Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study
Background The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. The aim of this study was to clarify the role of pancreatic resection in patients 80 years of age or older. Methods A retrospective multicenter analysis of 1401 patients who had undergon...
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| Veröffentlicht in: | Journal of hepato-biliary-pancreatic sciences 2016-03, Vol.23 (3), p.188-197 |
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| container_title | Journal of hepato-biliary-pancreatic sciences |
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| creator | Sho, Masayuki Murakami, Yoshiaki Kawai, Manabu Motoi, Fuyuhiko Satoi, Sohei Matsumoto, Ippei Honda, Goro Uemura, Kenichiro Yanagimoto, Hiroaki Kurata, Masanao Akahori, Takahiro Kinoshita, Shoichi Nagai, Minako Nishiwada, Satoshi Fukumoto, Takumi Unno, Michiaki Yamaue, Hiroki Nakajima, Yoshiyuki |
| description | Background
The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. The aim of this study was to clarify the role of pancreatic resection in patients 80 years of age or older.
Methods
A retrospective multicenter analysis of 1401 patients who had undergone pancreatic resection for pancreatic cancer was performed. The patients aged ≥80 years (n = 99) were compared with a control group |
| doi_str_mv | 10.1002/jhbp.320 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1775631920</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3992513711</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4260-ecae8778c90a475a7bcad5b957c89042fc6513756daeeb60cd89d9eb692848d83</originalsourceid><addsrcrecordid>eNp1kd1qFDEUx0NR2lILfQIJeOPN1Mwkkw_vdGm3lbUW_OhlyCRn1qzzsU1maPdtfJY-mRl3XUEwNzkcfufH4X8QOsvJeU5I8Wb1vVqf04IcoONccplxJYtn-1qwI3Qa44qkR3OqKDlERwUXnArGjtH9beiXXR99xKYeIOA4hqW3psFDADO00A247gNem85ODW-xTWUCfZeag09AGl2Cw5I8_dyACREnvm8chLfY4HZs0lCiJvcwus0L9Lw2TYTT3X-Cvl5efJldZYtP8-vZu0VmWcFJBtaAFEJaRQwTpRGVNa6sVCmsVIQVteVlTkXJnQGoOLFOKqdSpQrJpJP0BL3eetehvx8hDrr10ULTmA76MepcpGGaq4Ik9NU_6KofQ5e2mygmaEqR_RXa0McYoNbr4FsTNjonerqEni6h6W_hy51wrFpwe_BP7gnItsCDb2DzX5H-cPX-divc8T4O8LjnTfihuUgp6LubuZ5R_u3z_KPQC_oLQM-irw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1774739744</pqid></control><display><type>article</type><title>Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Sho, Masayuki ; Murakami, Yoshiaki ; Kawai, Manabu ; Motoi, Fuyuhiko ; Satoi, Sohei ; Matsumoto, Ippei ; Honda, Goro ; Uemura, Kenichiro ; Yanagimoto, Hiroaki ; Kurata, Masanao ; Akahori, Takahiro ; Kinoshita, Shoichi ; Nagai, Minako ; Nishiwada, Satoshi ; Fukumoto, Takumi ; Unno, Michiaki ; Yamaue, Hiroki ; Nakajima, Yoshiyuki</creator><creatorcontrib>Sho, Masayuki ; Murakami, Yoshiaki ; Kawai, Manabu ; Motoi, Fuyuhiko ; Satoi, Sohei ; Matsumoto, Ippei ; Honda, Goro ; Uemura, Kenichiro ; Yanagimoto, Hiroaki ; Kurata, Masanao ; Akahori, Takahiro ; Kinoshita, Shoichi ; Nagai, Minako ; Nishiwada, Satoshi ; Fukumoto, Takumi ; Unno, Michiaki ; Yamaue, Hiroki ; Nakajima, Yoshiyuki</creatorcontrib><description>Background
The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. The aim of this study was to clarify the role of pancreatic resection in patients 80 years of age or older.
Methods
A retrospective multicenter analysis of 1401 patients who had undergone pancreatic resection for pancreatic cancer was performed. The patients aged ≥80 years (n = 99) were compared with a control group <80 years of age (n = 1302).
