MicroRNA-26b suppresses the metastasis of non-small cell lung cancer by targeting MIEN1 via NF-κB/MMP-9/VEGF pathways

MicroRNAs (miRNAs) are involved in tumor initiation and progression. MiR-26b was reported to be significantly downregulated in non-small cell lung cancer (NSCLC). However, the underlying mechanisms of miR-26b involvement in the development and progression of NSCLC remains poorly understood. In the p...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-04, Vol.472 (3), p.465-470
Hauptverfasser:	Li, Dongmei, Wei, Yucheng, Wang, Dong, Gao, Huijiang, Liu, Kui
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Carcinoma, Non-Small-Cell Lung - secondary Cell Line, Tumor Cell Movement Humans Intracellular Signaling Peptides and Proteins - metabolism Matrix Metalloproteinase 9 - metabolism Metastasis MicroRNAs - metabolism MIEN1 MiR-26b Neoplasm Invasiveness Neoplasm Proteins - metabolism NF-kappa B - metabolism NF-κB/MMP-9/VEGF pathways NSCLC Signal Transduction Vascular Endothelial Growth Factor A - metabolism
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