Oral Anticoagulation After Successful Atrial Fibrillation Ablation Operations: Is It Necessary?

Background This study analyzed the results of atrial fibrillation (AF) ablation concomitant to open heart operations using continuous monitoring. Methods We investigated 70 consecutive patients (mean age, 72.1 ± 6 years; European System for Cardiac Operative Risk Evaluation II: 9.7% ± 8.2%) who unde...

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Veröffentlicht in:The Annals of thoracic surgery 2016-04, Vol.101 (4), p.1471-1476
Hauptverfasser: Schlingloff, Friederike, MD, Oberhoffer, Martin, MD, Quasdorff, Ines, Wohlmuth, Peter, Schmoeckel, Michael, MD, Geidel, Stephan, MD
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container_end_page 1476
container_issue 4
container_start_page 1471
container_title The Annals of thoracic surgery
container_volume 101
creator Schlingloff, Friederike, MD
Oberhoffer, Martin, MD
Quasdorff, Ines
Wohlmuth, Peter
Schmoeckel, Michael, MD
Geidel, Stephan, MD
description Background This study analyzed the results of atrial fibrillation (AF) ablation concomitant to open heart operations using continuous monitoring. Methods We investigated 70 consecutive patients (mean age, 72.1 ± 6 years; European System for Cardiac Operative Risk Evaluation II: 9.7% ± 8.2%) who underwent AF ablation concomitant to cardiac operations in our institution between February 2012 and February 2013. For precise rhythm analysis we implanted Reveal XT devices (Medtronic Inc, Minneapolis, MN) in all patients at the end of operations. Twenty-two patients had paroxysmal (31.4%), 20 persistent (28.6%) and 28 longstanding-persistent AF (40%). AF duration time was at a median 18 months. Cardiac rhythm data were obtained by telemonitoring at 1-month intervals, and the AF burden was calculated at 3, 6, and 9 months and at 1 year postoperatively (ablation procedure success was defined as a burden of ≤0.5%). Further, a neurologic follow-up was performed at 1 year postoperatively. Results Overall survival was 95.7% at 30 days and 84.3% at 1 year. At 1 year, 66.7% of patients were in stable sinus rhythm, and AF burden was significantly reduced even in nonresponders: 88.2% of patients were off antiarrhythmic drugs, and oral anticoagulation had been stopped in 92.1%. No late neurologic events had occurred. Sinus rhythm at discharge and paroxysmal type of AF were predictive for later sinus rhythm ( p  = 0.04 and p  = 0.048, respectively). Conclusions Considering the long AF duration and the high proportion of longstanding-persistent AF, the overall success of ablation procedures was satisfactory. Even though oral anticoagulation was stopped in most patients, no neurologic events were detected.