Results
There were no significant differences in the postoperative complications and mortality between the two groups. However, the prognosis of octogenarians was poorer than that of younger patients for both resectable and borderline resectable tumors. Importantly, there were few long‐term survivors in the elderly group, especially among those with borderline resectable pancreatic cancer. A multivariate analysis of the prognostic factors in the very elderly patients indicated that the completion of adjuvant chemotherapy was the only significant factor. In addition, preoperative albumin level was the only independent risk factor for a failure to complete adjuvant chemotherapy.
Conclusion
This study demonstrates that the postoperative prognosis in octogenarian patients was not good as that in younger patients possibly due to less frequent completion of adjuvant chemotherapy.
Highlight
Setting out to clarify the optimal therapeutic strategy for very elderly pancreatic cancer patients, Sho and colleagues demonstrated in this large multicenter study that the prognosis is poorer in octogenarians than in younger patients for both resectable and borderline resectable tumors, possibly due to less frequent completion of adjuvant chemotherapy.</description><identifier>ISSN: 1868-6974</identifier><identifier>EISSN: 1868-6982</identifier><identifier>DOI: 10.1002/jhbp.320</identifier><identifier>PMID: 26763744</identifier><language>eng</language><publisher>Japan: Blackwell Publishing Ltd</publisher><subject>Aged, 80 and over ; Case-Control Studies ; Chemotherapy ; Chemotherapy, Adjuvant ; Female ; Hospital Mortality ; Humans ; Male ; Medical prognosis ; Multivariate analysis ; Octogenarian ; Pancreatic cancer ; Pancreatic Neoplasms - mortality ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Postoperative Complications ; Postoperative prognosis ; Prognosis ; Retrospective Studies ; Risk Factors</subject><ispartof>Journal of hepato-biliary-pancreatic sciences, 2016-03, Vol.23 (3), p.188-197</ispartof><rights>2016 Japanese Society of Hepato‐Biliary‐Pancreatic Surgery</rights><rights>2016 Japanese Society of Hepato-Biliary-Pancreatic Surgery.</rights><rights>Copyright © 2016 Japanese Society of Hepato-Biliary-Pancreatic Surgery</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4260-ecae8778c90a475a7bcad5b957c89042fc6513756daeeb60cd89d9eb692848d83</citedby><cites>FETCH-LOGICAL-c4260-ecae8778c90a475a7bcad5b957c89042fc6513756daeeb60cd89d9eb692848d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjhbp.320$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjhbp.320$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26763744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sho, Masayuki</creatorcontrib><creatorcontrib>Murakami, Yoshiaki</creatorcontrib><creatorcontrib>Kawai, Manabu</creatorcontrib><creatorcontrib>Motoi, Fuyuhiko</creatorcontrib><creatorcontrib>Satoi, Sohei</creatorcontrib><creatorcontrib>Matsumoto, Ippei</creatorcontrib><creatorcontrib>Honda, Goro</creatorcontrib><creatorcontrib>Uemura, Kenichiro</creatorcontrib><creatorcontrib>Yanagimoto, Hiroaki</creatorcontrib><creatorcontrib>Kurata, Masanao</creatorcontrib><creatorcontrib>Akahori, Takahiro</creatorcontrib><creatorcontrib>Kinoshita, Shoichi</creatorcontrib><creatorcontrib>Nagai, Minako</creatorcontrib><creatorcontrib>Nishiwada, Satoshi</creatorcontrib><creatorcontrib>Fukumoto, Takumi</creatorcontrib><creatorcontrib>Unno, Michiaki</creatorcontrib><creatorcontrib>Yamaue, Hiroki</creatorcontrib><creatorcontrib>Nakajima, Yoshiyuki</creatorcontrib><title>Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study</title><title>Journal of hepato-biliary-pancreatic sciences</title><addtitle>J Hepatobiliary Pancreat Sci</addtitle><description>Background
The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. The aim of this study was to clarify the role of pancreatic resection in patients 80 years of age or older.
Methods
A retrospective multicenter analysis of 1401 patients who had undergone pancreatic resection for pancreatic cancer was performed. The patients aged ≥80 years (n = 99) were compared with a control group <80 years of age (n = 1302).
