Antistaphylococcal Prenylated Acylphoroglucinol and Xanthones from Kielmeyera variabilis

Bioactivity-guided fractionation of the EtOH extract of the branches of Kielmeyera variabilis led to the isolation of a new acylphoroglucinol (1), which was active against all the MRSA strains tested herein, with pronounced activity against strain EMRSA-16. Compound 1 displayed an MIC of 0.5 mg/L as...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2016-03, Vol.79 (3), p.470-476
Hauptverfasser:	Coqueiro, Aline, Choi, Young H, Verpoorte, Robert, Gupta, Karthick B. S. S, De Mieri, Maria, Hamburger, Matthias, Young, Maria C. M, Stapleton, Paul, Gibbons, Simon, Bolzani, Vanderlan da S
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Brazil Clusiaceae - chemistry Methicillin-Resistant Staphylococcus aureus - drug effects Microbial Sensitivity Tests Molecular Structure Nuclear Magnetic Resonance, Biomolecular Phloroglucinol - analogs & derivatives Phloroglucinol - chemistry Phloroglucinol - isolation & purification Phloroglucinol - pharmacology Plant Components, Aerial - chemistry Staphylococcus aureus - drug effects Stereoisomerism Xanthones - chemistry Xanthones - isolation & purification Xanthones - pharmacology
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