doi_str_mv 10.1016/j.athoracsur.2015.10.008
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Methods We investigated 70 consecutive patients (mean age, 72.1 ± 6 years; European System for Cardiac Operative Risk Evaluation II: 9.7% ± 8.2%) who underwent AF ablation concomitant to cardiac operations in our institution between February 2012 and February 2013. For precise rhythm analysis we implanted Reveal XT devices (Medtronic Inc, Minneapolis, MN) in all patients at the end of operations. Twenty-two patients had paroxysmal (31.4%), 20 persistent (28.6%) and 28 longstanding-persistent AF (40%). AF duration time was at a median 18 months. Cardiac rhythm data were obtained by telemonitoring at 1-month intervals, and the AF burden was calculated at 3, 6, and 9 months and at 1 year postoperatively (ablation procedure success was defined as a burden of ≤0.5%). Further, a neurologic follow-up was performed at 1 year postoperatively. Results Overall survival was 95.7% at 30 days and 84.3% at 1 year. At 1 year, 66.7% of patients were in stable sinus rhythm, and AF burden was significantly reduced even in nonresponders: 88.2% of patients were off antiarrhythmic drugs, and oral anticoagulation had been stopped in 92.1%. No late neurologic events had occurred. Sinus rhythm at discharge and paroxysmal type of AF were predictive for later sinus rhythm ( p  = 0.04 and p  = 0.048, respectively). Conclusions Considering the long AF duration and the high proportion of longstanding-persistent AF, the overall success of ablation procedures was satisfactory. Even though oral anticoagulation was stopped in most patients, no neurologic events were detected.</description><identifier>ISSN: 0003-4975</identifier><identifier>EISSN: 1552-6259</identifier><identifier>DOI: 10.1016/j.athoracsur.2015.10.008</identifier><identifier>PMID: 26627178</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Administration, Oral ; Aged ; Aged, 80 and over ; Anticoagulants - administration &amp; dosage ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - mortality ; Atrial Fibrillation - surgery ; Cardiac Surgical Procedures - adverse effects ; Cardiac Surgical Procedures - methods ; Cardiothoracic Surgery ; Catheter Ablation - methods ; Catheter Ablation - mortality ; Cohort Studies ; Combined Modality Therapy ; Electrocardiography ; Female ; Follow-Up Studies ; Germany ; Hospital Mortality - trends ; Humans ; Logistic Models ; Male ; Middle Aged ; Monitoring, Physiologic - methods ; Patient Safety - statistics &amp; numerical data ; Postoperative Care - methods ; Retrospective Studies ; Risk Assessment ; Severity of Illness Index ; Statistics, Nonparametric ; Surgery ; Survival Rate ; Time Factors ; Treatment Outcome</subject><ispartof>The Annals of thoracic surgery, 2016-04, Vol.101 (4), p.1471-1476</ispartof><rights>The Society of Thoracic Surgeons</rights><rights>2016 The Society of Thoracic Surgeons</rights><rights>Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-55106e5c0a9e5813d8cc9eae529f0615e5d39c5e7e3d50e5d006db1f7723e51c3</citedby><cites>FETCH-LOGICAL-c549t-55106e5c0a9e5813d8cc9eae529f0615e5d39c5e7e3d50e5d006db1f7723e51c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.athoracsur.2015.10.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26627178$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schlingloff, Friederike, MD</creatorcontrib><creatorcontrib>Oberhoffer, Martin, MD</creatorcontrib><creatorcontrib>Quasdorff, Ines</creatorcontrib><creatorcontrib>Wohlmuth, Peter</creatorcontrib><creatorcontrib>Schmoeckel, Michael, MD</creatorcontrib><creatorcontrib>Geidel, Stephan, MD</creatorcontrib><title>Oral Anticoagulation After Successful Atrial Fibrillation Ablation Operations: Is It Necessary?