The protective effect of ursodeoxycholic acid in an in vitro model of the human fetal heart occurs via targeting cardiac fibroblasts

Bile acids are elevated in the blood of women with intrahepatic cholestasis of pregnancy (ICP) and this may lead to fetal arrhythmia, fetal hypoxia and potentially fetal death in utero. The bile acid taurocholic acid (TC) causes abnormal calcium dynamics and contraction in neonatal rat cardiomyocyte...

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Veröffentlicht in:	Progress in biophysics and molecular biology 2016-01, Vol.120 (1-3), p.149-163
Hauptverfasser:	Schultz, Francisca, Hasan, Alveera, Alvarez-Laviada, Anita, Miragoli, Michele, Bhogal, Navneet, Wells, Sarah, Poulet, Claire, Chambers, Jenny, Williamson, Catherine, Gorelik, Julia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn ATP-Dependent potassium channel Bile acids Calcium - metabolism Cell Hypoxia - drug effects Cell Separation Cytoprotection - drug effects Fetal arrhythmia Fetal heart Fetal Heart - cytology Fibroblasts Fibroblasts - cytology Fibroblasts - drug effects Fibroblasts - metabolism Humans Membrane Potentials - drug effects Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Rats Rats, Sprague-Dawley Taurocholic Acid - pharmacology Ursodeoxycholic acid Ursodeoxycholic Acid - pharmacology
Online-Zugang:	Volltext
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