A systematic molecular dynamics approach to the study of peptide Keap1-Nrf2 protein-protein interaction inhibitors and its application to p62 peptides

Protein-protein interactions (PPIs) as drug targets have been gaining growing interest, though developing drug-like small molecule PPI inhibitors remains challenging. Peptide PPI inhibitors, which can provide informative data on the PPI interface, are good starting points to develop small molecule m...

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Veröffentlicht in:	Molecular bioSystems 2016-01, Vol.12 (4), p.1378-1387
Hauptverfasser:	Lu, Meng-Chen, Yuan, Zhen-Wei, Jiang, Yong-Lin, Chen, Zhi-Yun, You, Qi-Dong, Jiang, Zheng-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Binding Sites Dose-Response Relationship, Drug Drug Design Drug Discovery Hydrogen Bonding Hydrophobic and Hydrophilic Interactions Kelch-Like ECH-Associated Protein 1 - chemistry Kelch-Like ECH-Associated Protein 1 - metabolism Models, Molecular Molecular Conformation NF-E2-Related Factor 2 - chemistry NF-E2-Related Factor 2 - metabolism Peptides - chemistry Peptides - metabolism Peptides - pharmacology Phosphorylation Protein Binding - drug effects Quantitative Structure-Activity Relationship Signal Transduction - drug effects
Online-Zugang:	Volltext
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