Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort
Objective To determine, first, if fat mass index (FMI) or fat‐free mass index (FFMI) and serum adipokines tumor necrosis factor (TNF) and interleukin‐6 (IL‐6) are associated with prevalent (stage 2) foot pain, and, second, if they are predictive of future (stage 3) foot pain. Methods A subset of par...
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| Veröffentlicht in: | Arthritis care & research (2010) 2016-04, Vol.68 (4), p.526-533 |
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| creator | Walsh, Tom P. Gill, Tiffany K. Evans, Angela M. Yaxley, Alison Shanahan, E. Michael Hill, Catherine L. |
| description | Objective
To determine, first, if fat mass index (FMI) or fat‐free mass index (FFMI) and serum adipokines tumor necrosis factor (TNF) and interleukin‐6 (IL‐6) are associated with prevalent (stage 2) foot pain, and, second, if they are predictive of future (stage 3) foot pain.
Methods
A subset of participants ages ≥50 years (n = 1,462) from the North West Adelaide Health Study were used for this study. Participants from this community cohort were asked in stage 2 (2004–2006) and stage 3 (2008–2010) if they had foot pain, aching, or stiffness. In stage 2, serum adipokines and anthropometry were measured, while body composition was analyzed with dual x‐ray absorptiometry. These variables, along with comorbidities and social history, were used in logistic regression analyses to determine if FMI, FFMI, and serum adipokines were associated with foot pain.
Results
Prevalent foot pain was present in 20.2% of participants, and future foot pain in 36.4%. Following multivariate modeling, the odds of having pain at stage 2 increased by 8% for each FMI unit (odds ratio [OR] 1.08, 95% confidence interval [95% CI] 1.04–1.12), while the odds of having pain at stage 3 increased by 6% for each FMI unit at stage 2 (OR 1.06, 95% CI 1.02–1.11). TNF level, IL‐6 level, and FFMI were not associated with pain.
Conclusion
Increased FMI, but not body mass index, FFMI, or TNF or IL‐6 level, was associated with both prevalent and future foot pain. These results suggest that body fat may be more important than body weight with respect to foot pain. The role played by other adipokines requires further investigation. |
| doi_str_mv | 10.1002/acr.22719 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1776094389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1776094389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3609-75fa77c278a29366c7920bdfa929c2e5991acbbc7c5b0524bb3be8a9ef3f1cfc3</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMo7rLuwT8gOeqhu_lom-ZYiquiooiit5KkCRttm7Vpkf33RrvuzWFg5vDMM_ACcIrRAiNElkJ1C0IY5gdgSnCCozhNssP9Hr9NwNz7dxSKkiyj_BhMSEpxEm6m4Db33ikreuta6AxciR7eC--haCuYV3bjPmyrPXy1_RqunOvho7AtDC1g4ZpmaG2_Ddvadf0JODKi9nq-mzPwsrp8Lq6ju4ermyK_ixRNEY9YYgRjirBMEE7TVDFOkKyM4IQrohPOsVBSKqYSiRISS0mlzgTXhhqsjKIzcD56N537HLTvy8Z6petatNoNvsSMhT8xzXhAL0ZUdc77Tpty09lGdNsSo_InvjLEV_7GF9iznXaQja725F9YAViOwJet9fZ_U5kXT6PyG9KKeF8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1776094389</pqid></control><display><type>article</type><title>Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Walsh, Tom P. ; Gill, Tiffany K. ; Evans, Angela M. ; Yaxley, Alison ; Shanahan, E. Michael ; Hill, Catherine L.</creator><creatorcontrib>Walsh, Tom P. ; Gill, Tiffany K. ; Evans, Angela M. ; Yaxley, Alison ; Shanahan, E. Michael ; Hill, Catherine L.</creatorcontrib><description>Objective
To determine, first, if fat mass index (FMI) or fat‐free mass index (FFMI) and serum adipokines tumor necrosis factor (TNF) and interleukin‐6 (IL‐6) are associated with prevalent (stage 2) foot pain, and, second, if they are predictive of future (stage 3) foot pain.
Methods
A subset of participants ages ≥50 years (n = 1,462) from the North West Adelaide Health Study were used for this study. Participants from this community cohort were asked in stage 2 (2004–2006) and stage 3 (2008–2010) if they had foot pain, aching, or stiffness. In stage 2, serum adipokines and anthropometry were measured, while body composition was analyzed with dual x‐ray absorptiometry. These variables, along with comorbidities and social history, were used in logistic regression analyses to determine if FMI, FFMI, and serum adipokines were associated with foot pain.
Results
Prevalent foot pain was present in 20.2% of participants, and future foot pain in 36.4%. Following multivariate modeling, the odds of having pain at stage 2 increased by 8% for each FMI unit (odds ratio [OR] 1.08, 95% confidence interval [95% CI] 1.04–1.12), while the odds of having pain at stage 3 increased by 6% for each FMI unit at stage 2 (OR 1.06, 95% CI 1.02–1.11). TNF level, IL‐6 level, and FFMI were not associated with pain.
