Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol)
Adult volunteers from two neighboring health centers were immunized with measles, mumps, rubella vaccine (MMR, Serum Institute of India Ltd.), either given by traditional injections or by an aerosol delivered to the respiratory tract. Baseline and one month post vaccination samples were taken and si...
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| Veröffentlicht in: | Vaccine 2005-01, Vol.23 (8), p.1079-1084 |
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| creator | Castro, Jorge Fernandez de Bennett, John V. Rincon, Hector Gallardo Munoz, M.T. Alvarez y Sanchez, Luis Alfonso E. Partida Santos, Jose Ignacio |
| description | Adult volunteers from two neighboring health centers were immunized with measles, mumps, rubella vaccine (MMR, Serum Institute of India Ltd.), either given by traditional injections or by an aerosol delivered to the respiratory tract. Baseline and one month post vaccination samples were taken and simultaneously assayed for all three antigens. Subjects were followed-up for temporally associated events after vaccination. The aerosol route was superior for measles, mumps and rubella when baseline titers were controlled for in multivariate analysis. Frequencies of post-vaccination events did not differ with statistical significance between the groups. Further evaluation of the aerosol route for MMR immunization appears warranted. |
| doi_str_mv | 10.1016/j.vaccine.2004.08.018 |
| format | Article |
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Alvarez y ; Sanchez, Luis Alfonso E. Partida ; Santos, Jose Ignacio</creator><creatorcontrib>Castro, Jorge Fernandez de ; Bennett, John V. ; Rincon, Hector Gallardo ; Munoz, M.T. Alvarez y ; Sanchez, Luis Alfonso E. Partida ; Santos, Jose Ignacio</creatorcontrib><description>Adult volunteers from two neighboring health centers were immunized with measles, mumps, rubella vaccine (MMR, Serum Institute of India Ltd.), either given by traditional injections or by an aerosol delivered to the respiratory tract. Baseline and one month post vaccination samples were taken and simultaneously assayed for all three antigens. Subjects were followed-up for temporally associated events after vaccination. The aerosol route was superior for measles, mumps and rubella when baseline titers were controlled for in multivariate analysis. Frequencies of post-vaccination events did not differ with statistical significance between the groups. Further evaluation of the aerosol route for MMR immunization appears warranted.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/j.vaccine.2004.08.018</identifier><identifier>PMID: 15620482</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Administration, Inhalation ; Adolescent ; Adult ; Aerosol ; Aerosols ; Applied microbiology ; Biological and medical sciences ; Female ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Health facilities ; Health services ; Humans ; Immunization ; Immunogenicity ; Injections, Subcutaneous ; Laboratories ; Male ; Measles ; Measles-Mumps-Rubella Vaccine - administration & dosage ; Measles-Mumps-Rubella Vaccine - adverse effects ; Measles-Mumps-Rubella Vaccine - immunology ; Microbiology ; Middle Aged ; MMR Vaccine ; Multivariate Analysis ; Mumps ; Respiratory tract ; Rhinitis - chemically induced ; Rhinitis - immunology ; Sleep Stages - drug effects ; Sleep Stages - immunology ; Vaccination ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><ispartof>Vaccine, 2005-01, Vol.23 (8), p.1079-1084</ispartof><rights>2004 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jan 11, 2005</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-e5a9fd70d37eb4bd101a2b5e379aabe49092cffe5fdfd16153b5f0eb13822ba13</citedby><cites>FETCH-LOGICAL-c452t-e5a9fd70d37eb4bd101a2b5e379aabe49092cffe5fdfd16153b5f0eb13822ba13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1559065687?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16437305$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15620482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Castro, Jorge Fernandez de</creatorcontrib><creatorcontrib>Bennett, John V.</creatorcontrib><creatorcontrib>Rincon, Hector Gallardo</creatorcontrib><creatorcontrib>Munoz, M.T. Alvarez y</creatorcontrib><creatorcontrib>Sanchez, Luis Alfonso E. Partida</creatorcontrib><creatorcontrib>Santos, Jose Ignacio</creatorcontrib><title>Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol)</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Adult volunteers from two neighboring health centers were immunized with measles, mumps, rubella vaccine (MMR, Serum Institute of India Ltd.), either given by traditional injections or by an aerosol delivered to the respiratory tract. Baseline and one month post vaccination samples were taken and simultaneously assayed for all three antigens. Subjects were followed-up for temporally associated events after vaccination. The aerosol route was superior for measles, mumps and rubella when baseline titers were controlled for in multivariate analysis. Frequencies of post-vaccination events did not differ with statistical significance between the groups. Further evaluation of the aerosol route for MMR immunization appears warranted.