</title><title>The Annals of thoracic surgery</title><addtitle>Ann Thorac Surg</addtitle><description>Background This study analyzed the results of atrial fibrillation (AF) ablation concomitant to open heart operations using continuous monitoring. Methods We investigated 70 consecutive patients (mean age, 72.1 ± 6 years; European System for Cardiac Operative Risk Evaluation II: 9.7% ± 8.2%) who underwent AF ablation concomitant to cardiac operations in our institution between February 2012 and February 2013. For precise rhythm analysis we implanted Reveal XT devices (Medtronic Inc, Minneapolis, MN) in all patients at the end of operations. Twenty-two patients had paroxysmal (31.4%), 20 persistent (28.6%) and 28 longstanding-persistent AF (40%). AF duration time was at a median 18 months. Cardiac rhythm data were obtained by telemonitoring at 1-month intervals, and the AF burden was calculated at 3, 6, and 9 months and at 1 year postoperatively (ablation procedure success was defined as a burden of ≤0.5%). Further, a neurologic follow-up was performed at 1 year postoperatively. Results Overall survival was 95.7% at 30 days and 84.3% at 1 year. At 1 year, 66.7% of patients were in stable sinus rhythm, and AF burden was significantly reduced even in nonresponders: 88.2% of patients were off antiarrhythmic drugs, and oral anticoagulation had been stopped in 92.1%. No late neurologic events had occurred. Sinus rhythm at discharge and paroxysmal type of AF were predictive for later sinus rhythm ( p  = 0.04 and p  = 0.048, respectively). Conclusions Considering the long AF duration and the high proportion of longstanding-persistent AF, the overall success of ablation procedures was satisfactory. Even though oral anticoagulation was stopped in most patients, no neurologic events were detected.</description><subject>Administration, Oral</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anticoagulants - administration &amp; dosage</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - mortality</subject><subject>Atrial Fibrillation - surgery</subject><subject>Cardiac Surgical Procedures - adverse effects</subject><subject>Cardiac Surgical Procedures - methods</subject><subject>Cardiothoracic Surgery</subject><subject>Catheter Ablation - methods</subject><subject>Catheter Ablation - mortality</subject><subject>Cohort Studies</subject><subject>Combined Modality Therapy</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Germany</subject><subject>Hospital Mortality - trends</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic - methods</subject><subject>Patient Safety - statistics &amp; numerical data</subject><subject>Postoperative Care - methods</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Surgery</subject><subject>Survival Rate</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0003-4975</issn><issn>1552-6259</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUtPGzEQx62qCMLjK1R77GUXP5h99NAqRAQiIXIAzpYzO9s63eymtheJb4-XhCJx4uR5_Obh_zCWCJ4JLvLzdWbCn94Z9IPLJBcQwxnn5Rc2EQAyzSVUX9mEc67Si6qAI3bs_Tq6MqYP2ZHMc1mIopwwvXSmTaZdsNib30Nrgu27ZNoEcsn9gEjeN0MEgrORm9uVs-0btNobyy25V8v_SBY-WYTkjsZC455_nbKDxrSezvbvCXucXz3MbtLb5fViNr1NES6qkAIInhMgNxVBKVRdIlZkCGTV8FwAQa0qBCpI1cCjx3ler0RTFFIRCFQn7Puu79b1_wbyQW-sR4q7dtQPXouiAFWqKFVEyx2KrvfeUaO3zm7islpwPcqr1_pdXj3KO2aivLH0237KsNpQ_b_wTc8IXO4Ain99suS0R0sdUm0dYdB1bz8z5eeHJtjazqJp_9Iz-XU_uC5qqYX2UnN9P555vLKA2DYvK_UCEIumbA</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Schlingloff, Friederike, MD</creator><creator>Oberhoffer, Martin, MD</creator><creator>Quasdorff, Ines</creator><creator>Wohlmuth, Peter</creator><creator>Schmoeckel, Michael, MD</creator><creator>Geidel, Stephan, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20160401</creationdate><title>Oral Anticoagulation After Successful Atrial Fibrillation Ablation Operations: Is It Necessary?</title><author>Schlingloff, Friederike, MD ; Oberhoffer, Martin, MD ; Quasdorff, Ines ; Wohlmuth, Peter ; Schmoeckel, Michael, MD ; Geidel, Stephan, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-55106e5c0a9e5813d8cc9eae529f0615e5d39c5e7e3d50e5d006db1f7723e51c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Administration, Oral</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anticoagulants - administration &amp; dosage</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - mortality</topic><topic>Atrial Fibrillation - surgery</topic><topic>Cardiac Surgical Procedures - adverse effects</topic><topic>Cardiac Surgical Procedures - methods</topic><topic>Cardiothoracic Surgery</topic><topic>Catheter Ablation - methods</topic><topic>Catheter Ablation - mortality</topic><topic>Cohort Studies</topic><topic>Combined Modality Therapy</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Germany</topic><topic>Hospital