Conclusion
Increased FMI, but not body mass index, FFMI, or TNF or IL‐6 level, was associated with both prevalent and future foot pain. These results suggest that body fat may be more important than body weight with respect to foot pain. The role played by other adipokines requires further investigation.</description><identifier>ISSN: 2151-464X</identifier><identifier>EISSN: 2151-4658</identifier><identifier>DOI: 10.1002/acr.22719</identifier><identifier>PMID: 26315271</identifier><language>eng</language><publisher>United States</publisher><subject>Adipokines - blood ; Adiposity ; Aged ; Aged, 80 and over ; Biomarkers - blood ; Body Mass Index ; Cohort Studies ; Comorbidity ; Cross-Sectional Studies ; Disease Progression ; Female ; Foot - innervation ; Foot Diseases - diagnosis ; Foot Diseases - epidemiology ; Foot Diseases - physiopathology ; Humans ; Interleukin-6 - blood ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Pain - diagnosis ; Pain - epidemiology ; Pain - physiopathology ; Pain Measurement ; Prevalence ; Risk Factors ; Severity of Illness Index ; South Australia - epidemiology ; Tumor Necrosis Factor-alpha - blood</subject><ispartof>Arthritis care & research (2010), 2016-04, Vol.68 (4), p.526-533</ispartof><rights>2016, American College of Rheumatology</rights><rights>2016, American College of Rheumatology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3609-75fa77c278a29366c7920bdfa929c2e5991acbbc7c5b0524bb3be8a9ef3f1cfc3</citedby><cites>FETCH-LOGICAL-c3609-75fa77c278a29366c7920bdfa929c2e5991acbbc7c5b0524bb3be8a9ef3f1cfc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Facr.22719$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Facr.22719$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26315271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Walsh, Tom P.</creatorcontrib><creatorcontrib>Gill, Tiffany K.</creatorcontrib><creatorcontrib>Evans, Angela M.</creatorcontrib><creatorcontrib>Yaxley, Alison</creatorcontrib><creatorcontrib>Shanahan, E. Michael</creatorcontrib><creatorcontrib>Hill, Catherine L.</creatorcontrib><title>Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort</title><title>Arthritis care & research (2010)</title><addtitle>Arthritis Care Res (Hoboken)</addtitle><description>Objective
To determine, first, if fat mass index (FMI) or fat‐free mass index (FFMI) and serum adipokines tumor necrosis factor (TNF) and interleukin‐6 (IL‐6) are associated with prevalent (stage 2) foot pain, and, second, if they are predictive of future (stage 3) foot pain.
Methods
A subset of participants ages ≥50 years (n = 1,462) from the North West Adelaide Health Study were used for this study. Participants from this community cohort were asked in stage 2 (2004–2006) and stage 3 (2008–2010) if they had foot pain, aching, or stiffness. In stage 2, serum adipokines and anthropometry were measured, while body composition was analyzed with dual x‐ray absorptiometry. These variables, along with comorbidities and social history, were used in logistic regression analyses to determine if FMI, FFMI, and serum adipokines were associated with foot pain.
Results
Prevalent foot pain was present in 20.2% of participants, and future foot pain in 36.4%. Following multivariate modeling, the odds of having pain at stage 2 increased by 8% for each FMI unit (odds ratio [OR] 1.08, 95% confidence interval [95% CI] 1.04–1.12), while the odds of having pain at stage 3 increased by 6% for each FMI unit at stage 2 (OR 1.06, 95% CI 1.02–1.11). TNF level, IL‐6 level, and FFMI were not associated with pain.
