Protein oxidative damage in arsenic induced rat brain: influence of dl-α-lipoic acid

A body of evidence has accumulated implicating free radical generation and reaction of arsenic with protein thiols in the biochemical and molecular mechanisms of arsenic toxicity. Brain readily undergoes oxidative damage, so it is important to determine whether arsenic-induced changes in rat brain m...

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Veröffentlicht in:	Toxicology letters 2005-01, Vol.155 (1), p.27-34
Hauptverfasser:	Samuel, Shila, Kathirvel, Ramanathan, Jayavelu, Tamilselvan, Chinnakkannu, Panneerselvam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - pharmacology Arsenic Arsenic - toxicity Biological and medical sciences Brain Chemistry - drug effects Brain regions Chemical and industrial products toxicology. Toxic occupational diseases dl-α-Lipoic acid Male Medical sciences Membrane Proteins - metabolism Metals and various inorganic compounds Nerve Tissue Proteins - drug effects Oxidation-Reduction Oxidative stress Protein Binding Proteins Rats Rats, Wistar Sulfhydryl Compounds - metabolism Thioctic Acid - pharmacology Toxicology
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