Mortality - trends</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monitoring, Physiologic - methods</topic><topic>Patient Safety - statistics &amp; numerical data</topic><topic>Postoperative Care - methods</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Surgery</topic><topic>Survival Rate</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schlingloff, Friederike, MD</creatorcontrib><creatorcontrib>Oberhoffer, Martin, MD</creatorcontrib><creatorcontrib>Quasdorff, Ines</creatorcontrib><creatorcontrib>Wohlmuth, Peter</creatorcontrib><creatorcontrib>Schmoeckel, Michael, MD</creatorcontrib><creatorcontrib>Geidel, Stephan, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Annals of thoracic surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schlingloff, Friederike, MD</au><au>Oberhoffer, Martin, MD</au><au>Quasdorff, Ines</au><au>Wohlmuth, Peter</au><au>Schmoeckel, Michael, MD</au><au>Geidel, Stephan, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Oral Anticoagulation After Successful Atrial Fibrillation Ablation Operations: Is It Necessary?</atitle><jtitle>The Annals of thoracic surgery</jtitle><addtitle>Ann Thorac Surg</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>101</volume><issue>4</issue><spage>1471</spage><epage>1476</epage><pages>1471-1476</pages><issn>0003-4975</issn><eissn>1552-6259</eissn><abstract>Background This study analyzed the results of atrial fibrillation (AF) ablation concomitant to open heart operations using continuous monitoring. Methods We investigated 70 consecutive patients (mean age, 72.1 ± 6 years; European System for Cardiac Operative Risk Evaluation II: 9.7% ± 8.2%) who underwent AF ablation concomitant to cardiac operations in our institution between February 2012 and February 2013. For precise rhythm analysis we implanted Reveal XT devices (Medtronic Inc, Minneapolis, MN) in all patients at the end of operations. Twenty-two patients had paroxysmal (31.4%), 20 persistent (28.6%) and 28 longstanding-persistent AF (40%). AF duration time was at a median 18 months. Cardiac rhythm data were obtained by telemonitoring at 1-month intervals, and the AF burden was calculated at 3, 6, and 9 months and at 1 year postoperatively (ablation procedure success was defined as a burden of ≤0.5%). Further, a neurologic follow-up was performed at 1 year postoperatively. Results Overall survival was 95.7% at 30 days and 84.3% at 1 year. At 1 year, 66.7% of patients were in stable sinus rhythm, and AF burden was significantly reduced even in nonresponders: 88.2% of patients were off antiarrhythmic drugs, and oral anticoagulation had been stopped in 92.1%. No late neurologic events had occurred. Sinus rhythm at discharge and paroxysmal type of AF were predictive for later sinus rhythm ( p  = 0.04 and p  = 0.048, respectively). Conclusions Considering the long AF duration and the high proportion of longstanding-persistent AF, the overall success of ablation procedures was satisfactory. Even though oral anticoagulation was stopped in most patients, no neurologic events were detected.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>26627178</pmid><doi>10.1016/j.athoracsur.2015.10.008</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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subjects Administration, Oral
Aged
Aged, 80 and over
Anticoagulants - administration & dosage
Atrial Fibrillation - diagnosis
Atrial Fibrillation - mortality
Atrial Fibrillation - surgery
Cardiac Surgical Procedures - adverse effects
Cardiac Surgical Procedures - methods
Cardiothoracic Surgery
Catheter Ablation - methods
Catheter Ablation - mortality
Cohort Studies
Combined Modality Therapy
Electrocardiography
Female
Follow-Up Studies
Germany
Hospital Mortality - trends
Humans
Logistic Models
Male
Middle Aged
Monitoring, Physiologic - methods
Patient Safety - statistics & numerical data
Postoperative Care - methods
Retrospective Studies
Risk Assessment
Severity of Illness Index
Statistics, Nonparametric
Surgery
Survival Rate
Time Factors
Treatment Outcome
title Oral Anticoagulation After Successful Atrial Fibrillation Ablation Operations: Is It Necessary?
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