In vitro genotoxicity of the West African anti-malarial herbal Cryptolepis sanguinolenta and its major alkaloid cryptolepine

Cryptolepine (CLP), the major alkaloid of the West African anti-malarial herbal Cryptolepis sanguinolenta (Periplocaceae) is a DNA intercalator that exhibits potent toxicity to a variety of mammalian cells in vitro. We have hypothesized that the DNA intercalating properties of cryptolepine could tri...

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Veröffentlicht in:	Toxicology (Amsterdam) 2005-03, Vol.208 (1), p.141-147
Hauptverfasser:	Ansah, Charles, Khan, Ayesha, Gooderham, Nigel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Africa Alkaloids - administration & dosage Alkaloids - toxicity Animals Antimalarials - administration & dosage Antimalarials - toxicity Biological and medical sciences Cell Line Cell Survival Cricetinae Cryptolepine Cryptolepis - toxicity Cryptolepis sanguinolenta DNA Damage Dose-Response Relationship, Drug Hprt mutation Indole Alkaloids Indoles - administration & dosage Indoles - toxicity Intercalating Agents - toxicity Medical sciences Medicine, Traditional Micronuclei Mutagenicity Tests Plant Extracts - administration & dosage Plant Extracts - toxicity Plant Roots - toxicity Quinolines - administration & dosage Quinolines - toxicity Toxicology
Online-Zugang:	Volltext
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