited hold (DRL-LH) and a temporal response differentiation (TRD) task. In the DRL-LH task, rats were reinforced for responses that occurred 10–14 s from the end of the previous response. In the TRD task, rats were reinforced for responses with a duration of 10–14 s. The peak response time and peak spread of the initiation time distribution (for DRL-LH) or the response duration distribution (for TRD) were used as indices of temporal discrimination. Physostigmine, caffeine, and pentobarbital produced very similar effects on peak response time for both tasks, but the effects of morphine and naloxone were different for the two tasks. Effects on peak spread for the two tasks did not always correspond to changes in peak response time, suggesting that different processes may be measured by these two endpoints. Further, these effects were independent of changes in response rate suggesting that the effects were not due to gross disruptions in motivation or motor control. These results suggest that the effects of drugs on DRL-LH and TRD performance may differ, even when temporal parameters are identical. |
| doi_str_mv | 10.1016/S0091-3057(00)00380-4 |
| format | Article |
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The present series of experiments compared the effects of physostigmine, caffeine, pentobarbital, morphine, and naloxone on the performance of a differential reinforcement of low rates with limited hold (DRL-LH) and a temporal response differentiation (TRD) task. In the DRL-LH task, rats were reinforced for responses that occurred 10–14 s from the end of the previous response. In the TRD task, rats were reinforced for responses with a duration of 10–14 s. The peak response time and peak spread of the initiation time distribution (for DRL-LH) or the response duration distribution (for TRD) were used as indices of temporal discrimination. Physostigmine, caffeine, and pentobarbital produced very similar effects on peak response time for both tasks, but the effects of morphine and naloxone were different for the two tasks. Effects on peak spread for the two tasks did not always correspond to changes in peak response time, suggesting that different processes may be measured by these two endpoints. Further, these effects were independent of changes in response rate suggesting that the effects were not due to gross disruptions in motivation or motor control. These results suggest that the effects of drugs on DRL-LH and TRD performance may differ, even when temporal parameters are identical.</description><identifier>ISSN: 0091-3057</identifier><identifier>EISSN: 1873-5177</identifier><identifier>DOI: 10.1016/S0091-3057(00)00380-4</identifier><identifier>PMID: 11124404</identifier><identifier>CODEN: PBBHAU</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Analysis of Variance ; Animals ; Behavior ; Behavior, Animal - drug effects ; Behavioral psychophysiology ; Biological and medical sciences ; Caffeine - pharmacology ; Central Nervous System Stimulants - pharmacology ; Cholinesterase Inhibitors - pharmacology ; Clock ; Dose-Response Relationship, Drug ; DRL ; Fundamental and applied biological sciences. Psychology ; Hypnotics and Sedatives - pharmacology ; Male ; Miscellaneous ; Morphine - pharmacology ; Naloxone - pharmacology ; Narcotic Antagonists - pharmacology ; Narcotics - pharmacology ; Operant ; Pentobarbital - pharmacology ; Perception ; Physostigmine - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. 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The present series of experiments compared the effects of physostigmine, caffeine, pentobarbital, morphine, and naloxone on the performance of a differential reinforcement of low rates with limited hold (DRL-LH) and a temporal response differentiation (TRD) task. In the DRL-LH task, rats were reinforced for responses that occurred 10–14 s from the end of the previous response. In the TRD task, rats were reinforced for responses with a duration of 10–14 s. The peak response time and peak spread of the initiation time distribution (for DRL-LH) or the response duration distribution (for TRD) were used as indices of temporal discrimination. Physostigmine, caffeine, and pentobarbital produced very similar effects on peak response time for both tasks, but the effects of morphine and naloxone were different for the two tasks. Effects on peak spread for the two tasks did not always correspond to changes in peak response time, suggesting that different processes may be measured by these two endpoints. Further, these effects were independent of changes in response rate suggesting that the effects were not due to gross disruptions in motivation or motor control. These results suggest that the effects of drugs on DRL-LH and TRD performance may differ, even when temporal parameters are identical.