Results
There were no significant differences in the postoperative complications and mortality between the two groups. However, the prognosis of octogenarians was poorer than that of younger patients for both resectable and borderline resectable tumors. Importantly, there were few long‐term survivors in the elderly group, especially among those with borderline resectable pancreatic cancer. A multivariate analysis of the prognostic factors in the very elderly patients indicated that the completion of adjuvant chemotherapy was the only significant factor. In addition, preoperative albumin level was the only independent risk factor for a failure to complete adjuvant chemotherapy.
Conclusion
This study demonstrates that the postoperative prognosis in octogenarian patients was not good as that in younger patients possibly due to less frequent completion of adjuvant chemotherapy.
Highlight
Setting out to clarify the optimal therapeutic strategy for very elderly pancreatic cancer patients, Sho and colleagues demonstrated in this large multicenter study that the prognosis is poorer in octogenarians than in younger patients for both resectable and borderline resectable tumors, possibly due to less frequent completion of adjuvant chemotherapy.</description><subject>Aged, 80 and over</subject><subject>Case-Control Studies</subject><subject>Chemotherapy</subject><subject>Chemotherapy, Adjuvant</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Multivariate analysis</subject><subject>Octogenarian</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - mortality</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Postoperative Complications</subject><subject>Postoperative prognosis</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><issn>1868-6974</issn><issn>1868-6982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd1qFDEUx0NR2lILfQIJeOPN1Mwkkw_vdGm3lbUW_OhlyCRn1qzzsU1maPdtfJY-mRl3XUEwNzkcfufH4X8QOsvJeU5I8Wb1vVqf04IcoONccplxJYtn-1qwI3Qa44qkR3OqKDlERwUXnArGjtH9beiXXR99xKYeIOA4hqW3psFDADO00A247gNem85ODW-xTWUCfZeag09AGl2Cw5I8_dyACREnvm8chLfY4HZs0lCiJvcwus0L9Lw2TYTT3X-Cvl5efJldZYtP8-vZu0VmWcFJBtaAFEJaRQwTpRGVNa6sVCmsVIQVteVlTkXJnQGoOLFOKqdSpQrJpJP0BL3eetehvx8hDrr10ULTmA76MepcpGGaq4Ik9NU_6KofQ5e2mygmaEqR_RXa0McYoNbr4FsTNjonerqEni6h6W_hy51wrFpwe_BP7gnItsCDb2DzX5H-cPX-divc8T4O8LjnTfihuUgp6LubuZ5R_u3z_KPQC_oLQM-irw</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Sho, Masayuki</creator><creator>Murakami, Yoshiaki</creator><creator>Kawai, Manabu</creator><creator>Motoi, Fuyuhiko</creator><creator>Satoi, Sohei</creator><creator>Matsumoto, Ippei</creator><creator>Honda, Goro</creator><creator>Uemura, Kenichiro</creator><creator>Yanagimoto, Hiroaki</creator><creator>Kurata, Masanao</creator><creator>Akahori, Takahiro</creator><creator>Kinoshita, Shoichi</creator><creator>Nagai, Minako</creator><creator>Nishiwada, Satoshi</creator><creator>Fukumoto, Takumi</creator><creator>Unno, Michiaki</creator><creator>Yamaue, Hiroki</creator><creator>Nakajima, Yoshiyuki</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201603</creationdate><title>Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study</title><author>Sho, Masayuki ; Murakami, Yoshiaki ; Kawai, Manabu ; Motoi, Fuyuhiko ; Satoi, Sohei ; Matsumoto, Ippei ; Honda, Goro ; Uemura, Kenichiro ; Yanagimoto, Hiroaki ; Kurata, Masanao ; Akahori, Takahiro ; Kinoshita, Shoichi ; Nagai, Minako ; Nishiwada, Satoshi ; Fukumoto, Takumi ; Unno, Michiaki ; Yamaue, Hiroki ; Nakajima, Yoshiyuki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4260-ecae8778c90a475a7bcad5b957c89042fc6513756daeeb60cd89d9eb692848d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aged, 80 and over</topic><topic>Case-Control Studies</topic><topic>Chemotherapy</topic><topic>Chemotherapy, Adjuvant</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>Multivariate analysis</topic><topic>Octogenarian</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - mortality</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Postoperative Complications</topic><topic>Postoperative