Protein oxidative damage in arsenic induced rat brain: influence of dl-α-lipoic acid
A body of evidence has accumulated implicating free radical generation and reaction of arsenic with protein thiols in the biochemical and molecular mechanisms of arsenic toxicity. Brain readily undergoes oxidative damage, so it is important to determine whether arsenic-induced changes in rat brain m...
Gespeichert in:
| Veröffentlicht in: | Toxicology letters 2005-01, Vol.155 (1), p.27-34 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 34 |
|---|---|
| container_issue | 1 |
| container_start_page | 27 |
| container_title | Toxicology letters |
| container_volume | 155 |
| creator | Samuel, Shila Kathirvel, Ramanathan Jayavelu, Tamilselvan Chinnakkannu, Panneerselvam |
| description | A body of evidence has accumulated implicating free radical generation and reaction of arsenic with protein thiols in the biochemical and molecular mechanisms of arsenic toxicity. Brain readily undergoes oxidative damage, so it is important to determine whether arsenic-induced changes in rat brain may be associated with oxidative events. An increase in oxidative stress may contribute to the development of protein damage in rat brain. Present experiments were performed to study the effect of arsenic (sodium arsenite, 100
ppm mixed in drinking water) on protein oxidation and further to demonstrate the potential of
dl-α-lipoic acid (70
mg/kg body weight) against arsenic-induced changes in different anatomic regions (cortex, striatum, cerebellum, hypothalamus and hippocampus) of the brain of male
Wistar rats. We report here that arsenic treated rats had a significantly higher level of oxidised protein as assessed by increased carbonyl residues and decreased protein thiols (protein sulfhydryls) as compared to control rats in all five regions studied, with the most notable changes occurring in the cortex, striatum and hippocampus. Coadministration of lipoic acid along with arsenic resulted in reversal of the arsenic induced trends in carbonyl and sulfhydryl concentrations. The results of the study showed, lipoic acid treatment reduces oxidative protein damage in arsenic intoxicated rat brain regions, which is associated with its antioxidant activity that combines free radical scavenging and metal chelating properties. |
| doi_str_mv | 10.1016/j.toxlet.2004.08.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_17763050</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0378427404003972</els_id><sourcerecordid>17763050</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-ee2bc4b8978847729d8e73528eb1494df61f2fa85b8b0cfbe5447664a06523c3</originalsourceid><addsrcrecordid>eNp9kMtq3DAUhkVpaSZp36AEb5qd3SNbN2cRKCE3CDSLdC1k6aho8FgTyQ7pY_VF8kzVMAPZZXUOh-__OXyEfKPQUKDix7qZ48uIc9MCsAZUA0A_kBVVsq87KvqPZAWdVDVrJTsixzmvAUAwwT-TI8q54h0XK_L7IcUZw1TFl-DMHJ6xcmZj_mBVbiZlnIItq1ssuiqZuRqSCdN5OflxwcliFX3lxvr1Xz2GbSywscF9IZ-8GTN-PcwT8nh99Xh5W9__urm7_HlfW9bSuUZsB8sG1UulmJRt7xTKjrcKB8p65rygvvVG8UENYP2AnDEpBDMgeNvZ7oSc7Wu3KT4tmGe9CdniOJoJ45I1lVJ0wKGAbA_aFHNO6PU2hY1JfzUFvbOp13pvU-9salC62Cyx00P_MmzQvYUO-grw_QCYbM3ok5lsyG-cYFSAZIW72HNYZDwHTDrbsLPnQkI7axfD-5_8B2fclVA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17763050</pqid></control><display><type>article</type><title>Protein oxidative damage in arsenic induced rat brain: influence of dl-α-lipoic acid</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Samuel, Shila ; Kathirvel, Ramanathan ; Jayavelu, Tamilselvan ; Chinnakkannu, Panneerselvam</creator><creatorcontrib>Samuel, Shila ; Kathirvel, Ramanathan ; Jayavelu, Tamilselvan ; Chinnakkannu, Panneerselvam</creatorcontrib><description>A body of evidence has accumulated implicating free radical generation and reaction of arsenic with protein thiols in the biochemical and molecular mechanisms of arsenic toxicity. Brain readily undergoes oxidative damage, so it is important to determine whether arsenic-induced changes in rat brain may be associated with oxidative events. An increase in oxidative stress may contribute to the development of protein damage in rat brain. Present experiments were performed to study the effect of arsenic (sodium arsenite, 100
ppm mixed in drinking water) on protein oxidation and further to demonstrate the potential of
dl-α-lipoic acid (70
mg/kg body weight) against arsenic-induced changes in different anatomic regions (cortex, striatum, cerebellum, hypothalamus and hippocampus) of the brain of male
