Reaction Intermediates in the Catalytic Mechanism of Escherichia coli MutY DNA Glycosylase

The Escherichia coli adenine DNA glycosylase, MutY, plays an important role in the maintenance of genomic stability by catalyzing the removal of adenine opposite 8-oxo-7,8-dihydroguanine or guanine in duplex DNA. Although the x-ray crystal structure of the catalytic domain of MutY revealed a mechani...

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Veröffentlicht in:	The Journal of biological chemistry 2004-11, Vol.279 (45), p.46930-46939
Hauptverfasser:	Manuel, Raymond C, Hitomi, Kenichi, Arvai, Andrew S, House, Paul G, Kurtz, Andrew J, Dodson, M L, McCullough, Amanda K, Tainer, John A, Lloyd, R Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - chemistry Aspartic Acid - chemistry Binding Sites Catalysis Catalytic Domain Crystallography, X-Ray DNA - chemistry DNA Glycosylases - chemistry DNA Glycosylases - metabolism Dose-Response Relationship, Drug Escherichia coli Escherichia coli - enzymology Glutamic Acid - chemistry Guanine - chemistry Kinetics Lysine - chemistry Models, Chemical Models, Molecular Mutagenesis, Site-Directed Mutation Protein Conformation Time Factors
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