</description><subject>Administration, Inhalation</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aerosol</subject><subject>Aerosols</subject><subject>Applied microbiology</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health facilities</subject><subject>Health services</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunogenicity</subject><subject>Injections, Subcutaneous</subject><subject>Laboratories</subject><subject>Male</subject><subject>Measles</subject><subject>Measles-Mumps-Rubella Vaccine - administration & dosage</subject><subject>Measles-Mumps-Rubella Vaccine - adverse effects</subject><subject>Measles-Mumps-Rubella Vaccine - immunology</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>MMR Vaccine</subject><subject>Multivariate Analysis</subject><subject>Mumps</subject><subject>Respiratory tract</subject><subject>Rhinitis - chemically induced</subject><subject>Rhinitis - immunology</subject><subject>Sleep Stages - drug effects</subject><subject>Sleep Stages - immunology</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkcuKFDEYhYMoTtv6CEpAlBmwyiRVqYsbkWG8wAyCKLgLufw1pKlKepJUSb-GT2zaLhhw4yqb7z-cnA-h55SUlNDm7a5cpNbWQckIqUvSlYR2D9CGdm1VME67h2hDWFMXNSU_z9CTGHeEEF7R_jE6o7xhpO7YBv2-WuQ4y2S9w37Adppm52_BWW3TAUtncLQGMAwD6BSPSAp2PwJebJAjXjvg85ubbxfYOizNPKb4Bt_aBRxWB5x-eRz8nCC-w3FWek7SgZ_j3-wAcZ9zkg8HfC4h-OjHi6fo0SDHCM_Wd4t-fLz6fvm5uP766cvlh-tC15ylArjsB9MSU7WgamXyKpIpDlXbS6mg7knPdK7NBzMY2lBeKT4QULTqGFOSVlv0-pS7D_5uhpjEZKOGcTwVFLRtm6omfQZf_gPu_Bxc7iYo5z1peJNH3yJ-onT-RgwwiH2wkwwHQYk4KhM7sc4ljsoE6URWlu9erOmzmsDcX62OMvBqBWTUchyCdNrGe66pq7bKZrfo_YmDPNpiIYioLTgNxoYsTxhv_1PlD-cluXw</recordid><startdate>20050111</startdate><enddate>20050111</enddate><creator>Castro, Jorge Fernandez de</creator><creator>Bennett, John V.</creator><creator>Rincon, Hector Gallardo</creator><creator>Munoz, M.T. 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Alvarez y</au><au>Sanchez, Luis Alfonso E. Partida</au><au>Santos, Jose Ignacio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol)</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2005-01-11</date><risdate>2005</risdate><volume>23</volume><issue>8</issue><spage>1079</spage><epage>1084</epage><pages>1079-1084</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>Adult volunteers from two neighboring health centers were immunized with measles, mumps, rubella vaccine (MMR, Serum Institute of India Ltd.), either given by traditional injections or by an aerosol delivered to the respiratory tract. Baseline and one month post vaccination samples were taken and simultaneously assayed for all three antigens. Subjects were followed-up for temporally associated events after vaccination. The aerosol route was superior for measles, mumps and rubella when baseline titers were controlled for in multivariate analysis. Frequencies of post-vaccination events did not differ with statistical significance between the groups. Further evaluation of the aerosol route for MMR immunization appears warranted.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>15620482</pmid><doi>10.1016/j.vaccine.2004.08.018</doi><tpages>6</tpages></addata></record> |
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| ispartof | Vaccine, 2005-01, Vol.23 (8), p.1079-1084 |
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| language | eng |
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| subjects | Administration, Inhalation Adolescent Adult Aerosol Aerosols Applied microbiology Biological and medical sciences Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Health facilities Health services Humans Immunization Immunogenicity Injections, Subcutaneous Laboratories Male Measles Measles-Mumps-Rubella Vaccine - administration & dosage Measles-Mumps-Rubella Vaccine - adverse effects Measles-Mumps-Rubella Vaccine - immunology Microbiology Middle Aged MMR Vaccine Multivariate Analysis Mumps Respiratory tract Rhinitis - chemically induced Rhinitis - immunology Sleep Stages - drug effects Sleep Stages - immunology Vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) |
| title | Evaluation of immunogenicity and side effects of triple viral vaccine (MMR) in adults, given by two routes: subcutaneous and respiratory (aerosol) |
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