Conclusion
Increased FMI, but not body mass index, FFMI, or TNF or IL‐6 level, was associated with both prevalent and future foot pain. These results suggest that body fat may be more important than body weight with respect to foot pain. The role played by other adipokines requires further investigation.</description><subject>Adipokines - blood</subject><subject>Adiposity</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers - blood</subject><subject>Body Mass Index</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Cross-Sectional Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Foot - innervation</subject><subject>Foot Diseases - diagnosis</subject><subject>Foot Diseases - epidemiology</subject><subject>Foot Diseases - physiopathology</subject><subject>Humans</subject><subject>Interleukin-6 - blood</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Pain - diagnosis</subject><subject>Pain - epidemiology</subject><subject>Pain - physiopathology</subject><subject>Pain Measurement</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>South Australia - epidemiology</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><issn>2151-464X</issn><issn>2151-4658</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1LxDAQhoMo7rLuwT8gOeqhu_lom-ZYiquiooiit5KkCRttm7Vpkf33RrvuzWFg5vDMM_ACcIrRAiNElkJ1C0IY5gdgSnCCozhNssP9Hr9NwNz7dxSKkiyj_BhMSEpxEm6m4Db33ikreuta6AxciR7eC--haCuYV3bjPmyrPXy1_RqunOvho7AtDC1g4ZpmaG2_Ddvadf0JODKi9nq-mzPwsrp8Lq6ju4ermyK_ixRNEY9YYgRjirBMEE7TVDFOkKyM4IQrohPOsVBSKqYSiRISS0mlzgTXhhqsjKIzcD56N537HLTvy8Z6petatNoNvsSMhT8xzXhAL0ZUdc77Tpty09lGdNsSo_InvjLEV_7GF9iznXaQja725F9YAViOwJet9fZ_U5kXT6PyG9KKeF8</recordid><startdate>201604</startdate><enddate>201604</enddate><creator>Walsh, Tom P.</creator><creator>Gill, Tiffany K.</creator><creator>Evans, Angela M.</creator><creator>Yaxley, Alison</creator><creator>Shanahan, E. Michael</creator><creator>Hill, Catherine L.</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201604</creationdate><title>Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort</title><author>Walsh, Tom P. ; Gill, Tiffany K. ; Evans, Angela M. ; Yaxley, Alison ; Shanahan, E. Michael ; Hill, Catherine L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3609-75fa77c278a29366c7920bdfa929c2e5991acbbc7c5b0524bb3be8a9ef3f1cfc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adipokines - blood</topic><topic>Adiposity</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers - blood</topic><topic>Body Mass Index</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Cross-Sectional Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Foot - innervation</topic><topic>Foot Diseases - diagnosis</topic><topic>Foot Diseases - epidemiology</topic><topic>Foot Diseases - physiopathology</topic><topic>Humans</topic><topic>Interleukin-6 - blood</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Odds Ratio</topic><topic>Pain - diagnosis</topic><topic>Pain - epidemiology</topic><topic>Pain - physiopathology</topic><topic>Pain Measurement</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>South Australia - epidemiology</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Walsh, Tom P.</creatorcontrib><creatorcontrib>Gill, Tiffany K.</creatorcontrib><creatorcontrib>Evans, Angela M.</creatorcontrib><creatorcontrib>Yaxley, Alison</creatorcontrib><creatorcontrib>Shanahan, E. Michael</creatorcontrib><creatorcontrib>Hill, Catherine L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Arthritis care & research (2010)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Walsh, Tom P.</au><au>Gill, Tiffany K.</au><au>Evans, Angela M.</au><au>Yaxley, Alison</au><au>Shanahan, E. Michael</au><au>Hill, Catherine L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort</atitle><jtitle>Arthritis care & research (2010)</jtitle><addtitle>Arthritis Care Res (Hoboken)</addtitle><date>2016-04</date><risdate>2016</risdate><volume>68</volume><issue>4</issue><spage>526</spage><epage>533</epage><pages>526-533</pages><issn>2151-464X</issn><eissn>2151-4658</eissn><abstract>Objective
To determine, first, if fat mass index (FMI) or fat‐free mass index (FFMI) and serum adipokines tumor necrosis factor (TNF) and interleukin‐6 (IL‐6) are associated with prevalent (stage 2) foot pain, and, second, if they are predictive of future (stage 3) foot pain.
Methods
A subset of participants ages ≥50 years (n = 1,462) from the North West Adelaide Health Study were used for this study. Participants from this community cohort were asked in stage 2 (2004–2006) and stage 3 (2008–2010) if they had foot pain, aching, or stiffness. In stage 2, serum adipokines and anthropometry were measured, while body composition was analyzed with dual x‐ray absorptiometry. These variables, along with comorbidities and social history, were used in logistic regression analyses to determine if FMI, FFMI, and serum adipokines were associated with foot pain.
Results
Prevalent foot pain was present in 20.2% of participants, and future foot pain in 36.4%. Following multivariate modeling, the odds of having pain at stage 2 increased by 8% for each FMI unit (odds ratio [OR] 1.08, 95% confidence interval [95% CI] 1.04–1.12), while the odds of having pain at stage 3 increased by 6% for each FMI unit at stage 2 (OR 1.06, 95% CI 1.02–1.11). TNF level, IL‐6 level, and FFMI were not associated with pain.
Conclusion
Increased FMI, but not body mass index, FFMI, or TNF or IL‐6 level, was associated with both prevalent and future foot pain. These results suggest that body fat may be more important than body weight with respect to foot pain. The role played by other adipokines requires further investigation.</abstract><cop>United States</cop><pmid>26315271</pmid><doi>10.1002/acr.22719</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adipokines - blood Adiposity Aged Aged, 80 and over Biomarkers - blood Body Mass Index Cohort Studies Comorbidity Cross-Sectional Studies Disease Progression Female Foot - innervation Foot Diseases - diagnosis Foot Diseases - epidemiology Foot Diseases - physiopathology Humans Interleukin-6 - blood Logistic Models Male Middle Aged Multivariate Analysis Odds Ratio Pain - diagnosis Pain - epidemiology Pain - physiopathology Pain Measurement Prevalence Risk Factors Severity of Illness Index South Australia - epidemiology Tumor Necrosis Factor-alpha - blood |
| title | Association of Fat Mass and Adipokines With Foot Pain in a Community Cohort |
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