Targeting nuclear transporters in cancer: Diagnostic, prognostic and therapeutic potential

The Karyopherin superfamily is a major class of soluble transport receptors consisting of both import and export proteins. The trafficking of proteins involved in transcription, cell signalling and cell cycle regulation among other functions across the nuclear membrane is essential for normal cellul...

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Veröffentlicht in:	IUBMB life 2016-04, Vol.68 (4), p.268-280
Hauptverfasser:	Stelma, Tamara, Chi, Alicia, van der Watt, Pauline J., Verrico, Annalisa, Lavia, Patrizia, Leaner, Virna D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - genetics Acetyltransferases - metabolism Active Transport, Cell Nucleus - drug effects Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism alpha Karyopherins - genetics alpha Karyopherins - metabolism Antineoplastic Agents - pharmacology Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism cancer CRM1/Exportin diagnostic/prognostic cancer biomarkers Exportin 1 Protein Gene Expression Regulation, Neoplastic Humans Karyopherin/Importin Karyopherins - genetics Karyopherins - metabolism Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - diagnosis Neoplasms - drug therapy Neoplasms - genetics Neoplasms - metabolism nuclear transport Prognosis Protein Transport - drug effects Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Signal Transduction Small Molecule Libraries - pharmacology therapeutic target Transcription Factors - genetics Transcription Factors - metabolism
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