Wistar rats. We report here that arsenic treated rats had a significantly higher level of oxidised protein as assessed by increased carbonyl residues and decreased protein thiols (protein sulfhydryls) as compared to control rats in all five regions studied, with the most notable changes occurring in the cortex, striatum and hippocampus. Coadministration of lipoic acid along with arsenic resulted in reversal of the arsenic induced trends in carbonyl and sulfhydryl concentrations. The results of the study showed, lipoic acid treatment reduces oxidative protein damage in arsenic intoxicated rat brain regions, which is associated with its antioxidant activity that combines free radical scavenging and metal chelating properties.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/j.toxlet.2004.08.001</identifier><identifier>PMID: 15585356</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Antioxidants - pharmacology ; Arsenic ; Arsenic - toxicity ; Biological and medical sciences ; Brain Chemistry - drug effects ; Brain regions ; Chemical and industrial products toxicology. Toxic occupational diseases ; dl-α-Lipoic acid ; Male ; Medical sciences ; Membrane Proteins - metabolism ; Metals and various inorganic compounds ; Nerve Tissue Proteins - drug effects ; Oxidation-Reduction ; Oxidative stress ; Protein Binding ; Proteins ; Rats ; Rats, Wistar ; Sulfhydryl Compounds - metabolism ; Thioctic Acid - pharmacology ; Toxicology</subject><ispartof>Toxicology letters, 2005-01, Vol.155 (1), p.27-34</ispartof><rights>2004 Elsevier Ireland Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-ee2bc4b8978847729d8e73528eb1494df61f2fa85b8b0cfbe5447664a06523c3</citedby><cites>FETCH-LOGICAL-c421t-ee2bc4b8978847729d8e73528eb1494df61f2fa85b8b0cfbe5447664a06523c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.toxlet.2004.08.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16416074$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15585356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Samuel, Shila</creatorcontrib><creatorcontrib>Kathirvel, Ramanathan</creatorcontrib><creatorcontrib>Jayavelu, Tamilselvan</creatorcontrib><creatorcontrib>Chinnakkannu, Panneerselvam</creatorcontrib><title>Protein oxidative damage in arsenic induced rat brain: influence of dl-α-lipoic acid</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>A body of evidence has accumulated implicating free radical generation and reaction of arsenic with protein thiols in the biochemical and molecular mechanisms of arsenic toxicity. Brain readily undergoes oxidative damage, so it is important to determine whether arsenic-induced changes in rat brain may be associated with oxidative events. An increase in oxidative stress may contribute to the development of protein damage in rat brain. Present experiments were performed to study the effect of arsenic (sodium arsenite, 100
ppm mixed in drinking water) on protein oxidation and further to demonstrate the potential of
dl-α-lipoic acid (70
mg/kg body weight) against arsenic-induced changes in different anatomic regions (cortex, striatum, cerebellum, hypothalamus and hippocampus) of the brain of male
Wistar rats. We report here that arsenic treated rats had a significantly higher level of oxidised protein as assessed by increased carbonyl residues and decreased protein thiols (protein sulfhydryls) as compared to control rats in all five regions studied, with the most notable changes occurring in the cortex, striatum and hippocampus. Coadministration of lipoic acid along with arsenic resulted in reversal of the arsenic induced trends in carbonyl and sulfhydryl concentrations. The results of the study showed, lipoic acid treatment reduces oxidative protein damage in arsenic intoxicated rat brain regions, which is associated with its antioxidant activity that combines free radical scavenging and metal chelating properties.</description><subject>Animals</subject><subject>Antioxidants - pharmacology</subject><subject>Arsenic</subject><subject>Arsenic - toxicity</subject><subject>Biological and medical sciences</subject><subject>Brain Chemistry - drug effects</subject><subject>Brain regions</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>dl-α-Lipoic acid</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane Proteins - metabolism</subject><subject>Metals and various inorganic compounds</subject><subject>Nerve Tissue Proteins - drug effects</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Protein Binding</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Sulfhydryl Compounds - metabolism</subject><subject>Thioctic Acid - pharmacology</subject><subject>Toxicology</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtq3DAUhkVpaSZp36AEb5qd3SNbN2cRKCE3CDSLdC1k6aho8FgTyQ7pY_VF8kzVMAPZZXUOh-__OXyEfKPQUKDix7qZ48uIc9MCsAZUA0A_kBVVsq87KvqPZAWdVDVrJTsixzmvAUAwwT-TI8q54h0XK_L7IcUZw1TFl-DMHJ6xcmZj_mBVbiZlnIItq1ssuiqZuRqSCdN5OflxwcliFX3lxvr1Xz2GbSywscF9IZ-8GTN-PcwT8nh99Xh5W9__urm7_HlfW9bSuUZsB8sG1UulmJRt7xTKjrcKB8p65rygvvVG8UENYP2AnDEpBDMgeNvZ7oSc7Wu3KT4tmGe9CdniOJoJ45I1lVJ0wKGAbA_aFHNO6PU2hY1JfzUFvbOp13pvU-9salC62Cyx00P_MmzQvYUO-grw_QCYbM3ok5lsyG-cYFSAZIW72HNYZDwHTDrbsLPnQkI7axfD-5_8B2fclVA</recordid><startdate>20050115</startdate><enddate>20050115</enddate><creator>Samuel, Shila</creator><creator>Kathirvel, Ramanathan</creator><creator>Jayavelu, Tamilselvan</creator><creator>Chinnakkannu, Panneerselvam</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>20050115</creationdate><title>Protein