prognosis</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sho, Masayuki</creatorcontrib><creatorcontrib>Murakami, Yoshiaki</creatorcontrib><creatorcontrib>Kawai, Manabu</creatorcontrib><creatorcontrib>Motoi, Fuyuhiko</creatorcontrib><creatorcontrib>Satoi, Sohei</creatorcontrib><creatorcontrib>Matsumoto, Ippei</creatorcontrib><creatorcontrib>Honda, Goro</creatorcontrib><creatorcontrib>Uemura, Kenichiro</creatorcontrib><creatorcontrib>Yanagimoto, Hiroaki</creatorcontrib><creatorcontrib>Kurata, Masanao</creatorcontrib><creatorcontrib>Akahori, Takahiro</creatorcontrib><creatorcontrib>Kinoshita, Shoichi</creatorcontrib><creatorcontrib>Nagai, Minako</creatorcontrib><creatorcontrib>Nishiwada, Satoshi</creatorcontrib><creatorcontrib>Fukumoto, Takumi</creatorcontrib><creatorcontrib>Unno, Michiaki</creatorcontrib><creatorcontrib>Yamaue, Hiroki</creatorcontrib><creatorcontrib>Nakajima, Yoshiyuki</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sho, Masayuki</au><au>Murakami, Yoshiaki</au><au>Kawai, Manabu</au><au>Motoi, Fuyuhiko</au><au>Satoi, Sohei</au><au>Matsumoto, Ippei</au><au>Honda, Goro</au><au>Uemura, Kenichiro</au><au>Yanagimoto, Hiroaki</au><au>Kurata, Masanao</au><au>Akahori, Takahiro</au><au>Kinoshita, Shoichi</au><au>Nagai, Minako</au><au>Nishiwada, Satoshi</au><au>Fukumoto, Takumi</au><au>Unno, Michiaki</au><au>Yamaue, Hiroki</au><au>Nakajima, Yoshiyuki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study</atitle><jtitle>Journal of hepato-biliary-pancreatic sciences</jtitle><addtitle>J Hepatobiliary Pancreat Sci</addtitle><date>2016-03</date><risdate>2016</risdate><volume>23</volume><issue>3</issue><spage>188</spage><epage>197</epage><pages>188-197</pages><issn>1868-6974</issn><eissn>1868-6982</eissn><abstract>Background
The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. The aim of this study was to clarify the role of pancreatic resection in patients 80 years of age or older.
Methods
A retrospective multicenter analysis of 1401 patients who had undergone pancreatic resection for pancreatic cancer was performed. The patients aged ≥80 years (n = 99) were compared with a control group <80 years of age (n = 1302).
Results
There were no significant differences in the postoperative complications and mortality between the two groups. However, the prognosis of octogenarians was poorer than that of younger patients for both resectable and borderline resectable tumors. Importantly, there were few long‐term survivors in the elderly group, especially among those with borderline resectable pancreatic cancer. A multivariate analysis of the prognostic factors in the very elderly patients indicated that the completion of adjuvant chemotherapy was the only significant factor. In addition, preoperative albumin level was the only independent risk factor for a failure to complete adjuvant chemotherapy.
Conclusion
This study demonstrates that the postoperative prognosis in octogenarian patients was not good as that in younger patients possibly due to less frequent completion of adjuvant chemotherapy.
Highlight
Setting out to clarify the optimal therapeutic strategy for very elderly pancreatic cancer patients, Sho and colleagues demonstrated in this large multicenter study that the prognosis is poorer in octogenarians than in younger patients for both resectable and borderline resectable tumors, possibly due to less frequent completion of adjuvant chemotherapy.</abstract><cop>Japan</cop><pub>Blackwell Publishing Ltd</pub><pmid>26763744</pmid><doi>10.1002/jhbp.320</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged, 80 and over Case-Control Studies Chemotherapy Chemotherapy, Adjuvant Female Hospital Mortality Humans Male Medical prognosis Multivariate analysis Octogenarian Pancreatic cancer Pancreatic Neoplasms - mortality Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Postoperative Complications Postoperative prognosis Prognosis Retrospective Studies Risk Factors |
| title | Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study |
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