</description><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Caffeine - pharmacology</subject><subject>Central Nervous System Stimulants - pharmacology</subject><subject>Cholinesterase Inhibitors - pharmacology</subject><subject>Clock</subject><subject>Dose-Response Relationship, Drug</subject><subject>DRL</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypnotics and Sedatives - pharmacology</subject><subject>Male</subject><subject>Miscellaneous</subject><subject>Morphine - pharmacology</subject><subject>Naloxone - pharmacology</subject><subject>Narcotic Antagonists - pharmacology</subject><subject>Narcotics - pharmacology</subject><subject>Operant</subject><subject>Pentobarbital - pharmacology</subject><subject>Perception</subject><subject>Physostigmine - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Task Performance and Analysis</subject><subject>Temporal</subject><subject>Time</subject><subject>Time Factors</subject><subject>TRD</subject><issn>0091-3057</issn><issn>1873-5177</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtrGzEURkVJaBw3P6FFECjpYtqrx4xmVqGYtDEYskiyFhrNlavGM3KkcUL-feUH7jKrC5fz3cch5DOD7wxY9eMeoGGFgFJdAXwDEDUU8gOZsFqJomRKnZDJETkj5yn9BQDJK_WRnDHGuJQgJ2Q-C_3aRJ_CQIOjXdwsKTqHdkw0t8Y_SNcYXYi9GSxukfE10NH3fljS0aSnRP1AoxnTJ3LqzCrhxaFOyeOvm4fZbbG4-z2f_VwUVnIYi6Zpma1th60T6BqroKlqwSW3vFZtrRplbCVb2ZSiE6ZEVbVgHEcjHedlqcSUfN3PXcfwvME06t4ni6uVGTBsks6vVzK_msFyD9oYUoro9Dr63sQ3zUBvHeqdQ70VpAH0zqGWOfflsGDT9tj9Tx2kZeDyAJhkzcrFrManI1eLUkKTqes9hVnGi8eok_WYJXY-Zr26C_6dQ_4B9oeMhQ</recordid><startdate>20001001</startdate><enddate>20001001</enddate><creator>Popke, E.Jon</creator><creator>Mayorga, A.J</creator><creator>Fogle, Charles M</creator><creator>Paule, Merle G</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope></search><sort><creationdate>20001001</creationdate><title>Comparison of drug effects on the performance of two timing tasks in rats</title><author>Popke, E.Jon ; Mayorga, A.J ; Fogle, Charles M ; Paule, Merle G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-99b1c8cdebf3ef9c709683242c287b8797ac64b4953d3a5e76b0af2ea4f225573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Behavior</topic><topic>Behavior, Animal - drug effects</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Caffeine - pharmacology</topic><topic>Central Nervous System Stimulants - pharmacology</topic><topic>Cholinesterase Inhibitors - pharmacology</topic><topic>Clock</topic><topic>Dose-Response Relationship, Drug</topic><topic>DRL</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypnotics and Sedatives - pharmacology</topic><topic>Male</topic><topic>Miscellaneous</topic><topic>Morphine - pharmacology</topic><topic>Naloxone - pharmacology</topic><topic>Narcotic Antagonists - pharmacology</topic><topic>Narcotics - pharmacology</topic><topic>Operant</topic><topic>Pentobarbital - pharmacology</topic><topic>Perception</topic><topic>Physostigmine - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Task Performance and Analysis</topic><topic>Temporal</topic><topic>Time</topic><topic>Time Factors</topic><topic>TRD</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Popke, E.Jon</creatorcontrib><creatorcontrib>Mayorga, A.J</creatorcontrib><creatorcontrib>Fogle, Charles M</creatorcontrib><creatorcontrib>Paule, Merle G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><jtitle>Pharmacology, biochemistry and behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Popke, E.Jon</au><au>Mayorga, A.J</au><au>Fogle, Charles M</au><au>Paule, Merle G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of drug effects on the performance of two timing tasks in rats</atitle><jtitle>Pharmacology, biochemistry and behavior</jtitle><addtitle>Pharmacol Biochem Behav</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>67</volume><issue>2</issue><spage>377</spage><epage>385</epage><pages>377-385</pages><issn>0091-3057</issn><eissn>1873-5177</eissn><coden>PBBHAU</coden><abstract>Previous evidence suggests that different timing tasks are differentially sensitive to pharmacological manipulation, especially when different values for the temporal parameters are used. The present series of experiments compared the effects of physostigmine, caffeine, pentobarbital, morphine, and naloxone on the performance of a differential reinforcement of low rates with limited hold (DRL-LH) and a temporal response differentiation (TRD) task. In the DRL-LH task, rats were reinforced for responses that occurred 10–14 s from the end of the previous response. In the TRD task, rats were reinforced for responses with a duration of 10–14 s. The peak response time and peak spread of the initiation time distribution (for DRL-LH) or the response duration distribution (for TRD) were used as indices of temporal discrimination. Physostigmine, caffeine, and pentobarbital produced very similar effects on peak response time for both tasks, but the effects of morphine and naloxone were different for the two tasks. Effects on peak spread for the two tasks did not always correspond to changes in peak response time, suggesting that different processes may be measured by these two endpoints. Further, these effects were independent of changes in response rate suggesting that the effects were not due to gross disruptions in motivation or motor control. These results suggest that the effects of drugs on DRL-LH and TRD performance may differ, even when temporal parameters are identical.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11124404</pmid><doi>10.1016/S0091-3057(00)00380-4</doi><tpages>9</tpages></addata></record> |
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| subjects | Analysis of Variance Animals Behavior Behavior, Animal - drug effects Behavioral psychophysiology Biological and medical sciences Caffeine - pharmacology Central Nervous System Stimulants - pharmacology Cholinesterase Inhibitors - pharmacology Clock Dose-Response Relationship, Drug DRL Fundamental and applied biological sciences. Psychology Hypnotics and Sedatives - pharmacology Male Miscellaneous Morphine - pharmacology Naloxone - pharmacology Narcotic Antagonists - pharmacology Narcotics - pharmacology Operant Pentobarbital - pharmacology Perception Physostigmine - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley Task Performance and Analysis Temporal Time Time Factors TRD |
| title | Comparison of drug effects on the performance of two timing tasks in rats |
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