oxidative damage in arsenic induced rat brain: influence of dl-α-lipoic acid</title><author>Samuel, Shila ; Kathirvel, Ramanathan ; Jayavelu, Tamilselvan ; Chinnakkannu, Panneerselvam</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-ee2bc4b8978847729d8e73528eb1494df61f2fa85b8b0cfbe5447664a06523c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>Animals</topic><topic>Antioxidants - pharmacology</topic><topic>Arsenic</topic><topic>Arsenic - toxicity</topic><topic>Biological and medical sciences</topic><topic>Brain Chemistry - drug effects</topic><topic>Brain regions</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>dl-α-Lipoic acid</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane Proteins - metabolism</topic><topic>Metals and various inorganic compounds</topic><topic>Nerve Tissue Proteins - drug effects</topic><topic>Oxidation-Reduction</topic><topic>Oxidative stress</topic><topic>Protein Binding</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Sulfhydryl Compounds - metabolism</topic><topic>Thioctic Acid - pharmacology</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Samuel, Shila</creatorcontrib><creatorcontrib>Kathirvel, Ramanathan</creatorcontrib><creatorcontrib>Jayavelu, Tamilselvan</creatorcontrib><creatorcontrib>Chinnakkannu, Panneerselvam</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Samuel, Shila</au><au>Kathirvel, Ramanathan</au><au>Jayavelu, Tamilselvan</au><au>Chinnakkannu, Panneerselvam</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein oxidative damage in arsenic induced rat brain: influence of dl-α-lipoic acid</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>2005-01-15</date><risdate>2005</risdate><volume>155</volume><issue>1</issue><spage>27</spage><epage>34</epage><pages>27-34</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>A body of evidence has accumulated implicating free radical generation and reaction of arsenic with protein thiols in the biochemical and molecular mechanisms of arsenic toxicity. Brain readily undergoes oxidative damage, so it is important to determine whether arsenic-induced changes in rat brain may be associated with oxidative events. An increase in oxidative stress may contribute to the development of protein damage in rat brain. Present experiments were performed to study the effect of arsenic (sodium arsenite, 100
ppm mixed in drinking water) on protein oxidation and further to demonstrate the potential of
dl-α-lipoic acid (70
mg/kg body weight) against arsenic-induced changes in different anatomic regions (cortex, striatum, cerebellum, hypothalamus and hippocampus) of the brain of male
Wistar rats. We report here that arsenic treated rats had a significantly higher level of oxidised protein as assessed by increased carbonyl residues and decreased protein thiols (protein sulfhydryls) as compared to control rats in all five regions studied, with the most notable changes occurring in the cortex, striatum and hippocampus. Coadministration of lipoic acid along with arsenic resulted in reversal of the arsenic induced trends in carbonyl and sulfhydryl concentrations. The results of the study showed, lipoic acid treatment reduces oxidative protein damage in arsenic intoxicated rat brain regions, which is associated with its antioxidant activity that combines free radical scavenging and metal chelating properties.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>15585356</pmid><doi>10.1016/j.toxlet.2004.08.001</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 2005-01, Vol.155 (1), p.27-34 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_17763050 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Antioxidants - pharmacology Arsenic Arsenic - toxicity Biological and medical sciences Brain Chemistry - drug effects Brain regions Chemical and industrial products toxicology. Toxic occupational diseases dl-α-Lipoic acid Male Medical sciences Membrane Proteins - metabolism Metals and various inorganic compounds Nerve Tissue Proteins - drug effects Oxidation-Reduction Oxidative stress Protein Binding Proteins Rats Rats, Wistar Sulfhydryl Compounds - metabolism Thioctic Acid - pharmacology Toxicology |
| title | Protein oxidative damage in arsenic induced rat brain: influence of dl-α-lipoic acid |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T16%3A11%3A12IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protein%20oxidative%20damage%20in%20arsenic%20induced%20rat%20brain:%20influence%20of%20dl-%CE%B1-lipoic%20acid&rft.jtitle=Toxicology%20letters&rft.au=Samuel,%20Shila&rft.date=2005-01-15&rft.volume=155&rft.issue=1&rft.spage=27&rft.epage=34&rft.pages=27-34&rft.issn=0378-4274&rft.eissn=1879-3169&rft.coden=TOLED5&rft_id=info:doi/10.1016/j.toxlet.2004.08.001&rft_dat=%3Cproquest_cross%3E17763050%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17763050&rft_id=info:pmid/15585356&rft_els_id=S0378427404003972&rfr_iscdi=true |