A Histidine Residue in the Catalytic Mechanism Distinguishes Vibrio harveyi Aldehyde Dehydrogenase from Other Members of the Aldehyde Dehydrogenase Superfamily

Aldehyde dehydrogenases (ALDHs) catalyze the transfer to NAD(P) of a hydride ion from a thiohemiacetal derivative of the aldehyde coupled with a cysteine residue in the active site. In Vibrio harveyi aldehyde dehydrogenase (Vh-ALDH), a histidine residue (H450) is in proximity (3.8 Å) to the cysteine...

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Veröffentlicht in:	Biochemistry (Easton) 2000-11, Vol.39 (47), p.14409-14418
Hauptverfasser:	Zhang, Lei, Ahvazi, Bijan, Szittner, Rose, Vrielink, Alice, Meighen, Edward
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - metabolism Acylation Acyltransferases - metabolism aldehyde dehydrogenase Aldehyde Dehydrogenase - genetics Aldehyde Dehydrogenase - metabolism Animals Binding Sites - genetics Catalytic Domain - genetics Cysteine - metabolism Enzyme Activation - genetics Esterases - metabolism Ethylmaleimide - pharmacology Histidine - genetics Histidine - metabolism Kinetics Multigene Family Mutagenesis, Site-Directed NADP - metabolism Niacinamide - metabolism Rats Sequence Homology, Amino Acid Thiolester Hydrolases - metabolism Vibrio - enzymology Vibrio - genetics Vibrio harveyi
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